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Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle
Tập 2 Số 1 - 2013
Abstract Background The aim of the present study was to determine the influence
of age and habitual activity level, at rest and following a single bout of
high-intensity exercise, on the levels of three proteins poly(ADP-ribose)
polymerase-1 (PARP-1), cleaved-PARP-1 and poly(ADP-ribose) glycohydrolase
(PARG), involved in the DNA repair and cell death responses to stress and
genotoxic insults. Musc...
Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?
Tập 2 Số 1 - 2013
Life-long spontaneous exercise does not prolong lifespan but improves health span in mice
Tập 2 - Trang 1-12 - 2013
Life expectancy at birth in the first world has increased from 35 years at the
beginning of the 20th century to more than 80 years now. The increase in life
expectancy has resulted in an increase in age-related diseases and larger
numbers of frail and dependent people. The aim of our study was to determine
whether life-long spontaneous aerobic exercise affects lifespan and healthspan
in mice. Male...
Transcriptional regulation of Caenorhabditis elegansFOXO/DAF-16 modulates lifespan
Tập 3 - Trang 1-15 - 2014
Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In
C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the
primary target of insulin/IGF-1 signaling, and multiple isoforms of DAF-16 (a,
b, and d/f) modulate lifespan, metabolism, dauer formation, and stress
resistance. Thus far, across phylogeny modulation of mammalian FOXOs and DAF-16
have focused on ...
A relationship exists between replicative senescence and cardiovascular health
Tập 2 - Trang 1-13 - 2013
A growing body of evidence demonstrates that the accumulation of senescent cells
is a plausible ageing mechanism. It has been proposed that the senescence of
vascular cells plays a causal role in the development of cardiovascular
pathologies. A key prediction arising from this hypothesis is that cultures of
cells derived from donors with cardiovascular disease will show reduced in vitro
replicativ...
A midlife crisis for the mitochondrial free radical theory of aging
Tập 3 - Trang 1-15 - 2014
Since its inception more than four decades ago, the Mitochondrial Free Radical
Theory of Aging (MFRTA) has served as a touchstone for research into the biology
of aging. The MFRTA suggests that oxidative damage to cellular macromolecules
caused by reactive oxygen species (ROS) originating from mitochondria
accumulates in cells over an animal’s lifespan and eventually leads to the
dysfunction and f...
Erratum to: Lifespan extension and delay of age-related functional decline caused by Rhodiola roseadepends on dietary macronutrient balance
Tập 2 - Trang 1-1 - 2013
Evidence of changes to skeletal muscle contractile properties during the initiation of disease in the ageing guinea pig model of osteoarthritis
Tập 2 - Trang 1-9 - 2013
Osteoarthritis (OA) is the most common joint disorder in the world and
represents the leading cause of pain and disability in the elderly population.
Advancing age remains the single greatest risk factor for OA. Several studies
have characterised disease development in the guinea pig ageing model of OA in
terms of its joint histopathology and inflammatory cytokine profile. However,
the quadriceps ...