Translational Medicine Communications
2396-832X
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Các bài báo tiêu biểu
Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles
Tập 4 Số 1 - 2019
AbstractA rift that has opened up between basic research (bench) and clinical
research and patients (bed) who need their new treatments, diagnostics and
prevention, and this rift is widening and getting deeper. The crisis involving
the “translation” of basic scientific findings in a laboratory setting into
human applications and potential treatments or biomarkers for a disease is
widely recognized...
Adoption of telehealth technologies: an approach to improving healthcare system
Tập 7 - Trang 1-8 - 2022
Globally, the healthcare industry is well known to be one of the strongest
drivers of economic growth and development. The sector has gained substantial
attention to deal with the fallout of COVID-19, leading to improvement in the
quality observed in developed and developing nations. With the advent of the
twenty-first century, globalization an ever-growing populace, and environmental
changes prom...
The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic review
- 2021
AbstractSerotonin or 5-hydroxytryptamine (5-HT)- a neurotransmitter of both the
Enteric Nervous System and the Central Nervous System is synthesized by the
hydroxylation of L- tryptophan to 5-hydroxytryptophan.Serotonin has been
associated with gut functions like assimilation and absorption, alongside the
regulation of particle transport and fluid discharge in the gastrointestinal
tract and its de...
Comparative molecular cell-of-origin classification of diffuse large B-cell lymphoma based on liquid and tissue biopsies
- 2020
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is a heterogenous
blood cancer, but can be broadly classified into two main subtypes, germinal
center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtypes
have very different clinical courses, with ABC having a much worse survival
prognosis. It has been observed that patients with different subtypes also
respond different...
Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study
- 2020
Abstract Background Intense exercise is a systemic stressor associated with the
release of “danger” molecules – alarmins, by damaged or dying cells into
systemic circulation to evoke a sterile inflammatory response. Compared with
research in clinical diseases, physiological responses of alarmins to exercise
and training are not well studied. Short-term responses to exercise and training
using a pa...
Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches
- 2020
Abstract Background Infectious bronchitis (IB) is a highly contagious
respiratory disease in chickens and produces economic loss within the poultry
industry. This disease is caused by a single stranded RNA virus belonging to
Cronaviridae family. This study aimed to design a potential multi-epitopes
vaccine against infectious bronchitis virus spike protein (S). Protein
characterization was also per...
Targeted quantitation of CFTR protein expression in vivo using immunoprecipitation & parallel reaction monitoring tandem mass spectrometry
- 2022
Abstract Background The cystic fibrosis transmembrane conductance regulator
(CFTR) protein is a low-abundance membrane protein. The dysfunction of CFTR
protein is the fundamental cause of cystic fibrosis (CF), a fatal genetic
disease. In recent years, the novel messenger RNA (mRNA)-based therapy shows
high potential to treat CF disease, by delivering CFTR mRNA into lung epithelial
cells to generat...
Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran
Tập 4 Số 1 - 2019
AbstractBackgroundColorectal cancer (CRC) can be considered as a result of
multiple risks factors, and the significant role of infectious ones, especially
viral diseases could not be underestimated. Despite endorsed attempts to
identify the accelerating effects of different herpes viridea, such as HSV-1,
HSV2, VZV and CMV on the deterioration of different kinds of malignancy, the
relationship betw...