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Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli
Springer Science and Business Media LLC - Tập 1 - Trang 1-20 - 2011
W Nicholson Price, Samuel K Handelman, John K Everett, Saichiu N Tong, Ana Bracic, Jon D Luff, Victor Naumov, Thomas Acton, Philip Manor, Rong Xiao, Burkhard Rost, Gaetano T Montelione, John F Hunt
The biochemical and physical factors controlling protein expression level and solubility in vivo remain incompletely characterized. To gain insight into the primary sequence features influencing these outcomes, we performed statistical analyses of results from the high-throughput protein-production pipeline of the Northeast Structural Genomics Consortium. Proteins expressed in E. coli and consiste...... hiện toàn bộ
The Regulatory Network of Pseudomonas aeruginosa
Springer Science and Business Media LLC - Tập 1 - Trang 1-11 - 2011
Edgardo Galán-Vásquez, Beatriz Luna, Agustino Martínez-Antonio
Pseudomonas aeruginosa is an important bacterial model due to its metabolic and pathogenic abilities, which allow it to interact and colonize a wide range of hosts, including plants and animals. In this work we compile and analyze the structure and organization of an experimentally supported regulatory network in this bacterium. The regulatory network consists of 690 genes and 1020 regulatory inte...... hiện toàn bộ
Prediction of a novel RNA binding domain in crocodilepox Zimbabwe Gene 157
Springer Science and Business Media LLC - Tập 1 - Trang 1-7 - 2011
Nicole S Little, Taylor Quon, Chris Upton
Although the crocodilepox virus (CRV) is currently unclassified, phylogenetic analyses suggest that its closest known relatives are molluscum contagiosum virus (MCV) and the avipox viruses. The CRV genome is approximately 190 kb and contains a large number of unique genes in addition to the set of conserved Chordopoxvirus genes found in all such viruses. Upon sequencing the viral genome, others no...... hiện toàn bộ
Use of the University of Minnesota Biocatalysis/Biodegradation Database for study of microbial degradation
Springer Science and Business Media LLC - Tập 2 - Trang 1-10 - 2012
Lynda BM Ellis, Lawrence P Wackett
Microorganisms are ubiquitous on earth and have diverse metabolic transformative capabilities important for environmental biodegradation of chemicals that helps maintain ecosystem and human health. Microbial biodegradative metabolism is the main focus of the University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD). UM-BBD data has also been used to develop a computational metabolic pa...... hiện toàn bộ
Bioinformatic identification of Mycobacterium tuberculosis proteins likely to target host cell mitochondria: virulence factors?
Springer Science and Business Media LLC - Tập 2 - Trang 1-10 - 2012
María Maximina Bertha Moreno-Altamirano, Iris Selene Paredes-González, Clara Espitia, Mauricio Santiago-Maldonado, Rogelio Hernández-Pando, Francisco Javier Sánchez-García
M. tuberculosis infection either induces or inhibits host cell death, depending on the bacterial strain and the cell microenvironment. There is evidence suggesting a role for mitochondria in these processes. On the other hand, it has been shown that several bacterial proteins are able to target mitochondria, playing a critical role in bacterial pathogenesis and modulation of cell death. However, m...... hiện toàn bộ
Predicted Relative Metabolomic Turnover (PRMT): determining metabolic turnover from a coastal marine metagenomic dataset
Springer Science and Business Media LLC - - 2011
Peter E. Larsen, F. Collart, Dawn Field, Folker Meyer, Kevin P. Keegan, Christopher S. Henry, John W. McGrath, John P. Quinn, Jack A. Gilbert
Metagenomics - Hướng dẫn từ việc lấy mẫu đến phân tích dữ liệu Dịch bởi AI
Springer Science and Business Media LLC - Tập 2 - Trang 1-12 - 2012
Torsten Thomas, Jack Gilbert, Folker Meyer
Metagenomics áp dụng một loạt công nghệ gen và công cụ tin sinh học để truy cập trực tiếp vào nội dung di truyền của toàn bộ cộng đồng sinh vật. Lĩnh vực metagenomics đã đóng vai trò quan trọng trong việc thúc đẩy tiến bộ đáng kể trong sinh thái vi sinh vật, tiến hóa và sự đa dạng trong 5 đến 10 năm qua, và hiện nay nhiều phòng thí nghiệm nghiên cứu đang tích cực tham gia vào lĩnh vực này. Sự gia ...... hiện toàn bộ
#metagenomics #sinh thái vi sinh vật #đa dạng sinh học #công nghệ giải trình tự #phân tích thống kê
Deep sequencing of evolving pathogen populations: applications, errors, and bioinformatic solutions
Springer Science and Business Media LLC - Tập 4 - Trang 1-14 - 2014
Kerensa McElroy, Torsten Thomas, Fabio Luciani
Deep sequencing harnesses the high throughput nature of next generation sequencing technologies to generate population samples, treating information contained in individual reads as meaningful. Here, we review applications of deep sequencing to pathogen evolution. Pioneering deep sequencing studies from the virology literature are discussed, such as whole genome Roche-454 sequencing analyses of th...... hiện toàn bộ
Welcome to Microbial Informatics and Experimentation
Springer Science and Business Media LLC - Tập 1 - Trang 1-1 - 2011
Michael J Wise, Barry L Wanner
Natural genetic engineering: intelligence & design in evolution?
Springer Science and Business Media LLC - Tập 1 - Trang 1-4 - 2011
David W Ussery
There are many things that I like about James Shapiro's new book "Evolution: A View from the 21st Century" (FT Press Science, 2011). He begins the book by saying that it is the creation of novelty, and not selection, that is important in the history of life. In the presence of heritable traits that vary, selection results in the evolution of a population towards an optimal composition of those tra...... hiện toàn bộ
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