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It is not just muscle mass: a review of muscle quality, composition and metabolism during ageing as determinants of muscle function and mobility in later life
Springer Science and Business Media LLC - - 2014
Robin A. McGregor, David Cameron‐Smith, Sally D. Poppitt
Understanding how we age: insights into inflammaging
Springer Science and Business Media LLC - Tập 2 - Trang 1-8 - 2013
Daniel Baylis, David B Bartlett, Harnish P Patel, Helen C Roberts
Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory. Inflammaging is believed to be a consequence of a remodelling of the innate and acquired immune system, resulting in chronic inflammatory cytokine production. Complex interrelated genetic, environmental and age-related factors determ... hiện toàn bộ
Workshop report: Can an understanding of the mechanisms underlying age-related loss of muscle mass and function guide exercise and other intervention strategies?
Springer Science and Business Media LLC - Tập 1 - Trang 1-5 - 2012
Malcolm J Jackson, Anne McArdle, Aphrodite Vasilaki, Anna Kayani
An international workshop was hosted by the University of Liverpool on 15–16 July 2011 to address at a basic level what is known about the fundamental mechanisms by which skeletal muscle mass and function are lost during aging and to examine the nature of interventions that might prevent these mechanistic changes. Of particular importance was to attempt to evaluate how different forms of exercise ... hiện toàn bộ
Erratum to: Lifespan extension and delay of age-related functional decline caused by Rhodiola roseadepends on dietary macronutrient balance
Springer Science and Business Media LLC - Tập 2 - Trang 1-1 - 2013
Dmytro V Gospodaryov, Ihor S Yurkevych, Oleh V Lushchak, Volodymyr I Lushchak
A midlife crisis for the mitochondrial free radical theory of aging
Springer Science and Business Media LLC - Tập 3 - Trang 1-15 - 2014
Jeffrey A Stuart, Lucas A Maddalena, Max Merilovich, Ellen L Robb
Since its inception more than four decades ago, the Mitochondrial Free Radical Theory of Aging (MFRTA) has served as a touchstone for research into the biology of aging. The MFRTA suggests that oxidative damage to cellular macromolecules caused by reactive oxygen species (ROS) originating from mitochondria accumulates in cells over an animal’s lifespan and eventually leads to the dysfunction and f... hiện toàn bộ
Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle
Springer Science and Business Media LLC - Tập 2 Số 1 - 2013
James N. Cobley, Giorgos K. Sakellariou, Stephen P. Murray, Sarah Waldron, Warren Gregson, Jatin G. Burniston, James P. Morton, Lesley A. Iwanejko, Graeme L. Close
Abstract Background The aim of the present study was to determine the influence of age and habitual activity level, at rest and following a single bout of high-intensity exercise, on the levels of three proteins poly(ADP-ribose) polymerase-1 (PARP-1), cleaved-PARP-1 and poly(ADP-ribose) glycohydrolase (PARG), involved in the DNA repair and cell death responses to stress and genotoxic insults. Musc... hiện toàn bộ
The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators
Springer Science and Business Media LLC - Tập 3 - Trang 1-14 - 2014
Alice de Castro, Fay Minty, Eva Hattinger, Ronald Wolf, Eric Kenneth Parkinson
Replicative senescence is preceded by loss of repeat sequences of DNA from the telomeres that eventually leads to telomere dysfunction, the accumulation of irreparable DNA double strand breaks and a DNA damage response (DDR). However, we have previously reported that whilst telomere dysfunction in human keratinocytes is associated with a permanent cell cycle arrest, the DDR was very weak and trans... hiện toàn bộ
Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model
Springer Science and Business Media LLC - Tập 2 - Trang 1-9 - 2013
Baohua Liu, Shuangcheng Zhou, Xinguang Liu, Keyuan Zhou, Fengju Zhang, Zhongjun Zhou
Alteration in the immune system is one of the most profound aspects of aging. Progressive changes in the number of B lymphocyte progenitors during aging have been reported but the underlying mechanisms are still elusive. A heterozygous G608G mutation in the LMNA gene leads to a deletion of 50 amino acids in lamin A protein, termed progerin, and is the predominant cause of Hutchinson-Gilford proger... hiện toàn bộ
The role of mitochondria in longevity and healthspan
Springer Science and Business Media LLC - Tập 3 - Trang 1-3 - 2014
Martin D Brand
The role of mitochondria in aging and disease remains contentious more than 40 years after the mitochondrial free radical theory of aging was first proposed. As part of a wider cross-journal series on contemporary mitochondrial biology, Longevity & Healthspan presents a thematic series of four reviews that discuss the evidence for and against the modern incarnations of the theory, and examine the ... hiện toàn bộ
Life-long spontaneous exercise does not prolong lifespan but improves health span in mice
Springer Science and Business Media LLC - Tập 2 - Trang 1-12 - 2013
Rebeca Garcia-Valles, Mari Carmen Gomez-Cabrera, Leocadio Rodriguez-Mañas, Francisco J Garcia-Garcia, Ana Diaz, Inma Noguera, Gloria Olaso-Gonzalez, Jose Viña
Life expectancy at birth in the first world has increased from 35 years at the beginning of the 20th century to more than 80 years now. The increase in life expectancy has resulted in an increase in age-related diseases and larger numbers of frail and dependent people. The aim of our study was to determine whether life-long spontaneous aerobic exercise affects lifespan and healthspan in mice. Male... hiện toàn bộ
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