Basic and Clinical Pharmacology and Toxicology
SCOPUS (2004-2025)SCIE-ISI
1742-7843
1742-7835
Mỹ
Cơ quản chủ quản: Wiley-Blackwell , WILEY
Lĩnh vực:
PharmacologyMedicine (miscellaneous)Toxicology
Các bài báo tiêu biểu
Comparison of Early and Late Toxic Effects of Sulfur Mustard in Iranian Veterans
Tập 99 Số 4 - Trang 273-282 - 2006
Abstract:Sulfur mustard is an alkylating agent that reacts with ocular,
respiratory, cutaneous, and bone marrow tissues, resulting in early and late
toxic effects. We compare these effects based on the experience in Iranian
veterans exposed to the agent during the Iran‐Iraq conflict (1983–88). The first
clinical manifestations of sulfur mustard poisoning occurred in the eyes with a
sensation of gr...
How Palatable Food Disrupts Appetite Regulation
Tập 97 Số 2 - Trang 61-73 - 2005
Abstract: Appetite regulation is part of a feedback system that controls the
energy balance, involving a complex interplay of hunger and satiety signals,
produced in the hypothalamus as well as in peripheral organs. Hunger signals may
be generated in peripheral organs (e.g. ghrelin) but most of them are expressed
in the hypothalamus (neuropeptide Y, orexins, agouti‐related peptide, melanin
concent...
The Alkaline Comet Assay: Towards Validation in Biomonitoring of DNA Damaging Exposures
Tập 98 Số 4 - Trang 336-345 - 2006
Abstract: Generation of DNA damage is considered to be an important initial
event in carcinogenesis. The single cell gel electrophoresis (comet) assay is a
technically simple and fast method that detects genotoxicity in virtually any
mammalian cell type without requirement for cell culture. This review discusses
the strength of the comet assay in biomonitoring at its present state of
validation. T...
Hypotensive and Vasorelaxant Effects of Citronellol, a Monoterpene Alcohol, in Rats
Tập 106 Số 4 - Trang 331-337 - 2010
Abstract: Citronellol is an essential oil constituent from the medicinal plants
Cymbopogon citratus, Cymbopogon winterianus and Lippia alba which are thought to
possess antihypertensive properties. Citronellol‐induced cardiovascular effects
were evaluated in this study. In rats, citronellol (1–20 mg/kg, i.v.) induced
hypotension, which was not affected by pre‐treatment with atropine,
hexamethoniu...
Protective Effects of L‐Arginine against Cisplatin‐Induced Renal Oxidative Stress and Toxicity: Role of Nitric Oxide
Tập 97 Số 2 - Trang 91-97 - 2005
Abstract: Nephrotoxicity is a dose‐limiting factor in clinical use of cisplatin.
The changes in renal haemodynamics were suggested to play a role in
cisplatin‐induced nephrotoxicity. The aim of the present study was to
investigate the effect of modulation of nitric oxide on the severity of
cisplatin‐induced nephrotoxicity using an experimental rat model. A nitric oxide
precursor, L‐arginine and an...
Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer
Tập 104 Số 2 - Trang 130-137 - 2009
Abstract: The purpose of this study was to evaluate the role of sequence
variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the
pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients.
Thirty‐eight patients were treated with paclitaxel and carboplatin. The
genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB1
G2677T/A and C3435T, as well ...
Physiological Remodelling of the Maternal Uterine Circulation during Pregnancy
Tập 110 Số 1 - Trang 12-18 - 2012
Abstract: Sufficient uteroplacental blood flow is essential for normal
pregnancy outcome and is accomplished by the coordinated growth and remodelling
of the entire maternal uterine vasculature. The main focus of this MiniReview is
to provide information on upstream (pre‐placental) maternal uterine vascular
remodelling that facilitates gestational increases in uterine blood flow.
Consideration of...
Role of Platelets in Inflammation and Cancer: Novel Therapeutic Strategies
Tập 114 Số 1 - Trang 118-127 - 2014
AbstractPlatelets play a central role in inflammation through their direct
interaction with other cell types, such as leucocytes and endothelial cells, and
by the release of many factors, that is, lipids [such as thromboxane (TX)A2] and
proteins (a wide number of angiogenic and growth factors) stored in α‐granules,
and adenosine diphosphate (ADP), stored in dense granules. These platelet
actions t...
Eosinophil Apoptosis as a Therapeutic Target in Allergic Asthma
Tập 114 Số 1 - Trang 109-117 - 2014
AbstractAsthma is a chronic inflammatory disease of the airways manifesting in
many different phenotypes. Allergic asthma, comprising approximately half of
patients with asthma, is characterized by the accumulation of eosinophils into
the lungs. Eosinophils release factors that damage the surrounding cells and
participate in the maintenance and exacerbation of inflammation. In the absence
of any i...