Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

Cell Stem Cell - Tập 9 Số 5 - Trang 433-446 - 2011
Enza Lonardo1, Patrick Hermann2, M Mueller3, Stephan Huber4, Anamaria Balic2, Irene Miranda‐Lorenzo2, Sladjana Zagorac2, Sonia Alcalá2, Iker Rodríguez-Arabaolaza2, Juan Carlos Ramírez5, Raúl Torres5, Elena García6, Manuel Hidalgo6, David Cebrián7, Rainer Heuchel8, Matthias Löhr8, Frank Berger9, Peter Bartenstein10, Alexandra Aicher2, Christopher Heeschen2
1Clinical Research Programme, Stem Cells and Cancer Group, Spanish National Cancer Research Centre, Madrid 28029, Spain.
2Clinical Research Programme, Stem Cells and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
3Department of Surgery, Ruprecht Karl University, Heidelberg 69120, Germany
4Department of Surgery, Ludwig-Maximilian-University, Munich 81377, Germany
5Viral Vector Unit, Spanish National Cardiovascular Research Centre (CNIC), Madrid, Spain
6Gastrointestinal Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
7Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
8Karolinska Institutet, Solna 171 65, Sweden
9Department of Radiology, Ludwig-Maximilian-University, Munich 81377, Germany
10Department of Nuclear Medicine, Ludwig-Maximilian-University, Munich 81377, Germany

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