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Beginner’s guide to comparative bacterial genome analysis using next-generation sequence data
Tập 3 Số 1 - 2013
Growth comparison of several Escherichia coli strains exposed to various concentrations of lactoferrin using linear spline regression
- 2012
Abstract Background We wanted to compare growth differences between 13
Escherichia coli strains exposed to various concentrations of the growth
inhibitor lactoferrin in two different types of broth (Syncase and Luria-Bertani
(LB)). To carry this out, we present a simple statistical procedure that
separates microbial growth curves that are due to natural random perturbations
and growth curves that ...
Prediction of a novel RNA binding domain in crocodilepox Zimbabwe Gene 157
Tập 1 - Trang 1-7 - 2011
Although the crocodilepox virus (CRV) is currently unclassified, phylogenetic
analyses suggest that its closest known relatives are molluscum contagiosum
virus (MCV) and the avipox viruses. The CRV genome is approximately 190 kb and
contains a large number of unique genes in addition to the set of conserved
Chordopoxvirus genes found in all such viruses. Upon sequencing the viral
genome, others no...
Where the bugs are: analyzing distributions of bacterial phyla by descriptor keyword search in the nucleotide database
Tập 1 - Trang 1-8 - 2011
The associations between bacteria and environment underlie their preferential
interactions with given physical or chemical conditions. Microbial ecology aims
at extracting conserved patterns of occurrence of bacterial taxa in relation to
defined habitats and contexts. In the present report the NCBI nucleotide
sequence database is used as dataset to extract information relative to the
distribution ...
Deep sequencing of evolving pathogen populations: applications, errors, and bioinformatic solutions
Tập 4 - Trang 1-14 - 2014
Deep sequencing harnesses the high throughput nature of next generation
sequencing technologies to generate population samples, treating information
contained in individual reads as meaningful. Here, we review applications of
deep sequencing to pathogen evolution. Pioneering deep sequencing studies from
the virology literature are discussed, such as whole genome Roche-454 sequencing
analyses of th...
Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli
Tập 1 - Trang 1-20 - 2011
The biochemical and physical factors controlling protein expression level and
solubility in vivo remain incompletely characterized. To gain insight into the
primary sequence features influencing these outcomes, we performed statistical
analyses of results from the high-throughput protein-production pipeline of the
Northeast Structural Genomics Consortium. Proteins expressed in E. coli and
consiste...
Natural genetic engineering: intelligence & design in evolution?
Tập 1 - Trang 1-4 - 2011
There are many things that I like about James Shapiro's new book "Evolution: A
View from the 21st Century" (FT Press Science, 2011). He begins the book by
saying that it is the creation of novelty, and not selection, that is important
in the history of life. In the presence of heritable traits that vary, selection
results in the evolution of a population towards an optimal composition of those
tra...
Metagenomics - Hướng dẫn từ việc lấy mẫu đến phân tích dữ liệu Dịch bởi AI
Tập 2 - Trang 1-12 - 2012
Metagenomics áp dụng một loạt công nghệ gen và công cụ tin sinh học để truy cập
trực tiếp vào nội dung di truyền của toàn bộ cộng đồng sinh vật. Lĩnh vực
metagenomics đã đóng vai trò quan trọng trong việc thúc đẩy tiến bộ đáng kể
trong sinh thái vi sinh vật, tiến hóa và sự đa dạng trong 5 đến 10 năm qua, và
hiện nay nhiều phòng thí nghiệm nghiên cứu đang tích cực tham gia vào lĩnh vực
này. Sự gia ...
#metagenomics #sinh thái vi sinh vật #đa dạng sinh học #công nghệ giải trình tự #phân tích thống kê