A. Zablotskaya, I. Segal, S Germane, I. Shestakova, I. Domracheva, A. Nesterova, A. Geronikaki, E. Lukevics
Trimethylsilyl ethers of various hydroxyl-containing thiazole derivatives have been synthesized. The psychotropic activity (in vivo) and the cytotoxicity (in vitro on tumor cell lines HT-1080 and MG-22A) of these ethers and of their unsilylated precursors have been studied. It was discovered that the obtained compounds possess a sedative action. A moderate cytotoxic effect was detected for piperid...... hiện toàn bộ