Current Medicinal Chemistry
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Cơ quản chủ quản: Bentham Science Publishers B.V. , BENTHAM SCIENCE PUBL LTD
Lĩnh vực:
Drug DiscoveryPharmacologyBiochemistryMolecular MedicineOrganic Chemistry
Các bài báo tiêu biểu
“Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’
Tập 10 Số 1 - Trang 51-80 - 2003
Immunomodulation and Anti-Cancer Activity of Polysaccharide-Protein Complexes
In the last three decades, numerous polysaccharides and polysaccharide-protein complexes have been isolated from mushrooms and used as a source of therapeutic agents. The most promising biopharmacological activities of these biopolymers are their immunomodulation and anti-cancer effects. They are mainly present as glucans with different types of glycosidic linkages such as (1-3), (1-6)-b-glucans and (1-3)-a-glucans, and as true herteroglycans, while others mostly bind to protein residues as polysaccharide-protein complexes. Three antitumor mushroom polysaccharides, i.e. lentinan, schizophyllan and protein-bound polysaccharide (PSK, Krestin), isolated respectively, from Lentinus edodes, Schizophyllum commune and Coriolus versicolor, have become large market items in Japan. Lentinan and schizophyllan are pure b-glucans, whereas PSK is a protein-bound b-glucan. A polysaccharide peptide (PSP), isolated from a strain of Coriolus versicolor in China, has also been widely used as an anti-cancer and immunomodulatory agent. Although the mechansim of their antitumor action is still not completely clear, these polysaccharides and polysaccharide-protein complexes are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers. Potentiation of the host defense system may result in the activation of many kinds of immune cells that are vitally important for the maintenance of homeostasis. Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors. Some interesting studies focus on investigation of the relationship between their structure and antitumor activity, elucidation of their antitumor mechanism at the molecular level, and improvement of their various biological activities by chemical modifications.
Tập 7 Số 7 - Trang 715-729 - 2000
Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism
Tập 22 Số 1 - Trang 132-149 - 2014
Converting a Peptide into a Drug: Strategies to Improve Stability and Bioavailability
Tập 9 Số 9 - Trang 963-978 - 2002
Silybin and Silymarin - New and Emerging Applications in Medicine
Tập 14 Số 3 - Trang 315-338 - 2007
Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
Tập 15 Số 23 - Trang 2321-2328 - 2008