Disruption of Dicer1 Induces Dysregulated Fetal Gene Expression and Promotes Hepatocarcinogenesis

Gastroenterology - Tập 136 - Trang 2304-2315.e4 - 2009
Shigeki Sekine1, Reiko Ogawa2, Rie Ito2, Nobuyoshi Hiraoka2, Michael T. McManus1, Yae Kanai2, Matthias Hebrok1
1Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California
2Pathology Division, National Cancer Center Research Institute, Tokyo, Japan

Tài liệu tham khảo

Harfe, 2005, The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb, Proc Natl Acad Sci U S A, 102, 10898, 10.1073/pnas.0504834102 Murchison, 2005, Characterization of Dicer-deficient murine embryonic stem cells, Proc Natl Acad Sci U S A, 102, 12135, 10.1073/pnas.0505479102 Kanellopoulou, 2005, Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing, Genes Dev, 19, 489, 10.1101/gad.1248505 Esau, 2006, miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting, Cell Metab, 3, 87, 10.1016/j.cmet.2006.01.005 Krutzfeldt, 2005, Silencing of microRNAs in vivo with ‘antagomirs’, Nature, 438, 685, 10.1038/nature04303 Grimm, 2006, Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways, Nature, 441, 537, 10.1038/nature04791 Ladeiro, 2008, MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations, Hepatology, 47, 1955, 10.1002/hep.22256 Gramantieri, 2007, Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma, Cancer Res, 67, 6092, 10.1158/0008-5472.CAN-06-4607 Calabrese, 2007, RNA sequence analysis defines Dicer's role in mouse embryonic stem cells, Proc Natl Acad Sci U S A, 104, 18097, 10.1073/pnas.0709193104 Postic, 1999, Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase, J Biol Chem, 274, 305, 10.1074/jbc.274.1.305 Sekine, 2007, Liver specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy, Hepatology, 45, 361, 10.1002/hep.21523 Obernosterer, 2007, Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections, Nat Protoc, 2, 1508, 10.1038/nprot.2007.153 Sharov, 2005, A web-based tool for principal component and significance analysis of microarray data, Bioinformatics, 21, 2548, 10.1093/bioinformatics/bti343 Dennis, 2003, DAVID: Database for Annotation, Visualization, and Integrated Discovery, Genome Biol, 4, P3, 10.1186/gb-2003-4-5-p3 Barad, 2004, MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues, Genome Res, 14, 2486, 10.1101/gr.2845604 Clotman, 2002, The onecut transcription factor HNF6 is required for normal development of the biliary tract, Development, 129, 1819, 10.1242/dev.129.8.1819 Sandgren, 1991, Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene, Cell, 66, 245, 10.1016/0092-8674(91)90615-6 Overturf, 1996, Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I, Nat Genet, 12, 266, 10.1038/ng0396-266 Grompe, 1999, Principles of therapeutic liver repopulation, Semin Liver Dis, 19, 7, 10.1055/s-2007-1007093 Lagos-Quintana, 2002, Identification of tissue-specific microRNAs from mouse, Curr Biol, 12, 735, 10.1016/S0960-9822(02)00809-6 Lu, 2005, MicroRNA expression profiles classify human cancers, Nature, 435, 834, 10.1038/nature03702 Calin, 2006, MicroRNA signatures in human cancers, Nat Rev Cancer, 6, 857, 10.1038/nrc1997 Kumar, 2007, Impaired microRNA processing enhances cellular transformation and tumorigenesis, Nat Genet, 39, 673, 10.1038/ng2003 Uriel, 1976, Cancer, retrodifferentiation, and the myth of Faust, Cancer Res, 36, 4269 Alexander, 1972, Foetal “antigens” in cancer, Nature, 235, 137, 10.1038/235137a0 Taketa, 1990, Alpha-fetoprotein: reevaluation in hepatology, Hepatology, 12, 1420, 10.1002/hep.1840120625 Johnson, 2001, The role of serum alpha-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma, Clin Liver Dis, 5, 145, 10.1016/S1089-3261(05)70158-6 Zhu, 2001, Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders, Gut, 48, 558, 10.1136/gut.48.4.558 Capurro, 2003, Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma, Gastroenterology, 125, 89, 10.1016/S0016-5085(03)00689-9 Yao, 2003, A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma, J Clin Invest, 111, 265, 10.1172/JCI200315109 Huang, 2007, Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma, Carcinogenesis, 28, 1094, 10.1093/carcin/bgl215 Capurro, 2005, Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling, Cancer Res, 65, 6245, 10.1158/0008-5472.CAN-04-4244 Damiani, 2008, Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina, J Neurosci, 28, 4878, 10.1523/JNEUROSCI.0828-08.2008 Wang, 2007, DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal, Nat Genet, 39, 380, 10.1038/ng1969 Koralov, 2008, Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage, Cell, 132, 860, 10.1016/j.cell.2008.02.020 Evan, 1992, Induction of apoptosis in fibroblasts by c-myc protein, Cell, 69, 119, 10.1016/0092-8674(92)90123-T Pelengaris, 2002, Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression, Cell, 109, 321, 10.1016/S0092-8674(02)00738-9 Strasser, 1990, Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2, Nature, 348, 331, 10.1038/348331a0 Jacobs, 1999, Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF, Genes Dev, 13, 2678, 10.1101/gad.13.20.2678 Nakanishi, 2005, Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma, Cancer, 103, 307, 10.1002/cncr.20774 Schmidt, 1997, Increased MAPK expression and activity in primary human hepatocellular carcinoma, Biochem Biophys Res Commun, 236, 54, 10.1006/bbrc.1997.6840