Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Tài liệu tham khảo
Alaish, 2013, Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host, Gut Microb., 4, 292, 10.4161/gmic.24706
Allen, 2012, miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity, EMBO Mol. Med., 4, 882, 10.1002/emmm.201201228
Andrade, 2005, Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period, Gastroenterology, 129, 512, 10.1016/j.gastro.2005.05.006
Andrade, 2018, Hepatic damage by natural remedies, Semin. Liver Dis., 38, 21, 10.1055/s-0038-1623518
Aneese, 2017, Bladder urothelial carcinoma extending to rectal mucosa and presenting with rectal bleeding, World J. Gastrointest. Endosc., 9, 282, 10.4253/wjge.v9.i6.282
Ansede, 2010, An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes, Drug Metab. Dispos., 38, 276, 10.1124/dmd.109.028407
Antherieu, 2013, Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells, Hepatology (Baltimore, Md.), 57, 1518, 10.1002/hep.26160
Bachour-El Azzi, 2014, Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells, Drug Metab. Dispos., 42, 1556, 10.1124/dmd.114.058123
Baghdasaryan, 2014, Clinical application of transcriptional activators of bile salt transporters, Mol. Aspect. Med., 37, 57, 10.1016/j.mam.2013.12.001
Ballatori, 1995, Multiple canalicular transport mechanisms for glutathione S-conjugates. Transport on both ATP- and voltage-dependent carriers, J. Biol. Chem., 270, 3594, 10.1074/jbc.270.8.3594
Ballet, 2015, Preventing drug-induced liver injury: how useful are animal models?, Dig. Dis., 33, 477, 10.1159/000374093
Banales, 2006, Cholangiocyte anion exchange and biliary bicarbonate excretion, World J. Gastroenterol., 12, 3496, 10.3748/wjg.v12.i22.3496
Beilke, 2009, Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice, Drug Metab. Dispos., 37, 1035, 10.1124/dmd.108.023317
Bénichou, 1990, Criteria of drug-induced liver disorders. Report of an international consensus meeting, J. Hepatol., 11, 272, 10.1016/0168-8278(90)90124-A
Benichou, 1993, Causality assessment of adverse reactions to drugs–II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge, J. Clin. Epidemiol., 46, 1331, 10.1016/0895-4356(93)90102-7
Bertolotti, 2006, Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis, Eur. J. Clin. Invest., 36, 170, 10.1111/j.1365-2362.2006.01607.x
Bissell, 2001, Drug-induced liver injury: mechanisms and test systems, Hepatology, United States, 1009, 10.1053/jhep.2001.23505
Björnsson, 2005, Outcome and prognostic markers in severe drug-induced liver disease, Hepatology (Baltimore, Md.), 42, 481, 10.1002/hep.20800
Björnsson, 2013, Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland, Gastroenterology, 144, 1419, 10.1053/j.gastro.2013.02.006
Bjornsson, 2017, Azathioprine and 6-Mercaptopurine-induced liver injury: clinical features and outcomes, J. Clin. Gastroenterol., 51, 63, 10.1097/MCG.0000000000000568
Burkard, 2012, Generation of proliferating human hepatocytes using Upcyte(R) technology: characterisation and applications in induction and cytotoxicity assays, Xenobiotica; the fate of foreign compounds in biological systems, 42, 939, 10.3109/00498254.2012.675093
Byrne, 2009, Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing, Hepatology (Baltimore, Md.), 49, 553, 10.1002/hep.22683
Byrne, 2002, The human bile salt export pump: characterization of substrate specificity and identification of inhibitors, Gastroenterology, 123, 1649, 10.1053/gast.2002.36591
Castano, 2010, The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy, Aliment Pharmacol. Therapeut., 31, 583, 10.1111/j.1365-2036.2009.04210.x
Chalasani, 2008, Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States, Gastroenterology, 135, 10.1053/j.gastro.2008.09.011
Chang, 2004, miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1, RNA Biol., 1, 106, 10.4161/rna.1.2.1066
Church, 2018, Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: an international collaborative effort, Hepatology (Baltimore, Md.), 10.1002/hep.29802
Crocenzi, 2012, Localization status of hepatocellular transporters in cholestasis, Front. Biosci., 17, 1201, 10.2741/3981
Cuperus, 2014, The role of canalicular ABC transporters in cholestasis, Drug Metab. Dispos., 42, 546, 10.1124/dmd.113.056358
Davit-Spraul, 2012, NR1H4 analysis in patients with progressive familial intrahepatic cholestasis, drug-induced cholestasis or intrahepatic cholestasis of pregnancy unrelated to ATP8B1, ABCB11 and ABCB4 mutations, Clin Res Hepatol Gastroenterol, 36, 569, 10.1016/j.clinre.2012.08.008
Dawson, 2012, In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans, Drug Metab. Dispos., 40, 130, 10.1124/dmd.111.040758
De Bruyn, 2013, Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity, Expet Opin. Drug Metabol. Toxicol., 9, 589, 10.1517/17425255.2013.773973
de Lima Toccafondo Vieira, 2014, Hepatobiliary transporters in drug-induced cholestasis: a perspective on the current identifying tools, Expet Opin. Drug Metabol. Toxicol., 10, 581, 10.1517/17425255.2014.884069
Deng, 2016, Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency, Experimental and therapeutic medicine, 12, 3294, 10.3892/etm.2016.3752
Dietrich, 2014, Effect of drug transporter pharmacogenetics on cholestasis, Expet Opin. Drug Metabol. Toxicol., 10, 1533, 10.1517/17425255.2014.963553
Donato, 2016, Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: application to develop new predictive biomarkers for early drug development, Toxicol. Lett., 263, 58, 10.1016/j.toxlet.2016.10.008
Donato, 2015, Culture and functional characterization of human hepatoma HepG2 cells, Meth. Mol. Biol., 1250, 77, 10.1007/978-1-4939-2074-7_5
El Sherrif, 2013, Hepatotoxicity from anabolic androgenic steroids marketed as dietary supplements: contribution from ATP8B1/ABCB11 mutations?, Liver Int.: Offic. J. Int. Assoc. Study Liver, 33, 1266, 10.1111/liv.12216
Eschar, 1967, Serum levels of 5'-nucleotidase in disease, Am. J. Clin. Pathol., 47, 598, 10.1093/ajcp/47.5.598
Fader, 2017, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: alterations in biosynthesis, enterohepatic circulation, and microbial metabolism, Sci. Rep., 7, 5921, 10.1038/s41598-017-05656-8
Fickert, 2013, 331
Fontana, 2015, Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury, Am. J. Gastroenterol., 110, 1450, 10.1038/ajg.2015.283
Garzel, 2014, The role of bile salt export pump gene repression in drug-induced cholestatic liver toxicity, Drug Metab. Dispos., 42, 318, 10.1124/dmd.113.054189
Garzon, 2010, Targeting microRNAs in cancer: rationale, strategies and challenges, Nat. Rev. Drug Discov., 9, 775, 10.1038/nrd3179
Geier, 2007, Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration, Biochim. Biophys. Acta, 1773, 283, 10.1016/j.bbamcr.2006.04.014
Giannini, 2005, Liver enzyme alteration: a guide for clinicians, CMAJ (Can. Med. Assoc. J.), 172, 367, 10.1503/cmaj.1040752
Gissen, 2015, 1023
Guo, 2015, The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity, Toxicol. Mech. Meth., 25, 382, 10.3109/15376516.2015.1033074
Gyimesi, 2012, ABCMdb: a database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application, Hum. Mutat., 33, 1547, 10.1002/humu.22138
Halilbasic, 2013, Nuclear receptors as drug targets in cholestatic liver diseases, Clin. Liver Dis., 17, 161, 10.1016/j.cld.2012.12.001
Hand, 2009, Hepatic function is preserved in the absence of mature microRNAs, Hepatology (Baltimore, Md.), 49, 618, 10.1002/hep.22656
Hayashi, 2012, AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function, Hepatology (Baltimore, Md.), 55, 1889, 10.1002/hep.25591
Hayashi, 2016, Drug-induced liver injury network causality assessment: criteria and experience in the United States, Int. J. Mol. Sci., 17, 201, 10.3390/ijms17020201
He, 2015, Inhibition of MDR3 activity in human hepatocytes by drugs associated with liver injury, Chem. Res. Toxicol., 28, 1987, 10.1021/acs.chemrestox.5b00201
Hendriks, 2016
Hillman, 2016, Clinical features and outcomes of complementary and alternative medicine induced acute liver failure and injury, Am. J. Gastroenterol., 111, 958, 10.1038/ajg.2016.114
Ho, 2010, Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability, Pharmacogenetics Genom., 20, 45, 10.1097/FPC.0b013e3283349eb0
Ho, 2004, Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition, J. Biol. Chem., 279, 7213, 10.1074/jbc.M305782200
Hofmann, 2009, The enterohepatic circulation of bile acids in mammals: form and functions, Front. Biosci., 14, 2584, 10.2741/3399
Huang, 2003, Induction of bilirubin clearance by the constitutive androstane receptor (CAR), Proc. Natl. Acad. Sci. U. S. A., 100, 4156, 10.1073/pnas.0630614100
Inagaki, 2006, Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor, Proc. Natl. Acad. Sci. U. S. A., 103, 3920, 10.1073/pnas.0509592103
Kafrouni, 2007, Hepatotoxicity associated with dietary supplements containing anabolic steroids, Clin. Gastroenterol. Hepatol.: Offic. Clin. Pract. J. Am. Gastroenterol. Assoc., 5, 809, 10.1016/j.cgh.2007.02.036
Kagawa, 2015, No contribution of the ABCB11 p.444A polymorphism in Japanese patients with drug-induced cholestasis, Drug Metab. Dispos., 43, 691, 10.1124/dmd.114.061325
Kaplan, 1986, Serum alkaline phosphatase–another piece is added to the puzzle, Hepatology (Baltimore, Md.), 6, 526, 10.1002/hep.1840060334
Kienhuis, 2013, Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis, Toxicol. Lett., 221, 225, 10.1016/j.toxlet.2013.06.236
Kim, 2017, A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models, Hepatology (Baltimore, Md.), 66, 1662, 10.1002/hep.29324
Kis, 2009, Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors, Drug Metab. Dispos., 37, 1878, 10.1124/dmd.108.024778
Kulkarni, 2016, Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis, Hepatology (Baltimore, Md.), 64, 2151, 10.1002/hep.28826
Kullak-Ublick, 2017, Drug-induced liver injury: recent advances in diagnosis and risk assessment, Gut, 66, 1154, 10.1136/gutjnl-2016-313369
Lang, 2007, Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury, Pharmacogenetics Genom., 17, 47, 10.1097/01.fpc.0000230418.28091.76
LaRusso, 2017, Role of the intestinal microbiome in cholestatic liver disease, Dig. Dis., 35, 166, 10.1159/000450906
Le Vee, 2009, Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6, Drug Metab. Dispos., 37, 685, 10.1124/dmd.108.023630
Le Vee, 2013, Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells, Toxicol. Vitro, 27, 1979, 10.1016/j.tiv.2013.07.003
Levy, 2015, Long-term culture and expansion of primary human hepatocytes, Nat. Biotechnol., 33, 1264, 10.1038/nbt.3377
Lewis, 1999, Drug- and chemical-induced cholestasis, Clin. Liver Dis., 3, 433, 10.1016/S1089-3261(05)70079-9
Li, 2015, Bile acid metabolism and signaling in cholestasis, inflammation and cancer, Adv. Pharmacol., 74, 263, 10.1016/bs.apha.2015.04.003
Liebe, 2016, Heterozygous inactivation of the nuclear receptor PXR/NR1I2 in a patient with anabolic steroid-induced intrahepatic cholestasis, Hepat. Mon., 16, 10.5812/hepatmon.35953
Lucena, 2008, Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury, Hepatology (Baltimore, Md.), 48, 588, 10.1002/hep.22370
Mahdi, 2016, Role of multidrug resistance protein 3 in antifungal-induced cholestasis, Mol. Pharmacol., 90, 23, 10.1124/mol.116.103390
Maier, 2018, Extensive impact of non-antibiotic drugs on human gut bacteria, Nature, 555, 623, 10.1038/nature25979
Makishima, 1999, Identification of a nuclear receptor for bile acids, Science, 284, 1362, 10.1126/science.284.5418.1362
Mariotti, 2018, Animal models of biliary injury and altered bile acid metabolism, Biochim. Biophys. Acta, 1864, 1254, 10.1016/j.bbadis.2017.06.027
Mattner, 2016, Impact of microbes on the pathogenesis of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), Int. J. Mol. Sci., 17, 10.3390/ijms17111864
Meier, 2006, Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver, Hepatology (Baltimore, Md.), 44, 62, 10.1002/hep.21214
Meier, 2008, Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump, World J. Gastroenterol., 14, 38, 10.3748/wjg.14.38
Miszczuk, 2018, Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver, Biochim. Biophys. Acta, 1864, 1072, 10.1016/j.bbadis.2018.01.015
Mita, 2006, Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep, Am. J. Physiol. Gastrointest. Liver Physiol., 290, G550, 10.1152/ajpgi.00364.2005
Miyake, 2000, Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase, J. Biol. Chem., 275, 21805, 10.1074/jbc.C000275200
Miyake, 2013, Role of gut microbiota in liver diseases, Hepatol. Res. : the official journal of the Japan Society of Hepatology, 43, 139, 10.1111/j.1872-034X.2012.01088.x
Mohi-ud-din, 2004, Drug- and chemical-induced cholestasis, Clin. Liver Dis., 8, 95, 10.1016/S1089-3261(03)00124-7
Morgan, 2010, Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development, Toxicol. Sci., 118, 485, 10.1093/toxsci/kfq269
Morgan, 2013, A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development, Toxicol. Sci., 136, 216, 10.1093/toxsci/kft176
Norris, 2008, Drug-induced liver injury in 2007, Curr. Opin. Gastroenterol., 24, 287, 10.1097/MOG.0b013e3282f9764b
Nozawa, 2005, Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms, Drug Metab. Dispos., 33, 434, 10.1124/dmd.104.001909
Pauli-Magnus, 2006, Hepatobiliary transporters and drug-induced cholestasis, Hepatology (Baltimore, Md.), 44, 778, 10.1002/hep.21359
Pedersen, 2013, Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11), Toxicol. Sci., 136, 328, 10.1093/toxsci/kft197
Qin, 2014, Alterations of the human gut microbiome in liver cirrhosis, Nature, 513, 59, 10.1038/nature13568
Qiu, 2016, Disruption of BSEP function in HepaRG cells alters bile acid disposition and is a susceptive factor to drug-induced cholestatic injury, Mol. Pharm., 13, 1206, 10.1021/acs.molpharmaceut.5b00659
Ramaiahgari, 2017, Three-dimensional (3D) HepaRG spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity screening, Toxicol. Sci., 160, 189, 10.1093/toxsci/kfx194
Renga, 2013, The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation, PLoS One, 8, 10.1371/journal.pone.0054472
Renga, 2011, Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter, Biochim. Biophys. Acta, 1809, 157, 10.1016/j.bbagrm.2011.01.008
Roma, 2011, Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications, Clinical science (London, England: 1979), 121, 523, 10.1042/CS20110184
Roth, 2012, OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies, Br. J. Pharmacol., 165, 1260, 10.1111/j.1476-5381.2011.01724.x
Schaefer, 2016, Upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds, Drug Metab. Dispos., 44, 435, 10.1124/dmd.115.067348
Schaefer, 2018, Quantitative expression of hepatobiliary transporters and functional uptake of substrates in hepatic 2D sandwich-cultures: a comparative evaluation of upcyte and primary human hepatocytes, Drug Metab. Dispos., 46, 166, 10.1124/dmd.117.078238
Sharanek, 2017, Progressive and preferential cellular accumulation of hydrophobic bile acids induced by cholestatic drugs is associated with inhibition of their amidation and sulfation, Drug Metab. Dispos., 45, 1292, 10.1124/dmd.117.077420
Shoda, 2004, Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4, J. Lipid Res., 45, 1813, 10.1194/jlr.M400132-JLR200
Song, 2010, A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes, J. Lipid Res., 51, 2223, 10.1194/jlr.M004531
Stedman, 2005, Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury, Proc. Natl. Acad. Sci. U. S. A., 102, 2063, 10.1073/pnas.0409794102
Sticova, 2013, New insights in bilirubin metabolism and their clinical implications, World J. Gastroenterol., 19, 6398, 10.3748/wjg.v19.i38.6398
Stieger, 2011, Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis, Expet Opin. Drug Metabol. Toxicol., 7, 411, 10.1517/17425255.2011.557067
Stieger, 1992, ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles, Biochem. J., 284, 67, 10.1042/bj2840067
Stojakovic, 2007, Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid, Hepatology (Baltimore, Md.), 46, 776, 10.1002/hep.21741
Sturm, 2005, Candesartan Cilexetil (Atacand) induced prolonged severe cholestasis improved by extracorporeal albumin dialysis, Gastroenterol Clin Biol., France, 1299, 10.1016/S0399-8320(05)82229-8
Susukida, 2015, Prediction of the clinical risk of drug-induced cholestatic liver injury using an in vitro sandwich cultured hepatocyte assay, Drug Metab. Dispos., 43, 1760, 10.1124/dmd.115.065425
Swann, 2011, Systemic gut microbial modulation of bile acid metabolism in host tissue compartments, Proc. Natl. Acad. Sci. U. S. A., 108, 4523, 10.1073/pnas.1006734107
Swift, 2010, Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity, Drug Metab. Rev., 42, 446, 10.3109/03602530903491881
Tirona, 2001, Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans, J. Biol. Chem., 276, 35669, 10.1074/jbc.M103792200
Tolosa, 2016, Human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing, Toxicol. Sci., 152, 214, 10.1093/toxsci/kfw078
Trauner, 2003, Bile salt transporters: molecular characterization, function, and regulation, Physiol. Rev., 83, 633, 10.1152/physrev.00027.2002
Trottier, 2006, Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors, Mol. Pharm., 3, 212, 10.1021/mp060020t
Ulzurrun, 2013, Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury, Liver Int.: Offic. J. Int. Assoc. Study Liver, 33, 1378, 10.1111/liv.12193
Van de Steeg, 2012, Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver, J. Clin. Invest., 122, 519, 10.1172/JCI59526
Van den Hof, 2017, Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis, Toxicol. Vitro, 44, 322, 10.1016/j.tiv.2017.07.024
Van den Hof, 2014, Classification of hepatotoxicants using HepG2 cells: a proof of principle study, Chem. Res. Toxicol., 27, 433, 10.1021/tx4004165
Van Summeren, 2011, Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells, Toxicol. Sci., 120, 109, 10.1093/toxsci/kfq380
Van Summeren, 2013, Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, Amiodarone, and Cyclosporin A as Model Compounds: An Omics-Guided Approach, OMICS, 71
Vavassori, 2009, The bile acid receptor FXR is a modulator of intestinal innate immunity, J. Immunol., 183, 6251, 10.4049/jimmunol.0803978
Vaz, 2015, Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype, Hepatology (Baltimore, Md.), 61, 260, 10.1002/hep.27240
Vinken, 2018, In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist, Arch. Toxicol., 92, 1909, 10.1007/s00204-018-2201-4
Wagner, 2005, CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice, Hepatology (Baltimore, Md.), 42, 420, 10.1002/hep.20784
Wang, 2004, The maintenance and generation of membrane polarity in hepatocytes, Hepatology (Baltimore, Md.), 39, 892, 10.1002/hep.20039
Wang, 2002, The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II, J. Clin. Invest., 110, 965, 10.1172/JCI0215968
Wang, 2014, Resveratrol effectively attenuates alpha-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms, Acta Pharmacol. Sin., 35, 1527, 10.1038/aps.2014.119
Wolters, 2016, Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine a-induced cholestasis, Chem. Res. Toxicol., 29, 2164, 10.1021/acs.chemrestox.6b00337
Woolbright, 2016, Bile acid-induced toxicity in HepaRG cells recapitulates the response in primary human hepatocytes, Basic Clin. Pharmacol. Toxicol., 118, 160, 10.1111/bcpt.12449
Yamaura, 2012, Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis, PLoS One, 7, 10.1371/journal.pone.0030250
Yang, 2001, Nifedipine modulation of biliary GSH and GSSG/ conjugate efflux in normal and regenerating rat liver, Am. J. Physiol. Gastrointest. Liver Physiol., 281, G85, 10.1152/ajpgi.2001.281.1.G85
Yip, 2018, The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat, Hepatology, 67, 282, 10.1002/hep.29327
Yoshikado, 2011, Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4, Mol. Pharmacol., 79, 241, 10.1124/mol.110.067256
Zeigerer, 2017, Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance, Exp. Cell Res., 350, 242, 10.1016/j.yexcr.2016.11.027
Zhang, 2009, Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists, Biochem. Biophys. Res. Commun., 379, 476, 10.1016/j.bbrc.2008.12.117
Zollner, 2014, Alterations of canalicular ATP-binding cassette transporter expression in drug-induced liver injury, Digestion, 90, 81, 10.1159/000365003