Medicinal Research Reviews
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Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation
Medicinal Research Reviews - Tập 12 Số 5 - Trang 525-562 - 1992
Recent Developments in Chimeric NSAIDs as Safer Anti‐Inflammatory Agents
Medicinal Research Reviews - Tập 35 Số 2 - Trang 341-407 - 2015
AbstractNSAIDs are among the most widely prescribed medications across the
world, but the gastrointestinal (GI) toxicity still remains the biggest problem
and the challenge for current NSAIDs‐based therapeutics. The development of
selective COX‐2 inhibitors was driven by the assumption that selective
inhibition of COX‐2 would reduce the GI side effects. However, the initial
enthusiasm for selectiv...
Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)
Medicinal Research Reviews - Tập 41 Số 4 - Trang 1999-2038 - 2021
AbstractHuang‐Qi (Astragali Radix) is an herbal tonic widely used in China and
many other countries. It is derived from the roots of Astragalus membranaceus
and A. membranaceus var. mongholicus and shows potent cardiovascular protective
effects. In this article, we comprehensively reviewed 189 small molecules
isolated from the two Astragalus species and discussed the interspecies chemical
differen...
Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy
Medicinal Research Reviews - Tập 28 Số 5 - Trang 645-687 - 2008
AbstractEpigenetics is concerned about heritable changes in gene expression
without alteration of the coding sequence. Epigenetic modification of chromatin
includes methylation of genomic DNA as well as post‐translational modification
of chromatin‐associated proteins, in particular, histones. The spectrum of
histone and non‐histone modifications ranges from the addition of relatively
small groups ...
Selection criteria for drug‐like compounds
Medicinal Research Reviews - Tập 23 Số 3 - Trang 302-321 - 2003
AbstractThe fast identification of quality lead compounds in the pharmaceutical
industry through a combination of high throughput synthesis and screening has
become more challenging in recent years. Although the number of available
compounds for high throughput screening (HTS) has dramatically increased,
large‐scale random combinatorial libraries have contributed proportionally less
to identify no...
Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target
Medicinal Research Reviews - Tập 39 Số 1 - Trang 70-113 - 2019
AbstractSince reprogramming energy metabolism is considered a new hallmark of
cancer, tumor metabolism is again in the spotlight of cancer research. Many
studies have been carried out and many possible therapies have been developed in
the last years. However, tumor cells are not alone. A series of extracellular
components and stromal cells, such as endothelial cells, cancer‐associated
fibroblasts,...
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases
Medicinal Research Reviews - Tập 41 Số 1 - Trang 630-703 - 2021
AbstractAdaptogens comprise a category of herbal medicinal and nutritional
products promoting adaptability, resilience, and survival of living organisms in
stress. The aim of this review was to summarize the growing knowledge about
common adaptogenic plants used in various traditional medical systems (TMS) and
conventional medicine and to provide a modern rationale for their use in the
treatment o...
Glycosylated neuropeptides: A new vista for neuropsychopharmacology?
Medicinal Research Reviews - Tập 25 Số 5 - Trang 557-585 - 2005
AbstractThe application of endogenous neuropeptides (e.g., enkephalins) as
analgesics has been retarded by their poor stability in vivo and by their
inability to effectively penetrate the blood–brain barrier (BBB). Effective BBB
transport of glycosylated enkephalins has been demonstrated in several labs now.
Analgesia (antinociception) levels greater than morphine, and with reduced side
effects ha...
Interactions of monoamine oxidase with substrates and inhibitors
Medicinal Research Reviews - Tập 9 Số 1 - Trang 45-89 - 1989
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