The current state of serum biomarkers of hepatotoxicity

Amacher, 1998, Serum transaminase elevations as indicators of hepatic injury following the administration of drugs, Regul. Toxicol. Pharmacol., 27, 119, 10.1006/rtph.1998.1201 Amacher, 2002, A toxicologist's guide to biomarkers of hepatic response, Hum. Exp. Toxicol., 21, 253, 10.1191/0960327102ht247oa Amacher, 2005, Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy, Clin. Chem., 51, 1796, 10.1373/clinchem.2005.049908 Antoine, 1989, Electrophoretic mobility of gamma-glutamyltransferase in rat liver subcellular fractions. Evidence for structure difference from the kidney enzyme, Biochem. J., 262, 535, 10.1042/bj2620535 Ashamiss, 2004, Clinical significance of arginase after liver transplantation, Ann. Transplant., 9, 58 Beckett, 1989, Plasma glutathione-S-transferase and F protein are more sensitive than alanine aminotransferase as markers of paracetamol (acetaminophen)-induced liver damage, Clin. Chem., 35, 2186, 10.1093/clinchem/35.11.2186 Bergmeyer, 1974, Malate Dehydrogenase, vol. 2, 613 Boone, 2005, Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies, Vet. Clin. Pathol., 34, 182, 10.1111/j.1939-165X.2005.tb00041.x Brophy, 2001, Polymorphisms in the human paraoxonase (PON1) promoter, Pharmacogenetics, 11, 77, 10.1097/00008571-200102000-00009 Burhop, 2004, Review of hemoglobin-induced myocardial lesions, Artif. Cells Blood Substit. Immobil. Biotechnol., 32, 353, 10.1081/BIO-200027429 Callaghan, 1994, A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients, Acta Neurol. Scand., 89, 237, 10.1111/j.1600-0404.1994.tb01673.x Carakostas, 1986, Evaluating toxin-induced hepatic injury in rats by laboratory results and discriminant analysis, Vet. Pathol., 23, 264, 10.1177/030098588602300306 Chang, 1992, One-year dietary toxicity study with methidathion in beagle dogs, Fundam. Appl. Toxicol., 19, 307, 10.1016/0272-0590(92)90165-E Coles, 2001, Effect of polymorphism in the human glutathione-S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression, Pharmacogenetics, 11, 663, 10.1097/00008571-200111000-00004 Costa, 2003, Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism, Annu. Rev. Med., 54, 371, 10.1146/annurev.med.54.101601.152421 Costa, 2003, Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates, J. Toxicol. Clin. Toxicol., 41, 37, 10.1081/CLT-120018269 Costa, 2005, Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity, Clin. Chim. Acta, 352, 37, 10.1016/j.cccn.2004.09.019 Coles, 2005, Human alpha class glutathione-S-transferases: genetic polymorphism, expression, and susceptibility to disease, Methods Enzymol., 401, 9, 10.1016/S0076-6879(05)01002-5 Csanaky, 2005, Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats, Toxicology, 207, 91, 10.1016/j.tox.2004.09.002 Davies, 1996, The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin, Nat. Genet., 14, 334, 10.1038/ng1196-334 Dwenger, 1983, Purine-nucleoside phosphorylase, vol. 3, 382 Dufour, 2001, Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring, Clin. Chem., 47, 1133 Feingold, 1998, Paraoxonase activity in the serum and hepatic mRNA levels decrease during the acute phase response, Atherosclerosis, 139, 307, 10.1016/S0021-9150(98)00084-7 Ferré, 2002, Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage, Clin. Chem., 48, 261, 10.1093/clinchem/48.2.261 Foster, 1989, Serum F protein: a new sensitive and specific test of hepatocellular damage, Clin. Chim. Acta, 184, 85, 10.1016/0009-8981(89)90259-3 Fravi, 1968, Induction by allogeneic extracts of liver-specific precipitating autoantibodies in the mouse, Nature, 218, 141, 10.1038/218141a0 Fukuda, 2004, Kupffer cell depletion attenuates superoxide anion release into the hepatic sinusoids after lipopolysaccharide treatment, J. Gastroenterol. Hepatol., 19, 1155, 10.1111/j.1440-1746.2004.03408.x Furlong, 2002, Pharmacogenomic considerations of the paraoxonase polymorphisms, Pharmacogenomics, 3, 341, 10.1517/14622416.3.3.341 Giffen, 2002, Alpha-glutathione-S-transferase in the assessment of hepatotoxicity–its diagnostic utility in comparison with other recognized markers in the Wistar Han rat, Toxicol. Pathol., 30, 365, 10.1080/01926230252929945 Giffen, 2003, Markers of experimental acute inflammation in the Wistar Han rat with particular reference to haptoglobin and C-reactive protein, Arch. Toxicol., 77, 392, 10.1007/s00204-003-0458-7 Geuken, 2004, Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation, J. Hepatol., 41, 1017, 10.1016/j.jhep.2004.08.023 Goldberg, 1980, Structural, functional, and clinical aspects of gamma-glutamyltransferase, CRC Crit. Rev. Clin. Lab. Sci., 12, 1, 10.3109/10408368009108725 Heisterkamp, 1991, Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase, Proc. Natl. Acad. Sci. U.S.A., 88, 6303, 10.1073/pnas.88.14.6303 Horney, 1993, Stability of sorbitol dehydrogenase activity in bovine and equine sera, Vet. Clin. Pathol., 22, 5, 10.1111/j.1939-165X.1993.tb00869.x Jadhao, 2004, Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver, Hepatology, 39, 1297, 10.1002/hep.20182 Josse, 1999, Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis, Chem. Biol. Interact., 119–120, 71, 10.1016/S0009-2797(99)00015-0 Kawai, 1990, Clinical usefulness of malate dehydrogenase and its mitochondrial isoenzyme in comparison with aspartate aminotransferase and its mitochondrial isoenzyme in sera of patients with liver disease, Clin. Biochem., 23, 327, 10.1016/0009-9120(90)80064-P Khayrollah, 1982, Serum alcohol dehydrogenase activity in liver diseases, Ann. Clin. Biochem., 19, 35, 10.1177/000456328201900108 Kilic, 2005, Serum arylesterase and paraoxonase activity in patient with chronic hepatitis, World J. Gastroenterol., 11, 7351, 10.3748/wjg.v11.i46.7351 Korsrud, 1972, Sensitivity of several serum enzymes in detecting carbon tetrachloride-induced liver damage in rats, Toxicol. Appl. Pharmacol., 22, 474, 10.1016/0041-008X(72)90255-4 Leonard, 1984, Serum gamma glutamyltransferase as a specific indicator of bile duct lesions in the rat liver, Am. J. Pathol., 116, 262 Lindblom, P., Rafter, I., Copley, C., Andersson, U., Hedberg, J.J., Berg, A.L., Samuelsson, A., Hellmold, H., Cotgreave, I., Glinghammar, B., 2007. Isoforms of alanine aminotransferases in human tissues and serum—differential tissue expression using novel antibodies. Arch. Biochem. Biophys. [Epub ahead of print]. Meneses-Lorente, 2004, A proteomic investigation of drug-induced steatosis in rat liver, Chem. Res. Toxicol., 17, 605, 10.1021/tx034203n Misra, 1991, Serum malate dehydrogenase (MDH) in portal hypertension–its value as a diagnostic and prognostic indicator, Indian J. Med. Sci., 45, 31 Mochida, 1999, Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats, Hepatology, 29, 1532, 10.1002/hep.510290533 Mueller, 1983, Isoenzymes of alkaline phosphatase in infantile hypophosphatasia, J. Lab. Clin. Med., 102, 24 Murayama, 2007, Advantage of serum type-I arginase and ornithine carbamoyltransferase in the evaluation of acute and chronic liver damage induced by thioacetamide in rats, Clin. Chim. Acta, 375, 63, 10.1016/j.cca.2006.06.018 Nathwani, 2005, Serum alanine aminotransferase in skeletal muscle diseases, Hepatology, 41, 380, 10.1002/hep.20548 Neve, 2003, Tissue distribution, intracellular localization and proteolytic processing of rat 4-hydroxyphenylpyruvate dioxygenase, Cell. Biol. Int., 27, 611, 10.1016/S1065-6995(03)00117-3 Ng, 2006, Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lowere apolipoprotein-B-containing lipoproteins, J. Biol. Chem., 281, 29491, 10.1074/jbc.M605379200 Nishio, 2000, Diagnosis and treatment of primary biliary cirrhosis, Med. Sci. Monit., 6, 181 O’Brien, 2002, Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats, Lab. Anim., 36, 313, 10.1258/002367702320162414 Ohuchi, 1995, Endogenous ET-1 contributes to liver injury induced by galactosamine and endotoxin in isolated perfused rat liver, Am. J. Physiol., 268, G997 Olson, 2000, Concordance of the toxicity of pharmaceuticals in humans and in animals, Regul. Toxicol. Pharmacol., 32, 56, 10.1006/rtph.2000.1399 Oliveira, 1986, Bulk immunopurification and development of a radioimmunoassay for human and murine F liver protein, J. Immunol. Methods, 91, 99, 10.1016/0022-1759(86)90107-9 Oliveira, 1987, The phylogenetic distribution of the liver protein F antigen, Comp. Biochem. Physiol., 87B, 87 Ramaiah, 2007, A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters, Food Chem. Toxicol., 45, 1551, 10.1016/j.fct.2007.06.007 Richter, 1999, Determination of paraoxonase (PON1) status requires more than genotyping, Pharmacogenetics, 9, 745, 10.1097/00008571-199912000-00009 Rodrigo, 2001, Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver, kidney, lung and brain tissue. Implications for its physiological role, Chem. Biol. Interact., 137, 123, 10.1016/S0009-2797(01)00225-3 Rozek, 2005, The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status, J. Lipid Res., 46, 1888, 10.1194/jlr.M400489-JLR200 Rozenberg, 2005, Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice, Atherosclerosis, 181, 9, 10.1016/j.atherosclerosis.2004.12.030 Sastre, 1991, Significance of gamma-glutamyltranspeptidase in exocrine pancreatic amino acid transport, Biochim. Biophys. Acta, 1065, 213, 10.1016/0005-2736(91)90232-W Seefeld, 1979, Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on indocyanine green blood clearance in rhesus monkeys, Toxicology, 14, 263, 10.1016/0300-483X(79)90008-8 Sheehan, 1979, Predictive values of various liver function tests with respect to the diagnosis of liver disease, Clin. Biochem., 12, 262, 10.1016/S0009-9120(79)80122-8 Stempfel, 1955, Concentration of bilirubin in cerebrospinal fluid in hemolytic disease of the newborn, Pediatrics, 16, 184, 10.1542/peds.16.2.184 Tong, 2005, Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes, Toxicol. Sci., 86, 436, 10.1093/toxsci/kfi185 Wright, 2007, Risperidone- and quetiapine-induced cholestasis, Ann. Pharmacother., 41, 1518, 10.1345/aph.1K145 Xu, 2004, Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential, Chem. Biol. Interact., 150, 115, 10.1016/j.cbi.2004.09.011 Yang, 2002, cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase, Genomics, 79, 445, 10.1006/geno.2002.6722 Zelewski, 1991, Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme, Eur. J. Biochem., 201, 339, 10.1111/j.1432-1033.1991.tb16291.x Zieve, 1985, Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations, J. Lab. Clin. Med., 105, 619 Zollner, 2006, Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations, Mol. Pharm., 3, 231, 10.1021/mp060010s