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Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle
Tập 2 Số 1 - 2013
Abstract Background The aim of the present study was to determine the influence
of age and habitual activity level, at rest and following a single bout of
high-intensity exercise, on the levels of three proteins poly(ADP-ribose)
polymerase-1 (PARP-1), cleaved-PARP-1 and poly(ADP-ribose) glycohydrolase
(PARG), involved in the DNA repair and cell death responses to stress and
genotoxic insults. Musc...
Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?
Tập 2 Số 1 - 2013
Transcriptional regulation of Caenorhabditis elegansFOXO/DAF-16 modulates lifespan
Tập 3 - Trang 1-15 - 2014
Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In
C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the
primary target of insulin/IGF-1 signaling, and multiple isoforms of DAF-16 (a,
b, and d/f) modulate lifespan, metabolism, dauer formation, and stress
resistance. Thus far, across phylogeny modulation of mammalian FOXOs and DAF-16
have focused on ...
Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
Tập 2 - Trang 1-9 - 2013
Aging-related loss of muscle mass, a biological process named sarcopenia,
contributes to mobility impairment, falls, and physical frailty, resulting in an
impaired quality of life in older people. In view of the aging of our society,
understanding the underlying mechanisms of sarcopenia is a major health-care
imperative. Evidence obtained from human and rodent studies demonstrates that
skeletal mu...
Life-long spontaneous exercise does not prolong lifespan but improves health span in mice
Tập 2 - Trang 1-12 - 2013
Life expectancy at birth in the first world has increased from 35 years at the
beginning of the 20th century to more than 80 years now. The increase in life
expectancy has resulted in an increase in age-related diseases and larger
numbers of frail and dependent people. The aim of our study was to determine
whether life-long spontaneous aerobic exercise affects lifespan and healthspan
in mice. Male...
Erratum to: Lifespan extension and delay of age-related functional decline caused by Rhodiola roseadepends on dietary macronutrient balance
Tập 2 - Trang 1-1 - 2013
Evidence of changes to skeletal muscle contractile properties during the initiation of disease in the ageing guinea pig model of osteoarthritis
Tập 2 - Trang 1-9 - 2013
Osteoarthritis (OA) is the most common joint disorder in the world and
represents the leading cause of pain and disability in the elderly population.
Advancing age remains the single greatest risk factor for OA. Several studies
have characterised disease development in the guinea pig ageing model of OA in
terms of its joint histopathology and inflammatory cytokine profile. However,
the quadriceps ...
Workshop report: Can an understanding of the mechanisms underlying age-related loss of muscle mass and function guide exercise and other intervention strategies?
Tập 1 - Trang 1-5 - 2012
An international workshop was hosted by the University of Liverpool on 15–16
July 2011 to address at a basic level what is known about the fundamental
mechanisms by which skeletal muscle mass and function are lost during aging and
to examine the nature of interventions that might prevent these mechanistic
changes. Of particular importance was to attempt to evaluate how different forms
of exercise ...