Interactions of monoamine oxidase with substrates and inhibitors

Medicinal Research Reviews - Tập 9 Số 1 - Trang 45-89 - 1989
P. Dostert1,2, M. Strolin Benedetti1,3,4, Keith F. Tipton5,6,7
1Farmitalia Carlo Erba, R & D, Via Imbonati 24, 20159, Milan, Italy
2Philippe L. Dostert: , Ph.D., is Head of a group of Medicinal Chemistry at Farmitalia Carlo Erba, Milan, Italy. His main interests in research lie in the field of drugs acting on the central nervous system: antidepressants (MAO inhibitors in particular), neuroleptics, anticonvulsants, and drugs acting to prevent degenerative processes in the CNS.
3Margherita Strolin Benedetti: , Ph.D., is Head of the Department of Metabolism and Pharmacokinetics at Farmitalia Carlo Erba, Milan, Italy. Her research interests lie mainly in the field of drugs capable of metabolizing enzymes
4particularly the involvement of peripheral and central amine oxidases in the metabolism of xenobiotics and lipid peroxidation.
5Department of Biochemistry, Trinity College, Dublin, 2, Ireland
6Keith F. Tipton: , M.A. Ph.D., is Professor of Biochemistry at Trinity College, Dublin, Ireland. Formerly he was lecturer in Biochemistry at Cambridge University, Cambridge, England. His research interests lie mainly in the fields of enzymology and neurochemistry
7his particular interest is the functions and inhibition of enzymes involved in neurotransmitter metabolism.

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Medicinal Research Reviews

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