Medicinal Research Reviews
SCOPUS (SonsInc.)SCIE-ISI
0198-6325
1098-1128
Mỹ
Cơ quản chủ quản: John Wiley & Sons Inc. , WILEY
Lĩnh vực:
PharmacologyMolecular MedicineDrug Discovery
Các bài báo tiêu biểu
Small Molecule Modulators of K eap1‐N rf2‐ARE Pathway as Potential Preventive and Therapeutic AgentsAbstract K elch‐like ECH ‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N rf2)‐antioxidant resp...
Tập 32 Số 4 - Trang 687-726 - 2012
Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry
Tập 34 Số 2 - Trang 340-437 - 2014
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infectionAbstract 3β‐Hydroxy‐lup‐20(29)‐en‐28‐oic acid (betulinic acid) is a pentacyclic lupane‐type triterpene that is widely distributed throughout the plant kingdom. A variety of biological activities have been ascribed to betulinic acid including anti‐inflammatory and in vitro antimalarial effects. However, betulinic acid is most highly regarde... ...
Tập 24 Số 1 - Trang 90-114 - 2004
Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancersAbstract Specific and sensitive non‐invasive biomarkers for the detection of human epithelial malignancies are urgently required to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are 19–24 nt noncoding RNAs that are frequently dysregulated in cancer and have shown great promise as tissue‐based markers for cancer classification. Onc... ...
Tập 32 Số 2 - Trang 326-348 - 2012
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's diseaseWith 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to nations. Unless a new medicine capable to delay disease progression is found, the number of cases will reach 107 million in 2050. So far, the therapeutic paradigm one‐compound‐one‐target has failed. This could be due to the multiple pat... ...
Tập 33 Số 1 - Trang 139-189 - 2013
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interestAbstract A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of pathophysiological conditions occurring in humans is here provided. Despite an active, now well characterized, metabolism in most cells and tissues, HNE can be easily detected and quantified by means of several methods, although with different sensitivity. Measurements of ... ...
Tập 28 Số 4 - Trang 569-631 - 2008
Selection criteria for drug‐like compoundsAbstract The fast identification of quality lead compounds in the pharmaceutical industry through a combination of high throughput synthesis and screening has become more challenging in recent years. Although the number of available compounds for high throughput screening (HTS) has dramatically increased, large‐scale random combinatorial libraries have contributed p... ...
Tập 23 Số 3 - Trang 302-321 - 2003
The chemistry, pharmacology, and clinical applications of qinghaosu (Artemisinin) and its derivatives
Tập 7 Số 1 - Trang 29-52 - 1987