Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes
Tài liệu tham khảo
Kaplowitz, 2001, Drug-induced liver disorders: implications for drug development and regulation, Drug Saf., 24, 483, 10.2165/00002018-200124070-00001
Schuster, 2005, Why drugs fail – A study on side effects in new chemical entities, Curr. Pharm. Des, 11, 3545, 10.2174/138161205774414510
Stieger, 2000, Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver, Gastroenterology, 118, 422, 10.1016/S0016-5085(00)70224-1
Fattinger, 2001, The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions, Clin. Pharmacol. Ther., 69, 223, 10.1067/mcp.2001.114667
Byrne, 2002, The human bile salt export pump: characterization of substrate specificity and identification of inhibitors, Gastroenterology, 123, 1649, 10.1053/gast.2002.36591
Kostrubsky, 2006, Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone, Toxicol. Sci., 90, 451, 10.1093/toxsci/kfj095
Morgan, 2010, Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development, Toxicol. Sci., 118, 485, 10.1093/toxsci/kfq269
Fickert, 2006, Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice, Am. J. Pathol., 168, 410, 10.2353/ajpath.2006.050404
Zucchini-Pascal, 2009, Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis, Liver Int., 30, 284, 10.1111/j.1478-3231.2009.02108.x
Spivey, 1993, Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium, J. Clin. Invest., 92, 17, 10.1172/JCI116546
Reinehr, 2003, Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation, Gastroenterology, 125, 839, 10.1016/S0016-5085(03)01055-2
Meier, 2002, Bile salt transporters, Annu. Rev. Physiol., 64, 635, 10.1146/annurev.physiol.64.082201.100300
Strautnieks, 1998, A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis, Nat. Genet., 20, 233, 10.1038/3034
Choi, 2003, Nefazodone (Serzone) withdrawn because of hepatotoxicity, Cmaj, 169, 1187
Gitlin, 1998, Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone, Ann. Int. Med., 129, 36, 10.7326/0003-4819-129-1-199807010-00008
Tang, 2007, Drug metabolite profiling and elucidation of drug-induced hepatotoxicity, Expert Opin. Drug Metab. Toxicol., 3, 407, 10.1517/17425255.3.3.407
Swift, 2010, Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity, Drug Metab. Rev., 42, 446, 10.3109/03602530903491881
Liu, 1999, Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats, Drug Metab. Dispos., 27, 637
Scherer, 2009, Rapid quantification of bile acids and their conjugates in serum by liquid chromatography–tandem mass spectrometry, J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 877, 3920, 10.1016/j.jchromb.2009.09.038
Iwanaga, 2007, Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis, Biol. Pharm. Bull., 30, 739, 10.1248/bpb.30.739
Stieger, 2010, Role of the bile salt export pump, BSEP, in acquired forms of cholestasis, Drug Metab. Rev., 42, 437, 10.3109/03602530903492004
Fujimoto, 2010, In vitro cytotoxicity assay to evaluate the toxicity of an electrophilic reactive metabolite using glutathione-depleted rat primary cultured hepatocytes, Chem. Biol. Interact., 188, 404, 10.1016/j.cbi.2010.09.012
Kemp, 2004, Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure, Toxicol. In Vitro, 18, 869, 10.1016/j.tiv.2004.04.014
Grub, 2000, Mechanisms of cyclosporine A-induced apoptosis in rat hepatocyte primary cultures, Toxicol. Appl. Pharmacol., 163, 209, 10.1006/taap.1999.8887
Ortiz de Montellano, 1981, Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzene-protoporphyrin IX adduct, Biochem. J., 195, 761, 10.1042/bj1950761
Nakanishi, 2011, Quantitative time-lapse imaging-based analysis of drug–drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes, Drug Metab. Dispos., 39, 984, 10.1124/dmd.111.038059
Alvaro, 1986, Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species, Comp. Biochem. Physiol. B., 83, 551, 10.1016/0305-0491(86)90295-6
Hayashi, 2005, Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep, Biochim. Biophys. Acta, 1738, 54, 10.1016/j.bbalip.2005.10.006
Schroeder, 1998, Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells, Am. J. Physiol., 274, G370
Marion, 2011, Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes, Toxicol. Sci., 120, 371, 10.1093/toxsci/kfr014
Kotani, 2011, Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes, Drug Metab. Dispos., 39, 1503, 10.1124/dmd.111.038968
Jemnitz, 2010, Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human, Toxicol. Sci., 115, 80, 10.1093/toxsci/kfq044
T. Yokoi, Troglitazone, Handb. Exp. Pharmacol. (2010) 419–435.