Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar Disorder

Journal of Geriatric Psychiatry and Neurology - Tập 27 Số 1 - Trang 56-62 - 2014
Changtae Hahn1, Hyun Kook Lim2,3, Chang Uk Lee1
1Department of Psychiatry, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
2Department of Psychiatry, Saint Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea
3Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

Tóm tắt

In recent years, there has been an increasing interest in late-onset mental disorders. Among them, geriatric schizophrenia and bipolar disorder are significant health care risks and major causes of disability. We discussed whether late-onset schizophrenia (LOS) and late-onset bipolar (LOB) disorder can be a separate entity from early-onset schizophrenia (EOS) and early-onset bipolar (EOB) disorder in a subset of late-life schizophrenia or late-life bipolar disorder through neuroimaging studies. A literature search for imaging studies of LOS or LOB was performed in the PubMed database. Search terms used were “(imaging OR MRI OR CT OR SPECT OR DTI OR PET OR fMRI) AND (schizophrenia or bipolar disorder) AND late onset.” Articles that were published in English before October 2013 were included. There were a few neuroimaging studies assessing whether LOS and LOB had different disease-specific neural substrates compared with EOS and EOB. These researches mainly observed volumetric differences in specific brain regions, white matter hyperintensities, diffusion tensor imaging, or functional neuroimaging to explore the differences between LOS and LOB and EOS and EOB. The aim of this review was to highlight the neural substrates involved in LOS and LOB through neuroimaging studies. The exploration of neuroanatomical markers may be the key to the understanding of underlying neurobiology in LOS and LOB.

Từ khóa


Tài liệu tham khảo

10.31887/DCNS.2006.8.1/dfolsom

10.1176/appi.ajp.163.2.198

10.1176/ajp.152.3.447

10.1016/S0920-9964(97)00088-1

10.1176/jnp.9.2.251

10.1176/ajp.156.12.1958

10.1192/bjp.175.5.416

10.1017/S0033291799008685

10.1002/1099-1166(200012)15:12<1085::AID-GPS250>3.0.CO;2-X

10.1046/j.1440-1819.2000.00644.x

10.1097/00005053-200211000-00002

10.1097/00019442-200311000-00004

10.1161/01.STR.26.6.946

10.1016/j.jpsychires.2007.05.003

10.1111/j.1399-5618.2008.00621.x

10.1017/S1041610210000633

10.1016/j.pneurobio.2012.05.009

10.1192/bjp.165.4.474

Tonkonogy JM, 1999, Neuropsychiatry Neuropsychol Behav Neurol, 12, 230

10.1002/gps.1030

10.1097/00019442-200411000-00007

10.1177/0891988712436689

10.1161/01.STR.27.8.1274

10.1016/j.neurobiolaging.2013.04.023

10.1016/j.neurobiolaging.2010.07.015

10.1016/j.pscychresns.2010.11.010

10.1016/0006-3223(90)90582-M

10.1016/j.neurobiolaging.2010.02.004

10.1016/j.siny.2006.07.006

10.1016/j.neuroimage.2008.11.027

10.1016/j.biopsych.2003.07.001

10.1002/mrm.1910190222

10.1148/radiology.201.3.8939209

10.1016/j.pscychresns.2012.05.009

10.1097/YCO.0b013e32835d9e6a

10.1097/00019442-200512000-00009

10.1503/jpn.100140

10.1093/schbul/19.4.783

10.1111/j.1399-5618.2011.00927.x

10.1177/0004867412440191

Thông tin
Thông tin xuất bản

Journal of Geriatric Psychiatry and Neurology

Tập 27 Số 1

56-62

Thông tin tác giả