Springer Science and Business Media LLC
2042-5783
Cơ quản chủ quản: N/A
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Beginner’s guide to comparative bacterial genome analysis using next-generation sequence data
Tập 3 Số 1 - 2013
Growth comparison of several Escherichia coli strains exposed to various concentrations of lactoferrin using linear spline regression
- 2012
Abstract Background We wanted to compare growth differences between 13
Escherichia coli strains exposed to various concentrations of the growth
inhibitor lactoferrin in two different types of broth (Syncase and Luria-Bertani
(LB)). To carry this out, we present a simple statistical procedure that
separates microbial growth curves that are due to natural random perturbations
and growth curves that ...
Deep sequencing of evolving pathogen populations: applications, errors, and bioinformatic solutions
Tập 4 - Trang 1-14 - 2014
Deep sequencing harnesses the high throughput nature of next generation
sequencing technologies to generate population samples, treating information
contained in individual reads as meaningful. Here, we review applications of
deep sequencing to pathogen evolution. Pioneering deep sequencing studies from
the virology literature are discussed, such as whole genome Roche-454 sequencing
analyses of th...
The Regulatory Network of Pseudomonas aeruginosa
Tập 1 - Trang 1-11 - 2011
Pseudomonas aeruginosa is an important bacterial model due to its metabolic and
pathogenic abilities, which allow it to interact and colonize a wide range of
hosts, including plants and animals. In this work we compile and analyze the
structure and organization of an experimentally supported regulatory network in
this bacterium. The regulatory network consists of 690 genes and 1020 regulatory
inte...
Metagenomics - Hướng dẫn từ việc lấy mẫu đến phân tích dữ liệu Dịch bởi AI
Tập 2 - Trang 1-12 - 2012
Metagenomics áp dụng một loạt công nghệ gen và công cụ tin sinh học để truy cập
trực tiếp vào nội dung di truyền của toàn bộ cộng đồng sinh vật. Lĩnh vực
metagenomics đã đóng vai trò quan trọng trong việc thúc đẩy tiến bộ đáng kể
trong sinh thái vi sinh vật, tiến hóa và sự đa dạng trong 5 đến 10 năm qua, và
hiện nay nhiều phòng thí nghiệm nghiên cứu đang tích cực tham gia vào lĩnh vực
này. Sự gia ...
#metagenomics #sinh thái vi sinh vật #đa dạng sinh học #công nghệ giải trình tự #phân tích thống kê
Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli
Tập 1 - Trang 1-20 - 2011
The biochemical and physical factors controlling protein expression level and
solubility in vivo remain incompletely characterized. To gain insight into the
primary sequence features influencing these outcomes, we performed statistical
analyses of results from the high-throughput protein-production pipeline of the
Northeast Structural Genomics Consortium. Proteins expressed in E. coli and
consiste...
Mycobacterium tuberculosis and Clostridium difficille interactomes: demonstration of rapid development of computational system for bacterial interactome prediction
Tập 2 - Trang 1-12 - 2012
Protein-protein interaction (PPI) networks (interactomes) of most organisms,
except for some model organisms, are largely unknown. Experimental methods
including high-throughput techniques are highly resource intensive. Therefore,
computational discovery of PPIs can accelerate biological discovery by
presenting "most-promising" pairs of proteins that are likely to interact. For
many bacteria, geno...
PerPlot & PerScan: tools for analysis of DNA curvature-related periodicity in genomic nucleotide sequences
Tập 1 - Trang 1-11 - 2011
Periodic spacing of short adenine or thymine runs phased with DNA helical period
of ~10.5 bp is associated with intrinsic DNA curvature and deformability, which
play important roles in DNA-protein interactions and in the organization of
chromosomes in both eukaryotes and prokaryotes. Local differences in DNA
sequence periodicity have been linked to differences in gene expression in some
organisms....