Journal of Geriatric Psychiatry and Neurology

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The Effect of Ischemic Cholinergic Damage on Cognition in Patients With Subcortical Vascular Cognitive Impairment
Journal of Geriatric Psychiatry and Neurology - Tập 25 Số 2 - Trang 122-127 - 2012
Sook Hui Kim, Hyun Seok Kang, Han Jo Kim, Yeonsil Moon, Hui Jin Ryu, Min Young Kim, Seol‐Heui Han
Prior research has shown that the total amount of white matter ischemia had no significant correlation with cognitive deficits. We compared the association of white matter hyperintensities (WMHs) of total as well as cholinergic pathways with clinical dementia severity and investigated whether cholinergic ischemic burden had an independent predictive value with respect to cognitive decline...... hiện toàn bộ
Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar Disorder
Journal of Geriatric Psychiatry and Neurology - Tập 27 Số 1 - Trang 56-62 - 2014
Changtae Hahn, Hyun Kook Lim, Chang Uk Lee
In recent years, there has been an increasing interest in late-onset mental disorders. Among them, geriatric schizophrenia and bipolar disorder are significant health care risks and major causes of disability. We discussed whether late-onset schizophrenia (LOS) and late-onset bipolar (LOB) disorder can be a separate entity from early-onset schizophrenia (EOS) and early-onset bipolar (EOB)...... hiện toàn bộ
Neuropsychological Prediction of Decline to Dementia in Nondemented Elderly
Journal of Geriatric Psychiatry and Neurology - Tập 12 Số 4 - Trang 168-179 - 1999
Alan Kluger, Mary Sano, James Golomb, Mary Mittelman, ‌Barry Reisberg
This study examined whether baseline neuropsychological performance in elderly assessed at a research clinic could accurately predict subsequent decline to dementia. Logistic regression analyses were applied to (1) 213 nondemented elderly with a Global Deterioration Scale (GDS) score of 1, 2, or 3, of whom 74 (35%) subsequently declined to any diagnosis of dementia, and (2) a diagnostical...... hiện toàn bộ
Prevalence of Depression and Anxiety in Parkinson Disease and Impact on Quality of Life: A Community-Based Study in Spain
Journal of Geriatric Psychiatry and Neurology - Tập 33 Số 4 - Trang 207-213 - 2020
Fany Chuquilín-Arista, Tania Álvarez-Avellón, Manuel Menéndez‐González
Background:Identifying neuropsychiatric disorders is essential for prompt treatment to reduce morbidity. Among these disorders, anxiety and depression have been frequently associated with Parkinson disease (PD), particularly among elderly population.Objective:The objective of this study is to ...... hiện toàn bộ
MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review
Journal of Geriatric Psychiatry and Neurology - Tập 20 Số 1 - Trang 3-21 - 2007
Ludovico Minati, Marina Grisoli, Maria Grazia Bruzzone
In vivo magnetic resonance spectroscopy (MRS), functional magnetic resonance imaging (fMRI), and diffusion-tensor imaging (DTI) have recently opened new possibilities for noninvasively assessing the metabolic, functional, and connectivity correlates of aging in research and clinical settings. The purpose of this article is to provide a conceptual review intended for a multidisciplinary au...... hiện toàn bộ
CSF APPsα and Phosphorylated Tau Protein Levels in Mild Cognitive Impairment and Dementia of Alzheimer's Type
Journal of Geriatric Psychiatry and Neurology - Tập 22 Số 1 - Trang 3-9 - 2009
Andreas Fellgiebel, Elżbieta Kojro, Matthias J. Müller, Armin Scheurich, Lutz Schmidt, Falk Fahrenholz
We exploratively measured APPsα, a secreted fragment of the non-amyloidogenic cleavage of amyloid precursor protein via a-secretase, and tau protein phosphorylated at threonine 181 (ptau) in the cerebrospinal fluid of 10 patients with mild cognitive impairment, 20 patients with dementia of Alzheimer's type, and 10 controls. Cerebrospinal fluid APPsα and ptau levels were correlated with co...... hiện toàn bộ
Parental Education and Late-life Dementia in the United States
Journal of Geriatric Psychiatry and Neurology - Tập 22 Số 1 - Trang 71-80 - 2009
Mary A.M. Rogers, Brenda L. Plassman, Mohammed U. Kabeto, Gwenith G. Fisher, John J. McArdle, David J. Llewellyn, Guy G. Potter, Kenneth M. Langa
We investigated the relation between parental education and dementia in the United States. Participants in the Aging, Demographics, and Memory Study were included, with information regarding parental education obtained from the Health and Retirement Study. The odds of dementia in elderly Americans whose mothers had less then 8 years of schooling were twice (95% CI, 1.1-3.8) that of indivi...... hiện toàn bộ
Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression
Journal of Geriatric Psychiatry and Neurology - Tập 18 Số 4 - Trang 218-223 - 2005
James A. Mortimer, Amy R. Borenstein, Karen M. Gosche, David A. Snowdon
Numerous studies show that the pathology of Alzheimer’s disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer’s disease, it will be important to detect preclinical Alzheimer’s disease as early as possible for maximal treatment effect. Detection of...... hiện toàn bộ
When One Loses Empathy
Journal of Geriatric Psychiatry and Neurology - Tập 26 Số 3 - Trang 174-184 - 2013
Sharpley Hsieh, Muireann Irish, Naomi Daveson, John R. Hodges, Olivier Piguet
The effects of empathy loss in frontotemporal dementia (FTD) and Alzheimer disease (AD) on carer symptomatology were investigated. Carers of patients with 2 clinical subtypes of FTD (behavioral-variant FTD [bvFTD] = 18; semantic dementia [SD] = 14) and AD (n = 18) completed the Interpersonal Reactivity Index (IRI), a standardized questionnaire of empathy as well as a measure of perceived ...... hiện toàn bộ
Effects of Cognitive Challenge on Gait Variability in Patients with Parkinson’s Disease
Journal of Geriatric Psychiatry and Neurology - Tập 16 Số 1 - Trang 53-58 - 2003
Jeffrey M. Hausdorff, Jackov Balash, Nir Giladi
Attention plays an important role in the gait disturbances of patients with Parkinson’s disease (PD); however, the effects of “dual tasking” on fall risk and gait instability have not been well studied. The authors tested the hypothesis that gait variability increases when subjects with PD walk while performing a cognitively challenging task (CCT). Subjects with idiopathic PD walked under...... hiện toàn bộ
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