Translational Neurodegeneration
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Nanotechnology for microglial targeting and inhibition of neuroinflammation underlying Alzheimer’s pathology
Translational Neurodegeneration - Tập 13 - Trang 1-24 - 2024
Alzheimer's disease (AD) is considered to have a multifactorial etiology. The hallmark of AD is progressive neurodegeneration, which is characterized by the deepening loss of memory and a high mortality rate in the elderly. The neurodegeneration in AD is believed to be exacerbated following the intercoupled cascades of extracellular amyloid beta (Aβ) plaques, uncontrolled microglial activation, an...... hiện toàn bộ
Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis
Translational Neurodegeneration - Tập 4 - Trang 1-8 - 2015
Nonmotor symptoms are common among patients with Parkinson’s disease (PD) and some may precede disease diagnosis. We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis, using random-effect models. We searched PubMed (1965 through October/November 2012) for the following symptoms: hyposmia, constipation, rapid eye movement sleep behavior disorder...... hiện toàn bộ
Annual acknowledgement of manuscript reviewers
Translational Neurodegeneration - Tập 3 - Trang 1-2 - 2014
The editors of Translational Neurodegeneration would like to thank all our reviewers who have contributed to the journal in Volume 2 (2013).
The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer’s disease
Translational Neurodegeneration - - 2017
Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases
Translational Neurodegeneration - Tập 9 - Trang 1-16 - 2020
Mitochondria are the energy center of cell operations and are involved in physiological functions and maintenance of metabolic balance and homeostasis in the body. Alterations of mitochondrial function are associated with a variety of degenerative and acute diseases. As mitochondria age in cells, they gradually become inefficient and potentially toxic. Acute injury can trigger the permeability of ...... hiện toàn bộ
Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
Translational Neurodegeneration - Tập 10 - Trang 1-15 - 2021
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the ep...... hiện toàn bộ
The underlying mechanism of prodromal PD: insights from the parasympathetic nervous system and the olfactory system
Translational Neurodegeneration - Tập 6 - Trang 1-9 - 2017
Neurodegeneration of Parkinson’s disease (PD) starts in an insidious manner, 30–50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, during which the disease pathology has started but is insufficient to result in clinical manifestations, offers a valuable window for disease-modifying therapies. The most focused underlying mec...... hiện toàn bộ
Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder
Translational Neurodegeneration - Tập 6 Số 1 - 2017
Multivariable clinical-genetic model for predicting dyskinesia in early-onset Parkinson’s disease
Translational Neurodegeneration - Tập 10 - Trang 1-3 - 2021
Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
Translational Neurodegeneration - Tập 8 Số 1 - 2019
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