Translational Medicine Communications
2396-832X
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Các bài báo tiêu biểu
Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstaclesAbstract A rift that has opened up between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and prevention, and this rift is widening and getting deeper. The crisis involving the “translation” of basic scientific findings in a laboratory setting into human applications and potential treatments or biomarkers f... ...
Tập 4 Số 1 - 2019
Adoption of telehealth technologies: an approach to improving healthcare system
Tập 7 - Trang 1-8 - 2022
Globally, the healthcare industry is well known to be one of the strongest drivers of economic growth and development. The sector has gained substantial attention to deal with the fallout of COVID-19, leading to improvement in the quality observed in developed and developing nations. With the advent of the twenty-first century, globalization an ever-growing populace, and environmental changes prom......
The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic reviewAbstract Serotonin or 5-hydroxytryptamine (5-HT)- a neurotransmitter of both the Enteric Nervous System and the Central Nervous System is synthesized by the hydroxylation of L- tryptophan to 5-hydroxytryptophan. Serotonin has been associated with gut functions like assimilation and absorption, alongside the regulation of particle transport and fluid ... ...
- 2021
Comparative molecular cell-of-origin classification of diffuse large B-cell lymphoma based on liquid and tissue biopsiesAbstract
Background
Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtypes have very different clinical courses, with ABC having a much worse s... ...
- 2020
Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot studyAbstract
Background
Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with research in clinical diseases, physiological responses of alarmins to ... ...
- 2020
Targeted quantitation of CFTR protein expression in vivo using immunoprecipitation & parallel reaction monitoring tandem mass spectrometryAbstract
Background
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a low-abundance membrane protein. The dysfunction of CFTR protein is the fundamental cause of cystic fibrosis (CF), a fatal genetic disease. In recent years, the novel messenger RNA (mRNA)-based therapy sho... ...
- 2022
Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approachesAbstract
Background
Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family. This study aimed to design a potential multi-epitopes ... ...
- 2020
Promises of eukaryotic ribonucleases for cancer treatment: a systematic review Abstract
Background
Following an increasing interest in exploration of anticancer chemotherapeutic agents, ribonucleases are currently under investigations for alternative anticancer chemotherapy.
Objective
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