Cognitive Impairment in Parkinson Disease

Journal of Geriatric Psychiatry and Neurology - Tập 25 Số 4 - Trang 208-214 - 2012
Iracema Leroi1,2, Kathryn McDonald3,1, Hiranmayi Pantula4, Vijay Harbishettar5,6
1Institute of Brain, Behaviour and Mental Health, University of Manchester
2Manchester Mental Health and Social Care Trust, Manchester, Lancashire, UK
3Cognition and Cognitive Neuroscience, Salford Royal NHS Foundation Trust, Salford, UK
4Lytham Hospital, Old Age Psychiatry, Lancashire Care Foundation NHS Trust, Lytham, UK
5Sheffield Health and Social Care NHS Foundation Trust, Sheffield, South Yorkshire, UK
6University of Leeds, Leeds, West Yorkshire, UK

Tóm tắt

Aim: To compare quality of life, level of disability, and caregiver burden in 3 groups of people with Parkinson disease (PD): those with mild cognitive impairment (PD-MCI), those with dementia (PDD), and those with no cognitive impairment (PD-NC). Background: Although the cognitive profile of those with PD-MCI and PDD has been well described, little is known about the personal and clinical impact of cognitive impairment and its impact on caregivers. Method: Quality of life and disability were measured in 3 groups of participants with PD (PD-NC, n = 54; PD-MCI, n = 48; and PDD, n = 25). The PD-MCI group was classified using Movement Disorder Society Task Force consensus criteria. Caregivers (n = 102) in the 3 groups were assessed using the Zarit Burden Inventory. Results: Both quality of life and caregiver burden were similar in the 2 groups without dementia but were significantly different in those with PDD. In contrast, global disability was progressively greater as cognition declined across the 3 PD groups: PD-NC < PD-MCI < PDD and on the Activities of Daily Living scale a step up in impairment was seen with the presence of any cognitive impairment. Conclusions: The presence of dementia significantly increases caregiver burden and decreases quality of life. However, even mild levels of cognitive impairment increase disability and overall functional impairment progresses in tandem with cognitive decline.

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Thông tin
Thông tin xuất bản

Journal of Geriatric Psychiatry and Neurology

Tập 25 Số 4

208-214

Thông tin tác giả