Basic and Clinical Pharmacology and Toxicology
SCOPUS (2004-2023)SCIE-ISI
1742-7843
1742-7835
Mỹ
Cơ quản chủ quản: Wiley-Blackwell , WILEY
Lĩnh vực:
PharmacologyMedicine (miscellaneous)Toxicology
Các bài báo tiêu biểu
Comparison of Early and Late Toxic Effects of Sulfur Mustard in Iranian VeteransAbstract: Sulfur mustard is an alkylating agent that reacts with ocular, respiratory, cutaneous, and bone marrow tissues, resulting in early and late toxic effects. We compare these effects based on the experience in Iranian veterans exposed to the agent during the Iran‐Iraq conflict (1983–88). The first clinical manifestations of sulfur mustard poisoning occurred in ...
Tập 99 Số 4 - Trang 273-282 - 2006
How Palatable Food Disrupts Appetite RegulationAbstract: Appetite regulation is part of a feedback system that controls the energy balance, involving a complex interplay of hunger and satiety signals, produced in the hypothalamus as well as in peripheral organs. Hunger signals may be generated in peripheral organs (e.g. ghrelin) but most of them are expressed in the hypothalamus (neuropeptide Y, orexins, agouti‐r...
Tập 97 Số 2 - Trang 61-73 - 2005
The Alkaline Comet Assay: Towards Validation in Biomonitoring of DNA Damaging ExposuresAbstract: Generation of DNA damage is considered to be an important initial event in carcinogenesis. The single cell gel electrophoresis (comet) assay is a technically simple and fast method that detects genotoxicity in virtually any mammalian cell type without requirement for cell culture. This review discusses the strength of the comet assay in biomonitoring at its...
Tập 98 Số 4 - Trang 336-345 - 2006
Protective Effects of L‐Arginine against Cisplatin‐Induced Renal Oxidative Stress and Toxicity: Role of Nitric OxideAbstract: Nephrotoxicity is a dose‐limiting factor in clinical use of cisplatin. The changes in renal haemodynamics were suggested to play a role in cisplatin‐induced nephrotoxicity. The aim of the present study was to investigate the effect of modulation of nitric oxide on the severity of cisplatin‐induced nephrotoxicity using an experimental rat model. A nitric oxi...
Tập 97 Số 2 - Trang 91-97 - 2005
Hypotensive and Vasorelaxant Effects of Citronellol, a Monoterpene Alcohol, in RatsAbstract: Citronellol is an essential oil constituent from the medicinal plants Cymbopogon citratus , Cymbopogon winterianus and Lippia alba which are thought to possess antihypertensive properties. Citronellol‐induced cardiovascular effects were evaluated in this study. In rats, citrone...
Tập 106 Số 4 - Trang 331-337 - 2010
Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian CancerAbstract: The purpose of this study was to evaluate the role of sequence variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients. Thirty‐eight patients were treated with paclitaxel and carboplatin. The genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB...
Tập 104 Số 2 - Trang 130-137 - 2009
Physiological Remodelling of the Maternal Uterine Circulation during PregnancyAbstract: Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodelling of the entire maternal uterine vasculature. The main focus of this MiniReview is to provide information on upstream (pre‐placental) maternal uterine vascular remodelling that facilitates gestational increases in uteri...
Tập 110 Số 1 - Trang 12-18 - 2012
Role of Platelets in Inflammation and Cancer: Novel Therapeutic StrategiesAbstract Platelets play a central role in inflammation through their direct interaction with other cell types, such as leucocytes and endothelial cells, and by the release of many factors, that is, lipids [such as thromboxane (TX )A 2...
Tập 114 Số 1 - Trang 118-127 - 2014
Eosinophil Apoptosis as a Therapeutic Target in Allergic AsthmaAbstract Asthma is a chronic inflammatory disease of the airways manifesting in many different phenotypes. Allergic asthma, comprising approximately half of patients with asthma, is characterized by the accumulation of eosinophils into the lungs. Eosinophils release factors that damage the surrounding cells and participate in the maintenance and exacerbation of infl... ...
Tập 114 Số 1 - Trang 109-117 - 2014