Translational Neurodegeneration
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Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders
Translational Neurodegeneration - Tập 5 - Trang 1-8 - 2016
In the clinic, the diagnosis of Parkinson’s disease (PD) largely depends on clinicians’ experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian disorders (APD). Clinially-available 3T conventional MRI contributes little to solve these problems. ......
Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
Translational Neurodegeneration - - 2015
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is characterized by neuronal loss and degeneration of the upper motor neurons (UMNs) and lower motor neurons (LMNs), and is usually fatal due to respiratory failure within 3–5 years of onset. Although approximately 5–10 % of patients with ALS have an inherited form of the disease, the distinction between he......
A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Translational Neurodegeneration - Tập 12 - Trang 1-4 - 2023
ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered,
https://classic.clinicaltrials.gov/ct2/show/NCT05821153
Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
Translational Neurodegeneration - - 2024
Proteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented by Alzheimer’s disease (AD), and synucleinopathies, represented by Parkinson’s disease (PD), show similarities in multiple aspects. AD manifests extrapyramidal symptoms while dementia is als......
Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system
Translational Neurodegeneration - Tập 1 - Trang 1-7 - 2012
Amyloid beta peptide (Aβ) is the main component of extraneuronal senile plaques typical of Alzheimer’s disease (AD) brains. Although Aβ is produced by normal neurons, it is shown to accumulate in large amounts within neuronal lysosomes in AD. We have recently shown that under normal conditions the majority of Aβ is localized extralysosomally, while oxidative stress significantly increases intralys......
Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
Translational Neurodegeneration - Tập 8 - Trang 1-14 - 2019
Parkinson’s disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms. PD is characterized by intraneuronal accumulation of abnormal α-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of either α-synuclein, as in the case of Multiple System Atrophy (MSA) or ta......
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Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease
Translational Neurodegeneration - Tập 10 - Trang 1-9 - 2021
As the most common form of dementia, Alzheimer’s disease (AD) is characterized by progressive cognitive impairments and constitutes a major social burden. Currently, the invasiveness and high costs of tests have limited the early detection and intervention of the disease. As a unique window of the brain, retinal changes can reflect the pathology of the brain. In this review, we summarize current u......
Anatomical correlates of blepharospasm
Translational Neurodegeneration - Tập 1 - Trang 1-7 - 2012
Focal dystonia is a neurological disorder characterized by unwanted muscle spasms. Blepharospasm is a focal dystonia producing an involuntary closure of the eyelid. Its etiology is unknown. To investigate if there are structural changes in the white and grey matter of blepharospasm patients, and if the changes are related to disease features. T1 and diffusion-weighted magnetic resonance imaging sc......
The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease
Translational Neurodegeneration - Tập 8 - Trang 1-11 - 2019
Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-synuclein, the major constituent of LB, spreads to different regions of the brain in a prion-like fashion, giving rise to successive non-motor and motor symptoms. Etiology is likely multifactori......
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease
Translational Neurodegeneration - Tập 11 - Trang 1-12 - 2022
Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progression of these diseases. Particularly, hypomethylation of the amyloid precursor protein gene (APP) has been reported in patients with AD. In this study, we used catalytically inactivated Cas9 (......
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