Basic and Clinical Pharmacology and Toxicology

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Comparison of Early and Late Toxic Effects of Sulfur Mustard in Iranian Veterans
Basic and Clinical Pharmacology and Toxicology - Tập 99 Số 4 - Trang 273-282 - 2006
Mahdi Balali‐Mood, Mehrdad Hefazi
Abstract:Sulfur mustard is an alkylating agent that reacts with ocular, respiratory, cutaneous, and bone marrow tissues, resulting in early and late toxic effects. We compare these effects based on the experience in Iranian veterans exposed to the agent during the Iran‐Iraq conflict (1983–88). The first clinical manifestations of sulfur mustard poisoning occurred in ...... hiện toàn bộ
Immunological and pathological effects of electronic cigarettes
Basic and Clinical Pharmacology and Toxicology - Tập 125 Số 3 - Trang 237-252 - 2019
I‐Ling Chen, Ian Todd, Lucy Fairclough
AbstractElectronic cigarettes (E‐cigarettes) are considered a preferable alternative to conventional cigarettes due to the lack of combustion and the absence of tobacco‐specific toxicants. E‐cigarettes have rapidly gained in popularity in recent years amongst both existing smokers and previous non‐smokers. However, a growing literature demonstrates that E‐cigarette...... hiện toàn bộ
Impact of Concentrative Nucleoside Transporter 1 Gene Polymorphism on Oral Bioavailability of Mizoribine in Stable Kidney Transplant Recipients
Basic and Clinical Pharmacology and Toxicology - Tập 106 Số 4 - Trang 310-316 - 2010
Takafumi Naito, Shunsuke Tokashiki, Yasuaki Mino, Atsushi Otsuka, Seiichiro Ozono, Yoshiyuki Kagawa, Junichi Kawakami
Abstract:  Mizoribine, an immunosuppressive anti‐metabolite, is largely excreted into urine in its unchanged form, and its pharmacokinetics has been considered to be dependent on the glomerular filtration rate. However, the pharmacokinetic disposition of mizoribine has not been fully clarified. The aim of this study was to evaluate the pharmacokinetic disposition of ...... hiện toàn bộ
Role of Platelets in Inflammation and Cancer: Novel Therapeutic Strategies
Basic and Clinical Pharmacology and Toxicology - Tập 114 Số 1 - Trang 118-127 - 2014
Melania Dovizio, Sara Alberti, Paloma Guillem‐Llobat, Paola Patrignani
AbstractPlatelets play a central role in inflammation through their direct interaction with other cell types, such as leucocytes and endothelial cells, and by the release of many factors, that is, lipids [such as thromboxane (TX)A2... hiện toàn bộ
Atomoxetine Increases Histamine Release and Improves Learning Deficits in an Animal Model of Attention‐Deficit Hyperactivity Disorder: The Spontaneously Hypertensive Rat
Basic and Clinical Pharmacology and Toxicology - Tập 102 Số 6 - Trang 527-532 - 2008
Lili Liu, Jie Yang, Gefei Lei, Gongming Wang, Yuwei Wang, Ruopeng Sun
Abstract:  Substantial development in the pharmacological treatment for attention‐deficit hyperactivity disorder (ADHD) has been made recently including approval of new non‐stimulant agents targeting noradrenergic, histaminergic and dopaminergic systems. Among such, atomoxetine has been widely used, although its mechanism of action is poorly understood. It is known t...... hiện toàn bộ
Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer
Basic and Clinical Pharmacology and Toxicology - Tập 104 Số 2 - Trang 130-137 - 2009
Henrik Gréen, Peter Söderkvist, Per Rosenberg, Rajaa A. Mirghani, Per Rymark, Elisabeth Åvall Lundqvist, Curt Peterson
Abstract:  The purpose of this study was to evaluate the role of sequence variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients. Thirty‐eight patients were treated with paclitaxel and carboplatin. The genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB...... hiện toàn bộ
Predicting the Outcome of Phase III Trials using Phase II Data: A Case Study of Clinical Trial Simulation in Late Stage Drug Development
Basic and Clinical Pharmacology and Toxicology - Tập 96 Số 3 - Trang 235-241 - 2005
Filip De Ridder
Abstract: Maximizing the likelihood of success in Phase III is the ultimate goal of the use of modelling and simulation in the drug development process. The success in Phase III depends primarily on two questions: 1) Is the drug regimen actually efficacious and safe in the targeted patient population?, and 2) Will the planned Phase III clinical trial(s) be successful...... hiện toàn bộ
Triggering Mechanisms and Inflammatory Effects of Combustion Exhaust Particles with Implication for Carcinogenesis
Basic and Clinical Pharmacology and Toxicology - Tập 121 Số S3 - Trang 55-62 - 2017
Johan Øvrevik, Magne Refsnes, Marit Låg, Bendik C. Brinchmann, Per E. Schwarze, Jørn A. Holme
AbstractA number of biological responses may contribute to the carcinogenic effects of combustion‐derived particulate matter (CPM). Here, we focus on mechanisms that trigger CPM‐induced pro‐inflammatory responses. Inflammation has both genotox...... hiện toàn bộ
The Effects of l‐Carnitine Against Cyclophosphamide‐Induced Injuries in Mouse Testis
Basic and Clinical Pharmacology and Toxicology - Tập 120 Số 2 - Trang 152-158 - 2017
Yuanchao Cao, Xinsheng Wang, Shenqian Li, Hongqiang Wang, Lei Yu, Peitao Wang
AbstractIn order to explore the possibility of l‐carnitine (LC) as a protector of male fertility in chemotherapy, we observed the damage of cyclophosphamide (CTX) to Sertoli cells and the protective effect of ... hiện toàn bộ
Persistent Impairment of Testicular Histology and Sperm Motility in Adult Rats Treated with Cisplatin at Peri-Puberty
Basic and Clinical Pharmacology and Toxicology - Tập 109 Số 2 - Trang 85-96 - 2011
Ana Paula Alves Favareto, Carla Dal Bianco Fernandez, Daniela Alessandra Fossato da Silva, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
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