Medicinal Research Reviews
SCOPUS (1981-2025)SCIE-ISI
0198-6325
1098-1128
Mỹ
Cơ quản chủ quản: John Wiley & Sons Inc. , WILEY
Lĩnh vực:
PharmacologyMolecular MedicineDrug Discovery
Các bài báo tiêu biểu
Small Molecule Modulators of K eap1‐N rf2‐ARE Pathway as Potential Preventive and Therapeutic Agents
Tập 32 Số 4 - Trang 687-726 - 2012
AbstractKelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid
2‐related factor 2 (Nrf2)‐antioxidant response elements (ARE) pathway represents
one of the most important cellular defense mechanisms against oxidative stress
and xenobiotic damage. Activation of Nrf2 signaling induces the transcriptional
regulation of ARE‐dependent expression of various detoxifying and antioxidant
defen...
Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry
Tập 34 Số 2 - Trang 340-437 - 2014
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
Tập 24 Số 1 - Trang 90-114 - 2004
Abstract3β‐Hydroxy‐lup‐20(29)‐en‐28‐oic acid (betulinic acid) is a pentacyclic
lupane‐type triterpene that is widely distributed throughout the plant kingdom.
A variety of biological activities have been ascribed to betulinic acid
including anti‐inflammatory and in vitro antimalarial effects. However,
betulinic acid is most highly regarded for its anti‐HIV‐1 activity and specific
cytotoxicity agai...
Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers
Tập 32 Số 2 - Trang 326-348 - 2012
AbstractSpecific and sensitive non‐invasive biomarkers for the detection of
human epithelial malignancies are urgently required to reduce the worldwide
morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are 19–24 nt
noncoding RNAs that are frequently dysregulated in cancer and have shown great
promise as tissue‐based markers for cancer classification. Once thought to be
unstable RNA mole...
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
Tập 33 Số 1 - Trang 139-189 - 2013
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD)
constitutes an overwhelming health, social, economic, and political problem to
nations. Unless a new medicine capable to delay disease progression is found,
the number of cases will reach 107 million in 2050. So far, the therapeutic
paradigm one‐compound‐one‐target has failed. This could be due to the multiple
pathogenic ...
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
Tập 28 Số 4 - Trang 569-631 - 2008
AbstractA comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in
a variety of pathophysiological conditions occurring in humans is here provided.
Despite an active, now well characterized, metabolism in most cells and tissues,
HNE can be easily detected and quantified by means of several methods, although
with different sensitivity. Measurements of HNE and/or stable metabolites in
...
Selection criteria for drug‐like compounds
Tập 23 Số 3 - Trang 302-321 - 2003
AbstractThe fast identification of quality lead compounds in the pharmaceutical
industry through a combination of high throughput synthesis and screening has
become more challenging in recent years. Although the number of available
compounds for high throughput screening (HTS) has dramatically increased,
large‐scale random combinatorial libraries have contributed proportionally less
to identify no...
The chemistry, pharmacology, and clinical applications of qinghaosu (Artemisinin) and its derivatives
Tập 7 Số 1 - Trang 29-52 - 1987