Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical ExpressionJournal of Geriatric Psychiatry and Neurology - Tập 18 Số 4 - Trang 218-223 - 2005
James A. Mortimer, Amy R. Borenstein, Karen M. Gosche, David A. Snowdon
Numerous studies show that the pathology of Alzheimer’s disease is present
decades before a clinical diagnosis of dementia can be made. Given the
likelihood that agents will become available that reliably delay onset and/or
slow progression of Alzheimer’s disease, it will be important to detect
preclinical Alzheimer’s disease as early as possible for maximal treatment
effect. Detection of individu... hiện toàn bộ
Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar DisorderJournal of Geriatric Psychiatry and Neurology - Tập 27 Số 1 - Trang 56-62 - 2014
Changtae Hahn, Hyun Kook Lim, Chang Uk Lee
In recent years, there has been an increasing interest in late-onset mental
disorders. Among them, geriatric schizophrenia and bipolar disorder are
significant health care risks and major causes of disability. We discussed
whether late-onset schizophrenia (LOS) and late-onset bipolar (LOB) disorder can
be a separate entity from early-onset schizophrenia (EOS) and early-onset
bipolar (EOB) disorder... hiện toàn bộ
When One Loses EmpathyJournal of Geriatric Psychiatry and Neurology - Tập 26 Số 3 - Trang 174-184 - 2013
Sharpley Hsieh, Muireann Irish, Naomi Daveson, John R. Hodges, Olivier Piguet
The effects of empathy loss in frontotemporal dementia (FTD) and Alzheimer
disease (AD) on carer symptomatology were investigated. Carers of patients with
2 clinical subtypes of FTD (behavioral-variant FTD [bvFTD] = 18; semantic
dementia [SD] = 14) and AD (n = 18) completed the Interpersonal Reactivity Index
(IRI), a standardized questionnaire of empathy as well as a measure of perceived
burden (Z... hiện toàn bộ
Neuropsychological Prediction of Decline to Dementia in Nondemented ElderlyJournal of Geriatric Psychiatry and Neurology - Tập 12 Số 4 - Trang 168-179 - 1999
Alan Kluger, Mary Sano, James Golomb, Mary Mittelman, Barry Reisberg
This study examined whether baseline neuropsychological performance in elderly
assessed at a research clinic could accurately predict subsequent decline to
dementia. Logistic regression analyses were applied to (1) 213 nondemented
elderly with a Global Deterioration Scale (GDS) score of 1, 2, or 3, of whom 74
(35%) subsequently declined to any diagnosis of dementia, and (2) a
diagnostically more r... hiện toàn bộ
Effects of Cognitive Challenge on Gait Variability in Patients with Parkinson’s DiseaseJournal of Geriatric Psychiatry and Neurology - Tập 16 Số 1 - Trang 53-58 - 2003
Jeffrey M. Hausdorff, Jackov Balash, Nir Giladi
Attention plays an important role in the gait disturbances of patients with
Parkinson’s disease (PD); however, the effects of “dual tasking” on fall risk
and gait instability have not been well studied. The authors tested the
hypothesis that gait variability increases when subjects with PD walk while
performing a cognitively challenging task (CCT). Subjects with idiopathic PD
walked under normal c... hiện toàn bộ
Cognitive Impairment in Parkinson DiseaseJournal of Geriatric Psychiatry and Neurology - Tập 25 Số 4 - Trang 208-214 - 2012
Iracema Leroi, Kathryn McDonald, Hiranmayi Pantula, Vijay Harbishettar
Aim: To compare quality of life, level of disability, and caregiver burden in 3
groups of people with Parkinson disease (PD): those with mild cognitive
impairment (PD-MCI), those with dementia (PDD), and those with no cognitive
impairment (PD-NC). Background: Although the cognitive profile of those with
PD-MCI and PDD has been well described, little is known about the personal and
clinical impact ... hiện toàn bộ
Leisure Activities and Risk of Vascular Cognitive Impairment in Older AdultsJournal of Geriatric Psychiatry and Neurology - Tập 22 Số 2 - Trang 110-118 - 2009
Joe Verghese, Cuiling Wang, Mindy J. Katz, Amy E. Sanders, Richard B. Lipton
``Vascular cognitive impairment'' refers to cognitive impairment caused or
associated with vascular risk factors, and encompasses a cognitive spectrum
ranging from mild cognitive impairment to dementia. We examined the association
of leisure activity participation to risk of developing VCI in the Bronx aging
study. Over 21 years, 71 of the 401 participants who were free of dementia or
VCI at entry... hiện toàn bộ
Sleep Problems and Institutionalization of the ElderlyJournal of Geriatric Psychiatry and Neurology - Tập 4 Số 4 - Trang 204-210 - 1991
Charles P. Pollak, Deborah Perlick
This study examined the role of sleep problems in the decisions of families to
institutionalize elderly relatives. Previous work on institutionalization of the
elderly has given little attention to the contribution of nocturnal,
sleep-related problems. Seventy-three primary caregivers of elders recently
admitted to a nursing home or psychiatric hospital were asked to identify the
problems the elde... hiện toàn bộ
Lexical Processing in Parkinson's Disease and Multiple SclerosisJournal of Geriatric Psychiatry and Neurology - Tập 2 Số 3 - Trang 145-152 - 1989
William W. Beatty, Nancy Monson
Patients with Parkinson's disease (PD) or multiple sclerosis (MS) were
categorized as normal in naming (NN) or impaired in naming (IN) based on their
performance on the Boston Naming Test. All patients scored at least 23 on the
Mini-Mental State Examination. Both PDIN and MSIN patient groups exhibited poor
naming performance when target words were elicited with semantic, visual or
rhyming cues. Th... hiện toàn bộ