Kellen Voss, Christopher Harris, Martina Ralle, Megan Duffy, Charles Murchison, Joseph F Quinn
The transition metal copper enhances amyloid β aggregation and neurotoxicity, and in models of concomitant amyloid and tau pathology, copper also promotes tau aggregation. Since it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloid β, we tested the effects of copper overload and complexing in disease models which lack pathol...... hiện toàn bộ