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Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
Springer Science and Business Media LLC - Tập 9 - Trang 1-19 - 2024
Panagiotis Kanellopoulos, Adam Mattsson, Ayman Abouzayed, Karim Obeid, Berthold A. Nock, Vladimir Tolmachev, Theodosia Maina, Anna Orlova
The gastrin-releasing peptide receptor (GRPR) has been extensively studied as a biomolecular target for peptide-based radiotheranostics. However, the lack of metabolic stability and the rapid clearance of peptide radioligands, including radiolabeled GRPR-antagonists, often impede clinical application. Aiming at circumventing these drawbacks, we have designed three new GRPR-antagonist radioligands ...... hiện toàn bộ
Position statement on radiopharmaceutical production for clinical trials
Springer Science and Business Media LLC - Tập 2 Số 1 - 2017
Guy Bormans, Andreas K. Buck, Arturo Chiti, Mandelin Cooper, Jilly Croasdale, Marie-Dominique Desruet, Vikas Kumar, Y. Liu, Iván Peñuelas, Claudio Rossetti, Riccardo Schiavo, Sally W. Schwarz, Albert D. Windhorst
A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
Springer Science and Business Media LLC -
Takayuki Sakai, Aya Ogata, Hiroshi Ikenuma, Takashi Yamada, Saori Hattori, Jiro Abe, Shinichi Imamura, Masanori Ichise, Mari Tada, Akiyoshi Kakita, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, Kengo Ito, Yasuyuki Kimura
Abstract Background Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of neuropathological conditions such as Alzheimer’s disea...... hiện toàn bộ
Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals
Springer Science and Business Media LLC - Tập 7 - Trang 1-29 - 2022
Aruna Korde, Renata Mikolajczak, Petra Kolenc, Penelope Bouziotis, Hadis Westin, Mette Lauritzen, Michel Koole, Matthias Manfred Herth, Manuel Bardiès, Andre F. Martins, Antonio Paulo, Serge K. Lyashchenko, Sergio Todde, Sangram Nag, Efthimis Lamprou, Antero Abrunhosa, Francesco Giammarile, Clemens Decristoforo
The development of radiopharmaceuticals requires extensive evaluation before they can be applied in a diagnostic or therapeutic setting in Nuclear Medicine. Chemical, radiochemical, and pharmaceutical parameters must be established and verified to ensure the quality of these novel products. To provide supportive evidence for the expected human in vivo behaviour, particularly related to safety and...... hiện toàn bộ
Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission
Springer Science and Business Media LLC - Tập 1 - Trang 1-17 - 2016
Maarten Ooms, Sofie Celen, Ronald De Hoogt, Ilse Lenaerts, Johnny Liebregts, Greet Vanhoof, Xavier Langlois, Andrey Postnov, Michel Koole, Alfons Verbruggen, Koen Van Laere, Guy Bormans
Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JNJ42259152 PET to measure changes in PDE10A availability, secondary to pharmacological alterations in DA release and to investigate whether these are D1- or D2-receptor dr...... hiện toàn bộ
Bacterial survival in radiopharmaceutical solutions: a critical impact on current practices
Springer Science and Business Media LLC -
Julien Leenhardt, Luc Choisnard, M. Plasse, Valérie Ardisson, Nicolas De Leiris, Loïc Djaileb, Pierrick Bedouch, Marie-Dominique Brunet
Abstract Background The aim of this brief communication is to highlight the potential bacteriological risk linked to the processes control of radiopharmaceutical preparations made in a radiopharmacy laboratory. Survival rate of Pseudomonas aeruginosa (ATCC: 27...... hiện toàn bộ
Validation of an automated dispensing system for subsequent dose dispensing of different radionuclides
Springer Science and Business Media LLC - Tập 9 - Trang 1-10 - 2024
T. T. Cao, E. A. Aalbersberg, M. M. Geluk-Jonker, J. J. M. A. Hendrikx
Automated dispensing systems (ADSs) for radiopharmaceuticals have been developed to reduce the radiation exposure of personnel, to improve the accuracy of the dispensed dose and to limit the microbiological contamination. However, before implementing such systems, validation according to various applicable guidelines is necessary to ensure safety and quality. Here we present the selection, validat...... hiện toàn bộ
Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?
Springer Science and Business Media LLC - Tập 8 - Trang 1-16 - 2023
Maija Radzina, Laura Saule, Edgars Mamis, Ulli Koester, Thomas Elias Cocolios, Elina Pajuste, Marika Kalnina, Kristaps Palskis, Zoe Sawitzki, Zeynep Talip, Mikael Jensen, Charlotte Duchemin, Kirsten Leufgen, Thierry Stora
In order to support the ongoing research across Europe to facilitate access to novel radionuclides, the PRISMAP consortium (European medical radionuclides programme) was established to offer the broadest catalog of non-conventional radionuclides for medical and translational research. The aim of this article is to introduce readers with current status of novel radionuclides in Europe. A consortium...... hiện toàn bộ
Synthesis of a 2-nitroimidazole derivative N-(4-[18F]fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)-acetamide ([18 F]FBNA) as PET radiotracer for imaging tumor hypoxia
Springer Science and Business Media LLC - - 2022
Arian Pérez Nario, Jenilee Woodfield, Sofia Nascimento dos Santos, Cody Bergman, Melinda Wuest, Yasniel Babí Araújo, A. L. Lapolli, F. G. West, Frank Wuest, Emerson Soares Bernardes
Abstract Background Tissue hypoxia is a pathological condition characterized by reducing oxygen supply. Hypoxia is a hallmark of tumor environment and is commonly observed in many solid tumors. Non-invasive imaging techniques like positron emission tomography (PET) are at the forefront of detecting ...... hiện toàn bộ
A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function
Springer Science and Business Media LLC - Tập 6 - Trang 1-13 - 2021
Lara Garcia-Varela, Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Inês F. Antunes, Chantal Kwizera, Ton J. Visser, Rudi A. J. O. Dierckx, Philip H. Elsinga, Gert Luurtsema
[18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been described in patients with Alzheimer’s or Parkinson’s Disease. The current applied radiosynthesis of [18F]MC225 involves 2 steps, including the distillation of the [18F] fluoroethylbromide interm...... hiện toàn bộ
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