Middle-Aged Children of Persons With Alzheimer’s Disease: APOE Genotypes and Cognitive Function in the Wisconsin Registry for Alzheimer’s Prevention

Journal of Geriatric Psychiatry and Neurology - Tập 18 Số 4 - Trang 245-249 - 2005
Pau Pástor1, Bruce P. Hermann2, Asenath La Rue3
1Wisconsin Alzheimer's Institute, Department of Medicine, University of Wisconsin-Madison, 53719, USA.
2Wisconsin Alzheimer’s Institute, Department of Medicine, Department of Neurology, University of Wisconsin-Madison
3Wisconsin Alzheimer’s Institute, Department of Medicine, University of Wisconsin-Madison

Tóm tắt

Adult children of persons with Alzheimer’s disease are at increased risk of developing Alzheimer’s disease because of hereditary, environmental, and health risk factors shared with affected parents. The Wisconsin Registry for Alzheimer’s Prevention (WRAP) has completed baseline assessments on 452 middle-aged persons (mean = 53 years) who have at least 1 parent with AD. Forty-five percent had 1 or more apolipoprotein (APOE) ε4 alleles. There were few significant differences between ε4 carriers and noncarriers in demographics, health, and lifestyle measures or in neuropsychological performance. The high percentage of WRAP participants who are carriers of APOE ε4 underscores their increased risk for developing Alzheimer’s disease, but the absence of differences related to APOE status and high mean scores on cognitive tests suggests that the APOE ε4 gene has yet to have a clinical impact on cognitive functioning. The WRAP cohort may be a valuable group to follow prospectively to characterize the nature of cognitive change in relation to risk factors and to identify underlying preclinical neurobiological changes.

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Thông tin xuất bản

Journal of Geriatric Psychiatry and Neurology

Tập 18 Số 4

245-249

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