The Short Form of the Geriatric Depression Scale: A Comparison With the 30-Item Form Tập 4 Số 3 - Trang 173-178 - 1991
W. J. Burke, William H. Roccaforte, Steven P. Wengel
The Geriatric Depression Scale (GDS) exists in both short and long forms. The original 30-item form of the GDS has been shown to be an effective screening test for depression in a variety of settings. However, its utility in patients with demen tia of the Alzheimer type (DAT) is questionable. The short, 15-item version of the GDS was developed primarily for brev ity and, in particular, fo...... hiện toàn bộ
Sleep Problems and Institutionalization of the Elderly Tập 4 Số 4 - Trang 204-210 - 1991
Charles P. Pollak, Deborah Perlick
This study examined the role of sleep problems in the decisions of families to institutionalize elderly relatives. Previous work on institutionalization of the elderly has given little attention to the contribution of nocturnal, sleep-related problems. Seventy-three primary caregivers of elders recently admitted to a nursing home or psychiatric hospital were asked to identify the problems...... hiện toàn bộ
Cognitive Impairment in Parkinson Disease Tập 25 Số 4 - Trang 208-214 - 2012
Iracema Leroi, Kathryn McDonald, Hiranmayi Pantula, Vijay Harbishettar
Aim: To compare quality of life, level of disability, and caregiver burden in 3 groups of people with Parkinson disease (PD): those with mild cognitive impairment (PD-MCI), those with dementia (PDD), and those with no cognitive impairment (PD-NC). Background: Although the cognitive profile of ...... hiện toàn bộ
Effects of Cognitive Challenge on Gait Variability in Patients with Parkinson’s Disease Tập 16 Số 1 - Trang 53-58 - 2003
Jeffrey M. Hausdorff, Jackov Balash, Nir Giladi
Attention plays an important role in the gait disturbances of patients with Parkinson’s disease (PD); however, the effects of “dual tasking” on fall risk and gait instability have not been well studied. The authors tested the hypothesis that gait variability increases when subjects with PD walk while performing a cognitively challenging task (CCT). Subjects with idiopathic PD walked under...... hiện toàn bộ
Neuropsychological Prediction of Decline to Dementia in Nondemented Elderly Tập 12 Số 4 - Trang 168-179 - 1999
Alan Kluger, Mary Sano, James Golomb, Mary Mittelman, Barry Reisberg
This study examined whether baseline neuropsychological performance in elderly assessed at a research clinic could accurately predict subsequent decline to dementia. Logistic regression analyses were applied to (1) 213 nondemented elderly with a Global Deterioration Scale (GDS) score of 1, 2, or 3, of whom 74 (35%) subsequently declined to any diagnosis of dementia, and (2) a diagnostical...... hiện toàn bộ
Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression Tập 18 Số 4 - Trang 218-223 - 2005
James A. Mortimer, Amy R. Borenstein, Karen M. Gosche, David A. Snowdon
Numerous studies show that the pathology of Alzheimer’s disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer’s disease, it will be important to detect preclinical Alzheimer’s disease as early as possible for maximal treatment effect. Detection of...... hiện toàn bộ
Depression and Anxiety in Parkinson's Disease: Possible Effect of Genetic Variation in the Serotonin Transporter Tập 12 Số 2 - Trang 49-52 - 1999
Matthew Menza, Brandon Palermo, Rocco DiPaola, Jacob I. Sage, Michael Ricketts
Recently, a functional polymorphism in the promoter region of the serotonin transporter gene has been linked to anxiety. In cell culture, the short allele of this polymorphism synthesizes less serotonin transporter, resulting in a reduction of the removal of serotonin from the synaptic cleft. This pilot study examines depression and anxiety in Parkinson's disease patients as a function of...... hiện toàn bộ
MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review Tập 20 Số 1 - Trang 3-21 - 2007
Ludovico Minati, Marina Grisoli, Maria Grazia Bruzzone
In vivo magnetic resonance spectroscopy (MRS), functional magnetic resonance imaging (fMRI), and diffusion-tensor imaging (DTI) have recently opened new possibilities for noninvasively assessing the metabolic, functional, and connectivity correlates of aging in research and clinical settings. The purpose of this article is to provide a conceptual review intended for a multidisciplinary au...... hiện toàn bộ
When One Loses Empathy Tập 26 Số 3 - Trang 174-184 - 2013
Sharpley Hsieh, Muireann Irish, Naomi Daveson, John R. Hodges, Olivier Piguet
The effects of empathy loss in frontotemporal dementia (FTD) and Alzheimer disease (AD) on carer symptomatology were investigated. Carers of patients with 2 clinical subtypes of FTD (behavioral-variant FTD [bvFTD] = 18; semantic dementia [SD] = 14) and AD (n = 18) completed the Interpersonal Reactivity Index (IRI), a standardized questionnaire of empathy as well as a measure of perceived ...... hiện toàn bộ