Translational Neurodegeneration

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders
Translational Neurodegeneration - Tập 5 - Trang 1-8 - 2016
Zhibin Wang, Xiao-Guang Luo, Chao Gao
In the clinic, the diagnosis of Parkinson’s disease (PD) largely depends on clinicians’ experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian disorders (APD). Clinially-available 3T conventional MRI contributes little to solve these problems. ...... hiện toàn bộ
Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
Translational Neurodegeneration - - 2024
Wen Li, Jia-Yi Li
Proteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented by Alzheimer’s disease (AD), and synucleinopathies, represented by Parkinson’s disease (PD), show similarities in multiple aspects. AD manifests extrapyramidal symptoms while dementia is als...... hiện toàn bộ
The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease
Translational Neurodegeneration - Tập 8 - Trang 1-11 - 2019
Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, Eunice Eun Seo Chang, David Boyer Ramsden, Shu-Leong Ho
Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-synuclein, the major constituent of LB, spreads to different regions of the brain in a prion-like fashion, giving rise to successive non-motor and motor symptoms. Etiology is likely multifactori...... hiện toàn bộ
Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
Translational Neurodegeneration - Tập 8 Số 1 - 2019
Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Ren‐Hong Du, Ming Xiao, Gang Hu
Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts
Translational Neurodegeneration - - 2020
Xiaohuan Xia, Chunhong Li, Yi Wang, Xiaobei Deng, Yizhao Ma, Lu Ding, Jialin Zheng
AbstractThe direct reprogramming of somatic cells into induced neural progenitor cells (iNPCs) has been envisioned as a promising approach to overcome ethical and clinical issues of pluripotent stem cell transplantation. We previously reported that astrocyte-derived induced pluripotent stem cells (iPSCs) have more tendencies for neuronal differentiation than fibrob...... hiện toàn bộ
Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease
Translational Neurodegeneration - Tập 10 - Trang 1-11 - 2021
Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Yiong Huak Chan, Lai Jiang, Joseph Therriault, Andrea L. Benedet, Monica Shin, Nagaendran Kandiah, Celia M. T. Greenwood, Pedro Rosa-Neto, Serge Gauthier
Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer’s disease (AD) continuum. However, the role of NPS as an early marker of pathophysiological progression in AD remains unclear. Dominantly inherited AD (DIAD) mutation carriers are young individuals who are destined to develop AD in future due to the full penetrance of the genetic muta...... hiện toàn bộ
Rest tremor revisited: Parkinson’s disease and other disorders
Translational Neurodegeneration - Tập 6 - Trang 1-8 - 2017
Wei Chen, Franziska Hopfner, Jos Steffen Becktepe, Günther Deuschl
Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is challenging to make an accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalen...... hiện toàn bộ
Disease modification and Neuroprotection in neurodegenerative disorders
Translational Neurodegeneration - Tập 6 - Trang 1-7 - 2017
Jeffrey Cummings
Disease modifying therapies (DMTs) are urgently needed for neurodegenerative diseases (NDD) such as Alzheimer’s disease (AD) and many other disorders characterized by protein aggregation and neurodegeneration. Despite advances in understanding the neurobiology of NDD, there are no approved DMTs. Defining disease-modification is critical to drug-development programs. A DMT is an intervention that p...... hiện toàn bộ
Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort
Translational Neurodegeneration - - 2018
Bin Jiao, Qiying Sun, Zhenhua Yuan, Junling Wang, Lin Zhou, Xin-xiang Yan, Beisha Tang, Lu Shen
Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
Translational Neurodegeneration - Tập 12 - Trang 1-16 - 2023
Xavier Sánchez-Sáez, Isabel Ortuño-Lizarán, Carla Sánchez-Castillo, Pedro Lax, Nicolás Cuenca
The main clinical symptoms characteristic of Parkinson’s disease (PD) are bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as visual disturbances, can be identified at early stages of the disease. One of these symptoms is the impairment of visual motion perception. Hence, we sought to determine if the starburst amacrine cells, which are the main cellular type invol...... hiện toàn bộ
Tổng số: 311   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10