Journal of Geriatric Psychiatry and Neurology

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The Effect of Ischemic Cholinergic Damage on Cognition in Patients With Subcortical Vascular Cognitive Impairment
Journal of Geriatric Psychiatry and Neurology - Tập 25 Số 2 - Trang 122-127 - 2012
Sook Hui Kim, Hyun Seok Kang, Han Jo Kim, Yeonsil Moon, Hui Jin Ryu, Min Young Kim, Seol‐Heui Han
Prior research has shown that the total amount of white matter ischemia had no significant correlation with cognitive deficits. We compared the association of white matter hyperintensities (WMHs) of total as well as cholinergic pathways with clinical dementia severity and investigated whether cholinergic ischemic burden had an independent predictive value with respect to cognitive decline...... hiện toàn bộ
Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression
Journal of Geriatric Psychiatry and Neurology - Tập 18 Số 4 - Trang 218-223 - 2005
James A. Mortimer, Amy R. Borenstein, Karen M. Gosche, David A. Snowdon
Numerous studies show that the pathology of Alzheimer’s disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer’s disease, it will be important to detect preclinical Alzheimer’s disease as early as possible for maximal treatment effect. Detection of...... hiện toàn bộ
Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar Disorder
Journal of Geriatric Psychiatry and Neurology - Tập 27 Số 1 - Trang 56-62 - 2014
Changtae Hahn, Hyun Kook Lim, Chang Uk Lee
In recent years, there has been an increasing interest in late-onset mental disorders. Among them, geriatric schizophrenia and bipolar disorder are significant health care risks and major causes of disability. We discussed whether late-onset schizophrenia (LOS) and late-onset bipolar (LOB) disorder can be a separate entity from early-onset schizophrenia (EOS) and early-onset bipolar (EOB)...... hiện toàn bộ
When One Loses Empathy
Journal of Geriatric Psychiatry and Neurology - Tập 26 Số 3 - Trang 174-184 - 2013
Sharpley Hsieh, Muireann Irish, Naomi Daveson, John R. Hodges, Olivier Piguet
The effects of empathy loss in frontotemporal dementia (FTD) and Alzheimer disease (AD) on carer symptomatology were investigated. Carers of patients with 2 clinical subtypes of FTD (behavioral-variant FTD [bvFTD] = 18; semantic dementia [SD] = 14) and AD (n = 18) completed the Interpersonal Reactivity Index (IRI), a standardized questionnaire of empathy as well as a measure of perceived ...... hiện toàn bộ
Neuropsychological Prediction of Decline to Dementia in Nondemented Elderly
Journal of Geriatric Psychiatry and Neurology - Tập 12 Số 4 - Trang 168-179 - 1999
Alan Kluger, Mary Sano, James Golomb, Mary Mittelman, ‌Barry Reisberg
This study examined whether baseline neuropsychological performance in elderly assessed at a research clinic could accurately predict subsequent decline to dementia. Logistic regression analyses were applied to (1) 213 nondemented elderly with a Global Deterioration Scale (GDS) score of 1, 2, or 3, of whom 74 (35%) subsequently declined to any diagnosis of dementia, and (2) a diagnostical...... hiện toàn bộ
Effects of Cognitive Challenge on Gait Variability in Patients with Parkinson’s Disease
Journal of Geriatric Psychiatry and Neurology - Tập 16 Số 1 - Trang 53-58 - 2003
Jeffrey M. Hausdorff, Jackov Balash, Nir Giladi
Attention plays an important role in the gait disturbances of patients with Parkinson’s disease (PD); however, the effects of “dual tasking” on fall risk and gait instability have not been well studied. The authors tested the hypothesis that gait variability increases when subjects with PD walk while performing a cognitively challenging task (CCT). Subjects with idiopathic PD walked under...... hiện toàn bộ
Cognitive Impairment in Parkinson Disease
Journal of Geriatric Psychiatry and Neurology - Tập 25 Số 4 - Trang 208-214 - 2012
Iracema Leroi, Kathryn McDonald, Hiranmayi Pantula, Vijay Harbishettar
Aim: To compare quality of life, level of disability, and caregiver burden in 3 groups of people with Parkinson disease (PD): those with mild cognitive impairment (PD-MCI), those with dementia (PDD), and those with no cognitive impairment (PD-NC). Background: Although the cognitive profile of ...... hiện toàn bộ
Middle-Aged Children of Persons With Alzheimer’s Disease: APOE Genotypes and Cognitive Function in the Wisconsin Registry for Alzheimer’s Prevention
Journal of Geriatric Psychiatry and Neurology - Tập 18 Số 4 - Trang 245-249 - 2005
Pau Pástor, Bruce P. Hermann, Asenath La Rue
Adult children of persons with Alzheimer’s disease are at increased risk of developing Alzheimer’s disease because of hereditary, environmental, and health risk factors shared with affected parents. The Wisconsin Registry for Alzheimer’s Prevention (WRAP) has completed baseline assessments on 452 middle-aged persons (mean = 53 years) who have at least 1 parent with AD. Forty-five percent ...... hiện toàn bộ
Leisure Activities and Risk of Vascular Cognitive Impairment in Older Adults
Journal of Geriatric Psychiatry and Neurology - Tập 22 Số 2 - Trang 110-118 - 2009
Joe Verghese, Cuiling Wang, Mindy J. Katz, Amy E. Sanders, Richard B. Lipton
``Vascular cognitive impairment'' refers to cognitive impairment caused or associated with vascular risk factors, and encompasses a cognitive spectrum ranging from mild cognitive impairment to dementia. We examined the association of leisure activity participation to risk of developing VCI in the Bronx aging study. Over 21 years, 71 of the 401 participants who were free of dementia or VCI...... hiện toàn bộ
Sleep Problems and Institutionalization of the Elderly
Journal of Geriatric Psychiatry and Neurology - Tập 4 Số 4 - Trang 204-210 - 1991
Charles P. Pollak, Deborah Perlick
This study examined the role of sleep problems in the decisions of families to institutionalize elderly relatives. Previous work on institutionalization of the elderly has given little attention to the contribution of nocturnal, sleep-related problems. Seventy-three primary caregivers of elders recently admitted to a nursing home or psychiatric hospital were asked to identify the problems...... hiện toàn bộ
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