Basic and Clinical Pharmacology and Toxicology
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Comparison of Early and Late Toxic Effects of Sulfur Mustard in Iranian Veterans
Basic and Clinical Pharmacology and Toxicology - Tập 99 Số 4 - Trang 273-282 - 2006
Abstract:Sulfur mustard is an alkylating agent that reacts with ocular,
respiratory, cutaneous, and bone marrow tissues, resulting in early and late
toxic effects. We compare these effects based on the experience in Iranian
veterans exposed to the agent during the Iran‐Iraq conflict (1983–88). The first
clinical manifestations of sulfur mustard poisoning occurred in the eyes with a
sensation of gr...
Immunological and pathological effects of electronic cigarettes
Basic and Clinical Pharmacology and Toxicology - Tập 125 Số 3 - Trang 237-252 - 2019
AbstractElectronic cigarettes (E‐cigarettes) are considered a preferable
alternative to conventional cigarettes due to the lack of combustion and the
absence of tobacco‐specific toxicants. E‐cigarettes have rapidly gained in
popularity in recent years amongst both existing smokers and previous
non‐smokers. However, a growing literature demonstrates that E‐cigarettes are
not as safe as generally be...
Impact of Concentrative Nucleoside Transporter 1 Gene Polymorphism on Oral Bioavailability of Mizoribine in Stable Kidney Transplant Recipients
Basic and Clinical Pharmacology and Toxicology - Tập 106 Số 4 - Trang 310-316 - 2010
Abstract: Mizoribine, an immunosuppressive anti‐metabolite, is largely excreted
into urine in its unchanged form, and its pharmacokinetics has been considered
to be dependent on the glomerular filtration rate. However, the pharmacokinetic
disposition of mizoribine has not been fully clarified. The aim of this study
was to evaluate the pharmacokinetic disposition of mizoribine based on
polymorphis...
Role of Platelets in Inflammation and Cancer: Novel Therapeutic Strategies
Basic and Clinical Pharmacology and Toxicology - Tập 114 Số 1 - Trang 118-127 - 2014
AbstractPlatelets play a central role in inflammation through their direct
interaction with other cell types, such as leucocytes and endothelial cells, and
by the release of many factors, that is, lipids [such as thromboxane (TX)A2] and
proteins (a wide number of angiogenic and growth factors) stored in α‐granules,
and adenosine diphosphate (ADP), stored in dense granules. These platelet
actions t...
Atomoxetine Increases Histamine Release and Improves Learning Deficits in an Animal Model of Attention‐Deficit Hyperactivity Disorder: The Spontaneously Hypertensive Rat
Basic and Clinical Pharmacology and Toxicology - Tập 102 Số 6 - Trang 527-532 - 2008
Abstract: Substantial development in the pharmacological treatment for
attention‐deficit hyperactivity disorder (ADHD) has been made recently including
approval of new non‐stimulant agents targeting noradrenergic, histaminergic and
dopaminergic systems. Among such, atomoxetine has been widely used, although its
mechanism of action is poorly understood. It is known that central nervous
system hist...
Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer
Basic and Clinical Pharmacology and Toxicology - Tập 104 Số 2 - Trang 130-137 - 2009
Abstract: The purpose of this study was to evaluate the role of sequence
variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the
pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients.
Thirty‐eight patients were treated with paclitaxel and carboplatin. The
genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB1
G2677T/A and C3435T, as well ...
Predicting the Outcome of Phase III Trials using Phase II Data: A Case Study of Clinical Trial Simulation in Late Stage Drug Development
Basic and Clinical Pharmacology and Toxicology - Tập 96 Số 3 - Trang 235-241 - 2005
Abstract: Maximizing the likelihood of success in Phase III is the ultimate goal
of the use of modelling and simulation in the drug development process. The
success in Phase III depends primarily on two questions: 1) Is the drug regimen
actually efficacious and safe in the targeted patient population?, and 2) Will
the planned Phase III clinical trial(s) be successful in demonstrating this?
Traditi...
Triggering Mechanisms and Inflammatory Effects of Combustion Exhaust Particles with Implication for Carcinogenesis
Basic and Clinical Pharmacology and Toxicology - Tập 121 Số S3 - Trang 55-62 - 2017
AbstractA number of biological responses may contribute to the carcinogenic
effects of combustion‐derived particulate matter (CPM). Here, we focus on
mechanisms that trigger CPM‐induced pro‐inflammatory responses. Inflammation has
both genotoxic and non‐genotoxic implications and is considered to play a
central role in development of various health outcome associated with CPM
exposure, including c...
The Effects of l ‐Carnitine Against Cyclophosphamide‐Induced Injuries in Mouse Testis
Basic and Clinical Pharmacology and Toxicology - Tập 120 Số 2 - Trang 152-158 - 2017
AbstractIn order to explore the possibility of l‐carnitine (LC) as a protector
of male fertility in chemotherapy, we observed the damage of cyclophosphamide
(CTX) to Sertoli cells and the protective effect of LC on the testis Sertoli
cells from such damage in this study. Healthy adult male mice were divided into
three groups: chemotherapy group were injected intraperitoneally with the CTX;
protect...
Persistent Impairment of Testicular Histology and Sperm Motility in Adult Rats Treated with Cisplatin at Peri-Puberty
Basic and Clinical Pharmacology and Toxicology - Tập 109 Số 2 - Trang 85-96 - 2011
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