Translational Medicine Communications

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Comparative molecular cell-of-origin classification of diffuse large B-cell lymphoma based on liquid and tissue biopsies
Translational Medicine Communications - - 2020
Ewan Hunter, Ronald McCord, Aroul Ramadass, Jayne Green, Jurjen W. Westra, Kirsten Mundt, Alexandre Akoulitchev
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtypes have very different clinical courses, with ABC having a much worse s...... hiện toàn bộ
Global conserved RBD fraction of SARS-CoV-2 S-protein with T500S mutation in silico significantly blocks ACE2 and rejects viral spike
Translational Medicine Communications - Tập 7 Số 1 - Trang 1-11 - 2022
Banerjee, Amrita, Kanwar, Mehak, Santra, Dipannita, Maiti, Smarajit
SARS-CoV-2 developed global-pandemic with millions of infections/deaths. As it is urgently necessary it is assumed that some blockers/inhibitors of ACE2 could be helpful to resist the binding of viral-spike Receptor-Binding-Domain (RBD). Here, conserved RBD from 186-countries were compared with WUHAN-Hu-1 wild-type (CLUSTAL-X2/Pymol). The RBD of ACE2-bound nCOV2 crystal-structure 6VW1 wa...... hiện toàn bộ
Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction
Translational Medicine Communications - Tập 8 - Trang 1-17 - 2023
Jodie L. Morris, Peter C. McEwen, Hayley L. Letson, Geoffrey P. Dobson
Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) surgery. In other surgical trauma models, ALM therapy has been shown to blunt inflammation, leading to a more permissive healing environment in injured tissues. The purpose of this study was t...... hiện toàn bộ
Global research trends on the links between insulin resistance and obesity: a visualization analysis
Translational Medicine Communications - Tập 7 - Trang 1-13 - 2022
Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun, Samah W. Al-Jabi
Obesity increases the chance of developing insulin resistance. Numerous inflammatory markers have been linked to an increased risk of insulin resistance in obese individuals. Therefore, we performed a bibliometric analysis to determine global research activity and current trends in the field of obesity and insulin resistance. Scopus was used between 2002 and 2021 to retrieve publications related t...... hiện toàn bộ
Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches
Translational Medicine Communications - - 2020
Eman Ali Awadelkareem, Sumaia A. Ali
Abstract Background Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family. This study aimed to design a potential multi-epitopes ...... hiện toàn bộ
Validation of the media fill method for Cytokine-Induced killer cells manufacturing process
Translational Medicine Communications - Tập 8 - Trang 1-13 - 2023
Ivana Ferrero, Sara Castiglia, Aloe Adamini, Alessandra Mandese, Francesca Sismondi, Deborah Rustichelli, Marco Leone, Giuseppe Pinnetta, Lucia Giordanengo, Katia Mareschi, Franca Fagioli
Media fills are used to demonstrate the adequacy of the aseptic conditions of a pharmaceutical production process, according to good manufacturing practice (GMP), using a growth medium in place of the product solution. For advanced therapy medicinal product (ATMP), where the final product consists of viable cells, the media fill is still a challenge, but represents the starting point for process v...... hiện toàn bộ
Phase I clinical trial results of aceneuramic acid for GNE myopathy in Japan
Translational Medicine Communications - Tập 3 - Trang 1-15 - 2018
Naoki Suzuki, Masaaki Kato, Hitoshi Warita, Rumiko Izumi, Maki Tateyama, Hiroshi Kuroda, Ryuta Asada, Akifumi Suzuki, Takuhiro Yamaguchi, Ichizo Nishino, Masashi Aoki
GNE myopathy (distal myopathy with rimmed vacuoles) is a rare intractable muscle disease caused by the mutations in GNE gene, with no therapeutic agents at present. The mutations in GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase) gene result in a deficiency of the biosynthesis of aceneuramic acid. Aceneuramic acid improves the phenotype of GNE myopathy model mice. We examined ...... hiện toàn bộ
Unexpected increase of myocardial extracellular volume fraction in low cardiovascular risk HIV patients
Translational Medicine Communications - Tập 5 - Trang 1-9 - 2020
Iacopo Carbone, Massimiliano Pacilio, Valeria Silvestri, Paolo Vassalini, Eugenio Nelson Cavallari, Cristian Borrazzo, Ornella Spagnolello, Marco Francone, Giancarlo Ceccarelli, Carolina Scagnolari, Letizia Santinelli, Claudio Maria Mastroianni, Gabriella d’Ettorre
People living with HIV (PLWH) are prone to develop sub-clinical Cardiovascular (CV) disease, despite the effectiveness of combined Antiretroviral Therapy (cART). Algorithms developed to predict CV risk in the general population could be inaccurate when applied to PLWH. Myocardial Extra-Cellular Matrix (ECM) expansion, measured by computed tomography, has been associated with an increased CV vulner...... hiện toàn bộ
#Medicine/Public Health #general #Biomedicine
A window of opportunity trial evaluating intratumoral injection of Copaxone® in patients with percutaneously accessible tumors
Translational Medicine Communications - Tập 8 - Trang 1-9 - 2023
Joaquina C. Baranda, Ghulam Rehman Mohyuddin, Andrés M. Bur, Yelizaveta Shnayder, Kyle R. Sweeney, Kiran Kakarala, Megan Prouty, Harsh Pathak, Rajni Puri, Amrita Mitra, Rashna Madan, M. Laird Forrest, Aric Huang, Scott Weir, Andrew K. Godwin, Nabil A. Alhakamy, J. Daniel Griffin, Cory J. Berkland
This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment. Patients with percutaneously accessible malignancies scheduled for surgical resection with curative intent were eligible to participate. Adverse events from one, two, or three injections of Copaxone® were monitored leading up to surgical resection. Usi...... hiện toàn bộ
Characterization of a small molecule modulator of inflammatory cytokine production
Translational Medicine Communications - Tập 7 - Trang 1-15 - 2022
Sagar B Kudchodkar, Paolo Fagone, Omkar U Kawalekar, Moonsup Jeong, Christine C Roberts, Hyojin Lee, Youngran Cho, Areum Gil, Yeeun Oh, Bohyun Jeon, Gee Ho Park, Young K Park, Ferdinando Nicoletti, Joel N Maslow, Kar Muthumani
In the present study, the effect(s) of the immunomodulatory drug GLS-1027 on various cell types involved in inflammation were investigated. GLS-1027 reduced LPS-stimulated secretion of pro-inflammatory cytokines by macrophage or monocytic cells and cell lines. This reduction was likely due in part to decreased activation of NF-κB family transcription factors and inhibition of p38 MAPK signaling in...... hiện toàn bộ
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