miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

Journal of Hepatology - Tập 58 - Trang 119-125 - 2013
Rui E. Castro1,2, Duarte M.S. Ferreira1, Marta B. Afonso1, Pedro M. Borralho1,2, Mariana V. Machado3,4, Helena Cortez-Pinto3,4, Cecília M.P. Rodrigues1,2
1Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
2Department of Biochemistry and Human Biology, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
3Department of Gastroenterology, Hospital de Santa Maria, Lisbon, Portugal
4Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

Tài liệu tham khảo

Cheung, 2009, Recent advances in nonalcoholic fatty liver disease, Curr Opin Gastroenterol, 25, 230, 10.1097/MOG.0b013e3283294a18 Canbay, 2004, Apoptosis: the nexus of liver injury and fibrosis, Hepatology, 39, 273, 10.1002/hep.20051 Ferreira, 2011, Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease, Diabetologia, 54, 1788, 10.1007/s00125-011-2130-8 Sayed, 2011, MicroRNAs in development and disease, Physiol Rev, 91, 827, 10.1152/physrev.00006.2010 Cheung, 2008, Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression, Hepatology, 48, 1810, 10.1002/hep.22569 Li, 2009, Differential expression of microRNAs in mouse liver under aberrant energy metabolic status, J Lipid Res, 50, 1756, 10.1194/jlr.M800509-JLR200 Pogribny, 2010, Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice, Lab Invest, 90, 1437, 10.1038/labinvest.2010.113 Hermeking, 2010, The miR-34 family in cancer and apoptosis, Cell Death Differ, 17, 193, 10.1038/cdd.2009.56 Yamakuchi, 2008, MiR-34a repression of SIRT1 regulates apoptosis, Proc Natl Acad Sci USA, 105, 13421, 10.1073/pnas.0801613105 Chang, 2007, Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis, Mol Cell, 26, 745, 10.1016/j.molcel.2007.05.010 Panasiuk, 2006, Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease, World J Gastroenterol, 12, 6198, 10.3748/wjg.v12.i38.6198 Farrell, 2009, Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression, J Gastroenterol Hepatol, 24, 443, 10.1111/j.1440-1746.2009.05785.x Rodrigues, 1998, A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation, J Clin Invest, 101, 2790, 10.1172/JCI1325 Amaral, 2007, P53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis, J Biol Chem, 282, 34250, 10.1074/jbc.M704075200 Castro, 2005, A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid, J Hepatol, 42, 897, 10.1016/j.jhep.2005.01.026 Sola, 2003, Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes, J Biol Chem, 278, 48831, 10.1074/jbc.M300468200 Castro, 2010, Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid, Am J Physiol Gastrointest Liver Physiol, 299, G887, 10.1152/ajpgi.00216.2010 Alisi, 2011, Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease, Lab Invest, 91, 283, 10.1038/labinvest.2010.166 Murakami, 2006, Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues, Oncogene, 25, 2537, 10.1038/sj.onc.1209283 Colak, 2011, SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease, Med Sci Monit, 17, 10.12659/MSM.881749 Audrito, 2011, Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network, Cancer Res, 71, 4473, 10.1158/0008-5472.CAN-10-4452 Chen, 2011, Mir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation, PLoS One, 6, e20238, 10.1371/journal.pone.0020238 Gao, 2011, Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity, J Biol Chem, 286, 22227, 10.1074/jbc.M111.228874 Castro, 2007, Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes, Am J Physiol Gastrointest Liver Physiol, 293, G327, 10.1152/ajpgi.00093.2007 Jin, 2011, Transition from hepatic steatosis to steatohepatitis: unique microRNA patterns and potential downstream functions and pathways, J Gastroenterol Hepatol Cermelli, 2011, Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease, PLoS One, 6, e23937, 10.1371/journal.pone.0023937 Li, 2011, Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1, Mech Ageing Dev, 132, 75, 10.1016/j.mad.2010.12.004 Min, 2012, Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease, Cell Metab, 15, 665, 10.1016/j.cmet.2012.04.004 Benz, 2000, Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes, Eur J Clin Invest, 30, 203, 10.1046/j.1365-2362.2000.00615.x Malhi, 2008, Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease, Semin Liver Dis, 28, 360, 10.1055/s-0028-1091980 Xu, 2010, Lack of SIRT1 (mammalian sirtuin 1) activity leads to liver steatosis in the SIRT1+/− mice: a role of lipid mobilization and inflammation, Endocrinology, 151, 2504, 10.1210/en.2009-1013 Purushotham, 2009, Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation, Cell Metab, 9, 327, 10.1016/j.cmet.2009.02.006 Brooks, 2011, The impact of acetylation and deacetylation on the p53 pathway, Protein Cell, 2, 456, 10.1007/s13238-011-1063-9 Amaral, 2010, Ursodeoxycholic acid modulates the ubiquitin–proteasome degradation pathway of p53, Biochem Biophys Res Commun, 400, 649, 10.1016/j.bbrc.2010.08.121 Lindor, 2004, Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial, Hepatology, 39, 770, 10.1002/hep.20092 Ratziu, 2011, A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis, J Hepatol, 54, 1011, 10.1016/j.jhep.2010.08.030 Tsuchida, 2011, Ursodeoxycholic acid improves insulin sensitivity and hepatic steatosis by inducing the excretion of hepatic lipids in high-fat diet-fed KK-A(y) mice, Metabolism Buko, 2011, Ursodeoxycholic acid dose-dependently improves liver injury in rats fed a methionine- and choline-deficient diet, Hepatol Res, 41, 647, 10.1111/j.1872-034X.2011.00820.x