Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats

Biomedicine & Pharmacotherapy - Tập 89 - Trang 61-68 - 2017
Yanling Zhao1, Xuan He2, Xiao Ma3, Jianxia Wen1,3, Pengyan Li1, Jiabo Wang1, Ruisheng Li1, Yun Zhu1, Shizhang Wei1, Haotian Li1, Xuelin Zhou1, Kun Li1, Honghong Liu1, Xiaohe Xiao1
1Department of Pharmacy, 302 Hospital of People’s Liberation Army, Beijing, People’s Republic of China
2Department of Pharmacy, Xindu District Shibantan Public Hospital, Chengdu, People’s Republic of China
3Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China

Tài liệu tham khảo

Beuers, 2015, New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond, J. Hepatol., 62, S25, 10.1016/j.jhep.2015.02.023 Allen, 2011, Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis, Am. J. Pathol., 178, 175, 10.1016/j.ajpath.2010.11.026 Weerachayaphorn, 2014, Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice, J. Hepatol., 60, 160, 10.1016/j.jhep.2013.08.015 Donepudi, 2012, The traditional ayurvedic medicine Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis, Liver Int., 32, 560, 10.1111/j.1478-3231.2011.02724.x Woolbright, 2013, Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice, Toxicol. Appl. Pharmacol., 273, 524, 10.1016/j.taap.2013.09.023 Chen, 2012, Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats, J. Nutr. Biochem., 23, 252, 10.1016/j.jnutbio.2010.11.022 Ou, 2016, Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions, Pediatr. Res., 79, 589, 10.1038/pr.2015.252 Yan, 2015, Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats, J. Ethnopharmacol., 172, 202, 10.1016/j.jep.2015.06.044 Ma, 2015, Paeonia lactiflora Pall protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway, Drug. Des. Devel. Ther., 9, 5061 Ma, 2014, Large dosage of chishao in formulae for cholestatic hepatitis: a systematic review and meta-analysis. Evid. Based, Complement. Alternat. Med., 2014, 328152 Sun, 2012, A standardized extract from Paeonia lactiflora and Astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats, Int. J. Mol. Med., 29, 491 Gao, 2011, Qi-Shao-Shuang-Gan, a combination of Astragalus membranaceus saponins with Paeonia lactiflora glycosides, ameliorates polymicrobial sepsis induced by cecal ligation and puncture in mice, Inflammation, 34, 10, 10.1007/s10753-010-9202-7 Zhao, 2015, Large dose means significant effect–dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats, BMC Complement. Altern. Med., 15, 104, 10.1186/s12906-015-0637-0 Zhao, 2013, Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats, Food. Chem. Toxicol., 58, 242, 10.1016/j.fct.2013.04.030 Jiang, 2012, Comparative pharmacokinetic study of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra in normal rats and the acute cholestasis hepatitis rats, Fitoterapia, 83, 415, 10.1016/j.fitote.2011.12.009 Chen, 2015, Paeoniflorin ameliorates acute myocardial infarction of rats by inhibiting inflammation and inducible nitric oxide synthase signaling pathways, Mol. Med. Rep., 12, 3937, 10.3892/mmr.2015.3870 Jia, 2016, Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2, Exp. Ther. Med., 11, 655, 10.3892/etm.2015.2908 Ni, 2015, Protective effects of paeoniflorin on alveolar bone resorption and soft-tissue breakdown in experimental periodontitis, J. Periodontal. Res., 51, 257, 10.1111/jre.12305 Chen, 2015, Paeoniflorin protects against concanavalin A-induced hepatitis in mice, Int. Immunopharmacol., 24, 42, 10.1016/j.intimp.2014.11.006 Fardel, 2009, Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines, Expert. Opin. Drug. Metab. Toxicol., 5, 1469, 10.1517/17425250903304056 Geier, 2005, Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver, Am. J. Physiol. Gastrointest. Liver Physiol., 289, G831, 10.1152/ajpgi.00307.2004 Miyake, 2000, Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase, J. Biol. Chem., 275, 21805, 10.1074/jbc.C000275200 Kossor, 1993, Temporal relationship of changes in hepatobiliary function and morphology in rats following alpha-naphthylisothiocyanate (ANIT) administration, Toxicol. Appl. Pharmacol., 119, 108, 10.1006/taap.1993.1049 Carpenter-Deyo, 1991, Involvement of glutathione in 1-naphthylisothiocyanate (ANIT) metabolism and toxicity to isolated hepatocytes, Biochem. Pharmacol., 42, 2171, 10.1016/0006-2952(91)90353-7 Chen, 2016, Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2, J. Ethnopharmacol., 179, 197, 10.1016/j.jep.2015.12.033 Wu, 2013, Protective effect of Calculus Bovis Sativus on intrahepatic cholestasis in rats induced by α-naphthylisothiocyanate, Am. J. Chin. Med., 41, 1393, 10.1142/S0192415X13500936 Yang, 2012, Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids, J. Ethnopharmacol., 144, 599, 10.1016/j.jep.2012.09.049 Chen, 2015, Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats, Phytother. Res., 29, 1768, 10.1002/ptr.5431 Ma, 2016, Metabolomics coupled with multivariate data and pathway analysis on potential biomarkers in cholestasis and intervention effect of paeonia lactiflora pall, Front. Pharmacol., 7, 14, 10.3389/fphar.2016.00014 Meng, 2015, Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis, Toxicol. Appl. Pharmacol., 283, 178, 10.1016/j.taap.2015.01.020 Lam, 2010, The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease, Semin. Liver Dis., 30, 125, 10.1055/s-0030-1253222 Chai, 2015, Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis, J. Hepatol., 63, 1440, 10.1016/j.jhep.2015.07.016 Wang, 2014, Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms, Acta. Pharmacol. Sin., 35, 1527, 10.1038/aps.2014.119 Jin, 2013, Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis, BMC. Gastroenterol., 13, 79, 10.1186/1471-230X-13-79 Lickteig, 2007, Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis, Drug. Metab. Dispos., 35, 402, 10.1124/dmd.106.012138 Simpson, 1997, Cytokines and the liver, J. Hepatol., 27, 1120, 10.1016/S0168-8278(97)80160-2