Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression

Journal of Geriatric Psychiatry and Neurology - Tập 18 Số 4 - Trang 218-223 - 2005
James A. Mortimer1, Amy R. Borenstein2, Karen M. Gosche3, David A. Snowdon4
1Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612-3899, USA.
2Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL
3NeuroImaging Research, Alachua, FL
4Sanders-Brown Center on Aging and Department of Neurology, University of Kentucky, Lexington, KY

Tóm tắt

Numerous studies show that the pathology of Alzheimer’s disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer’s disease, it will be important to detect preclinical Alzheimer’s disease as early as possible for maximal treatment effect. Detection of individuals by sensitive cognitive measures provides one way to identify people who are at high risk of developing clinical Alzheimer’s disease. However, it is likely that those with considerable brain or cognitive reserve will be able to mask cognitive deficits until very close to the onset of the dementia, rendering such cognitive measures insensitive. Optimum biomarkers for Alzheimer’s disease therefore need to target the severity of underlying brain pathology independently of brain reserve. Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology.

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Thông tin
Thông tin xuất bản

Journal of Geriatric Psychiatry and Neurology

Tập 18 Số 4

218-223

Thông tin tác giả