Gonadotropin-releasing hormone (GnRH) agonists are the mainstay of treatment for
recurrent and metastatic prostate cancer. GnRH agonists are also an important
part of therapy for many men with localized or locally advanced prostate cancer.
Although GnRH agonists improve survival in certain settings, they involve
adverse effects including vasomotor flushing, obesity, and osteoporosis. This
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