Medicinal Research Reviews
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Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation
Medicinal Research Reviews - Tập 12 Số 5 - Trang 525-562 - 1992
Recent Developments in Chimeric NSAIDs as Safer Anti‐Inflammatory AgentsAbstract NSAIDs are among the most widely prescribed medications across the world, but the gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current NSAIDs‐based therapeutics. The development of selective COX‐2 inhibitors was driven by the assumption that selective inhibition of COX‐2 would reduce the GI side effects. However, th... ...
Medicinal Research Reviews - Tập 35 Số 2 - Trang 341-407 - 2015
Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)Abstract Huang‐Qi (Astragali Radix) is an herbal tonic widely used in China and many other countries. It is derived from the roots of Astragalus membranaceus and A. membranaceus var. mongholicus and shows potent cardiovascular protective effects. In this article, we comprehensively revi... ...
Medicinal Research Reviews - Tập 41 Số 4 - Trang 1999-2038 - 2021
Chemical regulation of epigenetic modifications: Opportunities for new cancer therapyAbstract Epigenetics is concerned about heritable changes in gene expression without alteration of the coding sequence. Epigenetic modification of chromatin includes methylation of genomic DNA as well as post‐translational modification of chromatin‐associated proteins, in particular, histones. The spectrum of histone and non‐histone modifications ranges from the add... ...
Medicinal Research Reviews - Tập 28 Số 5 - Trang 645-687 - 2008
Selection criteria for drug‐like compoundsAbstract The fast identification of quality lead compounds in the pharmaceutical industry through a combination of high throughput synthesis and screening has become more challenging in recent years. Although the number of available compounds for high throughput screening (HTS) has dramatically increased, large‐scale random combinatorial libraries have contributed p... ...
Medicinal Research Reviews - Tập 23 Số 3 - Trang 302-321 - 2003
Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic targetAbstract Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cell... ...
Medicinal Research Reviews - Tập 39 Số 1 - Trang 70-113 - 2019
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseasesAbstract Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale... ...
Medicinal Research Reviews - Tập 41 Số 1 - Trang 630-703 - 2021
Glycosylated neuropeptides: A new vista for neuropsychopharmacology?Abstract The application of endogenous neuropeptides (e.g., enkephalins) as analgesics has been retarded by their poor stability in vivo and by their inability to effectively penetrate the blood–brain barrier (BBB). Effective BBB transport of glycosylated enkephalins has been demonstrated in several labs now. Analgesia (antinociception) le... ...
Medicinal Research Reviews - Tập 25 Số 5 - Trang 557-585 - 2005
Interactions of monoamine oxidase with substrates and inhibitors
Medicinal Research Reviews - Tập 9 Số 1 - Trang 45-89 - 1989
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