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Potential PET tracers for imaging of tumor-associated macrophages
Springer Science and Business Media LLC - Tập 7 - Trang 1-19 - 2022
Bruna Fernandes, Paula Kopschina Feltes, Carolina Luft, Luiza Reali Nazario, Cristina Maria Moriguchi Jeckel, Ines F. Antunes, Philip H. Elsinga, Erik F. J. de Vries
The increasing incidence of cancer over the years is one of the most challenging problems in healthcare. As cancer progresses, the recruitment of several immune cells is triggered. Infiltration of tumor-associated macrophages (TAMs) is correlated with poor patient prognosis. Since TAMs constitute a big portion of the tumor mass, targeting these cells seems to be an attractive approach for cancer i... hiện toàn bộ
Intravenous and oral copper kinetics, biodistribution and dosimetry in healthy humans studied by [64Cu]copper PET/CT
Springer Science and Business Media LLC - Tập 5 - Trang 1-12 - 2020
Kristoffer Kjærgaard, Thomas Damgaard Sandahl, Kim Frisch, Karina Højrup Vase, Susanne Keiding, Hendrik Vilstrup, Peter Ott, Lars Christian Gormsen, Ole Lajord Munk
Copper is essential for enzymatic processes throughout the body. [64Cu]copper (64Cu) positron emission tomography (PET) has been investigated as a diagnostic tool for certain malignancies, but has not yet been used to study copper homeostasis in humans. In this study, we determined the hepatic removal kinetics, biodistribution and radiation dosimetry of 64Cu in healthy humans by both intravenous a... hiện toàn bộ
Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
Springer Science and Business Media LLC - Tập 9 - Trang 1-19 - 2024
Panagiotis Kanellopoulos, Adam Mattsson, Ayman Abouzayed, Karim Obeid, Berthold A. Nock, Vladimir Tolmachev, Theodosia Maina, Anna Orlova
The gastrin-releasing peptide receptor (GRPR) has been extensively studied as a biomolecular target for peptide-based radiotheranostics. However, the lack of metabolic stability and the rapid clearance of peptide radioligands, including radiolabeled GRPR-antagonists, often impede clinical application. Aiming at circumventing these drawbacks, we have designed three new GRPR-antagonist radioligands ... hiện toàn bộ
Position statement on radiopharmaceutical production for clinical trials
Springer Science and Business Media LLC - Tập 2 Số 1 - 2017
Guy Bormans, Andreas K. Buck, Arturo Chiti, Mandelin Cooper, Jilly Croasdale, Marie-Dominique Desruet, Vikas Kumar, Y. Liu, Iván Peñuelas, Claudio Rossetti, Riccardo Schiavo, Sally W. Schwarz, Albert D. Windhorst
DATATOC: a novel conjugate for kit-type 68Ga labelling of TOC at ambient temperature
Springer Science and Business Media LLC - Tập 1 - Trang 1-12 - 2016
Johanna Seemann, Bradley Waldron, David Parker, Frank Roesch
The widespread acceptance and application of 68Ga-PET depends on our ability to develop radiopharmaceuticals that can be prepared in a convenient and suitable manner. A kit-type labelling protocol provides such characteristics and requires chelators that can be radiolabelled under exceptionally mild conditions. Recently the DATA chelators have been introduced that fulfil these requirements. In con... hiện toàn bộ
A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
Springer Science and Business Media LLC -
Takayuki Sakai, Aya Ogata, Hiroshi Ikenuma, Takashi Yamada, Saori Hattori, Jiro Abe, Shinichi Imamura, Masanori Ichise, Mari Tada, Akiyoshi Kakita, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, Kengo Ito, Yasuyuki Kimura
Abstract Background Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of neuropathological conditions such as Alzheimer’s disease and Lewy body disease, with HSP90, a specific subtype of HSP, playing a key role. Many studies ha... hiện toàn bộ
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Springer Science and Business Media LLC - Tập 8 - Trang 1-18 - 2023
Oliver C. Kiss, Peter J. H. Scott, Martin Behe, Ivan Penuelas, Jan Passchier, Ana Rey, Marianne Patt, Silvio Aime, Amir Jalilian, Peter Laverman, Zhen Cheng, Alain Faivre Chauvet, Jonathan Engle, Frederik Cleeren, Hua Zhu, Johnny Vercouillie, Michael van Dam, Ming Rong Zhang, Lars Perk, Benjamin Guillet, Francisco Alves
The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. This selection of highlights provides commentary on 21 different topics selected by each coauthoring Editorial Board member addressing a variety of aspects ranging from novel radiochemistry to first-in-human applicati... hiện toàn bộ
Production of [211At]NaAt solution under GMP compliance for investigator-initiated clinical trial
Springer Science and Business Media LLC - Tập 9 Số 1
Sadahiro Naka, Kazuhiro Ooe, Yoshifumi Shirakami, Kenta Kurimoto, Toshihiro Sakai, Kazuhiro Takahashi, Atsushi Toyoshima, Yang Wang, Hiromitsu Haba, Hirohisa Kato, Noriyuki Tomiyama, Tadashi Watabe
Abstract Background The alpha emitter astatine-211 (211At) is garnering attention as a novel targeted alpha therapy for patients with refractory thyroid cancer resistant to conventional therapy using beta emitter radioiodine (131I). Herein, we aimed to establish a robust method for the manufacturing and quality control of [211At]NaAt solution for intravenous administration under the good manufactu... hiện toàn bộ
Automated [18F]PSMA-1007 production by a single use cassette-type synthesizer for clinical examination
Springer Science and Business Media LLC - Tập 5 - Trang 1-17 - 2020
Sadahiro Naka, Tadashi Watabe, Kenta Kurimoto, Motohide Uemura, Fumihiko Soeda, Oliver C. Neels, Klaus Kopka, Mitsuaki Tatsumi, Hiroki Kato, Norio Nonomura, Eku Shimosegawa, Jens Cardinale, Frederik L. Giesel, Jun Hatazawa
[18F]PSMA-1007, a positron emission tomography (PET) tracer, specifically targets prostate-specific membrane antigen (PSMA), which is highly expressed in prostate cancer. PSMA-PET is effective especially for regional detection of biochemical recurrence, which significantly affects patient management. Herein, we established and optimized a one-step radiolabeling protocol to separate and purify [18F... hiện toàn bộ
Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer
Springer Science and Business Media LLC - Tập 4 - Trang 1-20 - 2019
Peter Wierstra, Gerwin Sandker, Erik Aarntzen, Martin Gotthardt, Gosse Adema, Johan Bussink, René Raavé, Sandra Heskamp
Immunotherapy with checkpoint inhibitors demonstrates impressive improvements in the treatment of several types of cancer. Unfortunately, not all patients respond to therapy while severe immune-related adverse effects are prevalent. Currently, patient stratification is based on immunotherapy marker expression through immunohistochemical analysis on biopsied material. However, expression can be het... hiện toàn bộ
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