Springer Science and Business Media LLC
ESCI-ISI SCOPUS (2016-2023)
2365-421X
Cơ quản chủ quản: Springer Science and Business Media Deutschland GmbH , Springer Nature
Lĩnh vực:
Radiology, Nuclear Medicine and ImagingAnalytical ChemistryPharmacologyPharmacology (medical)
Các bài báo tiêu biểu
Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelatorsAbstract
Background
Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibitor (referred to as UAMC1110) with low nanomolar FA... ...
Tập 5 Số 1 - 2020
Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid targetAbstract Purpose To optimize the direct production of68 Ga on a cyclotron, via the68 Zn(p,n)68 Ga reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced68 Ga, extraction of [68 Ga]GaCl3...
- 2020
Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnologyAbstract Background Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanoparticles for several applications such as imaging, diagnostic, targeted cancer therapy, drug and gene delivery...
Tập 7 Số 1
Ethanol effects on 68Ga-radiolabelling efficacy and radiolysis in automated synthesis utilizing NaCl post-processing
Tập 4 - Trang 1-10 - 2019
Recent studies showed that ethanol in the reaction mixture improves radiolabelling with trivalent radiometals in terms of precursor amount, reaction time, reaction temperature and radiolysis. With regard to clinical application, this effect is of practical interest in radiopharmacy. The aim of this study was to evaluate whether the positive effect of ethanol can be exploited in automated systems u......
Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical productionAbstract
Background
PET radiopharmaceutical development and the implementation of a production method on a synthesis module is a complex and time-intensive task since new synthesis methods must be adapted to the confines of the synthesis platform in use. Commonly utilized single fluid... ...
Tập 4 Số 1 - 2019
Automated, cassette-based isolation and formulation of high-purity [61Cu]CuCl2 from solid Ni targetsAbstract
Background
A need for improved, cassette-based automation of 61 Cu separation from irradiated Ni targets was identified given the growing interest in theranostics, and generally lengthy separation chemistries for 64 Cu/64 Ni, upon which 61 Cu... ...
- 2020
Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPAAbstract The neurotracer 6-[18 F]FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in the diagnosis of other malignancies such as neuroendocrine tumours, pheochromocytoma or pancreatic adenocarcinoma. ...
Tập 6 Số 1