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Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity
Cancer Letters - Tập 220 - Trang 137-144 - 2005
Jacqui Adams, Darren Cuthbert-Heavens, Sylvia Bass, Margaret A. Knowles
Implication of the Long Non-Coding RNA Crnde in Multiple Myeloma
Blood - Tập 130 - Trang 4357 - 2017
Antoine David, Ashley Ohnona, Alexis Talbot, Wendy Cuccuini, Jean-Paul Fermand, Jean Soulier, Bertrand Arnulf, Jean Christophe Bories, Michele Goodhardt, David Garrick
Potentially preventable trauma deaths: A retrospective review
Injury - Tập 50 - Trang 1009-1016 - 2019
Ben Beck, Karen Smith, Eric Mercier, Stephen Bernard, Colin Jones, Ben Meadley, Toby St Clair, Paul A. Jennings, Ziad Nehme, Michael Burke, Richard Bassed, Mark Fitzgerald, Rodney Judson, Warwick Teague, Biswadev Mitra, Joseph Mathew, Andrew Buck, Dinesh Varma, Belinda Gabbe, Janet Bray
Notes on anaesthetizing crabs
Hydrobiologia - Tập 38 - Trang 335-337 - 1971
N. G. Kurup
Electrochemistry of Tin in Borate Buffer Solutions: An in-situ Raman study.
Springer Science and Business Media LLC - Tập 781 - Trang 131-136 - 2004
Raül Díaz, Ismael Díez-Pérez, Pau Grostiza, Fausto Sanz, Susanne Joiret, Philippe Allongue
The electrochemical behavior of chemically polished polycrystalline tin is investigated in borate buffer solutions at pH=7.5 using in-situ Raman measurements. Experiments reveal the appearance of “luminescence” under continuum red laser light only for a narrow range of sample potentials within the anodic plateau. The phenomenon is discussed in view of the tin oxides formed on the surface, and correlated with the assignation of the oxido-reduction processes observed in the voltammograms.
Molecular identification of sulfadoxine-pyrimethamine resistance in malaria infected women who received intermittent preventive treatment in the Democratic Republic of Congo
Malaria Journal - Tập 17 - Trang 1-7 - 2018
Emrah Ruh, Jean Paul Bateko, Turgut Imir, Aysegul Taylan-Ozkan
Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes which confer resistance to sulfadoxine-pyrimethamine (SP) occur at increasing rates. The present study aimed to identify Pfdhfr and Pfdhps mutations in P. falciparum isolates recovered from women who received two doses of SP during pregnancy in Bandundu, the Democratic Republic of Congo (DRC). A total of 48 women with confirmed P. falciparum infection were enrolled in the study. Finger-prick blood samples that were collected on filter paper at the time of delivery were used for DNA isolation. Pfdhfr and Pfdhps genes were amplified by a nested PCR protocol. DNA sequencing was performed on both strands, and the point mutations were analysed. All of the 48 (100.0%) P. falciparum isolates carried at least one polymorphism in both genes. The wild-type haplotypes of Pfdhfr (CNCSI [C50, N51, C59, S108, I164]) and Pfdhps (SAKAA [S436, A437, K540, A581, A613]) were not observed in the study. In Pfdhfr, N51I (85.4%), C59R (60.4%), and S108N (100.0%) polymorphisms were detected. Triple mutation (CIRNI) (mutant amino acids are underlined) was the most prevalent (47.9%) Pfdhfr haplotype. In the study, all P. falciparum isolates (100.0%) harboured the A437G allele in Pfdhps gene. Also, K540E and A581G polymorphisms were observed in one (2.1%) isolate. Single mutant haplotype (SGKAA) was detected in 97.9% of the isolates. Mutant Pfdhfr and Pfdhps allele combinations revealed quintuple (CICNI-SGEGA; 2.1%), quadruple (CIRNI-SGKAA; 47.9%), triple (CICNI-SGKAA; 35.4%, CNRNI-SGKAA; 12.5%), and double (CNCNI-SGKAA; 2.1%) haplotypes. In the study, the rate of SGEGA haplotype was low (2.1%). Although K540E and A581G alleles are more common in Eastern Africa, a distinct lineage of SGEGA is also present in the DRC, which is located in Central Africa. This haplotype is associated with decreased efficacy of SP in pregnant women and infants, therefore, it should be carefully considered in the DRC and SP resistance should be routinely monitored.
Results of arthrodesis and operative stabilization of osteotomies with a compression staple system
The Foot - Tập 13 - Trang 100-107 - 2003
G Schwetlick, R Kreusch-Brinker, H Mellerowicz, G Nießen, M Rauschmann
Effects of diuretics on iodine uptake in non-toxic goitre: comparison with low-iodine diet
European Journal of Nuclear Medicine - Tập 30 - Trang 1270-1272 - 2003
L. Ozlem Kapucu, Fırat Azizoglu, Goksun Ayvaz, Ayhan Karakoc
Low-iodine diet has been employed to achieve iodine depletion prior to radioiodine (RI) therapy. However, treatment with diuretics may be more effective than low-iodine diet in causing iodine depletion and subsequent increase in RI uptake by the thyroid. Fifty-five patients with non-toxic goitre were given 0.20 MBq RI p.o. on the first day of the study and thyroid uptake was measured. In 15 patients, a low-iodine diet was started and continued for 14 days. The remaining 40 patients received furosemide 40 mg/day orally for 5 days with an unrestricted diet. On the 15th day of the study, all patients were given 0.20 MBq RI p.o. and thyroid RI uptake was measured again. Additionally, 24-h urinary iodine excretion and RI clearance were measured on the 1st and 6th days in 21 patients from the furosemide group and on the 1st and 15th days in eight patients from the diet group. Furosemide administration led to a 58.40% increase in iodine uptake over the baseline value, which was significantly higher than the increase caused by low-iodine diet (17.22%) (P<0.0001). Urinary excretion of RI decreased in both groups similarly (furosemide, 29.45%; low-iodine diet, 21.06%; P=0.33). Iodine clearance also decreased in each group similarly (10.61% vs 7.53%, P=0.53). Treatment with furosemide prior to administration of RI increases the uptake of RI by the thyroid more effectively than does low-iodine diet.
Diagnosis of Enteric Disease in Small Ruminants
Veterinary Clinics of North America: Food Animal Practice - Tập 16 - Trang 87-115 - 2000
David C. Van Metre
EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma
Cancer Cell International - Tập 21 - Trang 1-17 - 2021
Mingming Deng, Run Tong, Zhe Zhang, Tao Wang, Chaonan Liang, Xiaoming Zhou, Gang Hou
Ephrin receptors (Eph) and their ligands, called ephrins, function in various disease processes. However, the expression level and prognostic value of Eph/ephrins in lung adenocarcinoma (LUAD) are still unclear. The Oncomine and GEPIA databases were used to explore the differential expression of Eph/ephrins in LUAD. Kaplan–Meier plotter was selected to explore the prognostic value of Eph/ephrins. The cBioPortal database was used to analyze the genetic variation of the EFNA3 gene. Immunohistochemistry was used to analyze the expression level and clinical value of ephrin-A3 protein in clinical LUAD tissue. Weighted coexpression network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified the potential regulatory mechanism of EFNA3. CCK-8 assays and colony-forming experiments were used to investigate whether EFNA3 can regulate cell proliferation ability in LUAD. Analysis of lactate, ATP, and glucose uptake levels was used to explore the effect of EFNA3 on glycolysis ability. In addition, we investigated the relationship between EFNA3 and tumor infiltrating immune cells (TIICs). Finally, the potential immunotherapy response prediction value of EFNA3 was also explored. In this study, we found that EFNA3 expression was significantly correlated with both overall survival (OS) and progression-free survival (PFS) in LUAD patients based on a comprehensive analysis of the Eph/Ephrin family. Next, the expression of the EFNA3 protein was increased in LUAD tissues and was designated an independent prognostic risk factor. Mechanistically, EFNA3 may be involved in nuclear division, synaptic function, and ion channel activity-related pathways. In vitro experiments confirmed the role of EFNA3 in promoting LUAD cells and showed that it could regulate glycolytic capacity. Moreover, EFNA3 was negatively associated with immunity, stromal infiltration, and several TIICs. Finally, EFNA3 was found to be positively related to multiple immunotherapy biomarkers. In conclusion, increased EFNA3 in LUAD patients predicted worse clinical prognosis, promoted LUAD cell proliferation and glycolysis ability, and was related to immunotherapy response.
Tổng số: 14,487,570   
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