MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

Cell Metabolism - Tập 22 - Trang 590-605 - 2015
Patricia Sancho1,2, Emma Burgos-Ramos2, Alejandra Tavera2, Tony Bou Kheir1, Petra Jagust1, Matthieu Schoenhals1, David Barneda1, Katherine Sellers3, Ramon Campos-Olivas4, Osvaldo Graña5, Catarina R. Viera2, Mariia Yuneva3, Bruno Sainz2, Christopher Heeschen1,2
1Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK
2Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
3The Francis Crick Institute, Mill Hill Laboratories, The Ridgeway, London NW7 1AA, UK
4Spectroscopy and NMR Unit, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
5Bioinformatics Unit and Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain

Tài liệu tham khảo

Akita, 2014, MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism, Cancer Res., 74, 5903, 10.1158/0008-5472.CAN-14-0527

Hidalgo, 2010, Pancreatic cancer, N. Engl. J. Med., 362, 1605, 10.1056/NEJMra0901557

Rahib, 2014, Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States, Cancer Res., 74, 2913, 10.1158/0008-5472.CAN-14-0155