Mitochondrial and energy metabolism‐related properties as novel indicators of lung cancer stem cells

International Journal of Cancer - Tập 129 Số 4 - Trang 820-831 - 2011
Xiaoqun Ye1, Qi Li1, Guanghui Wang1, Fenfen Sun1, Gui‐Xiang Huang1, Xiu‐Wu Bian2, Shi‐Cang Yu2,3, Guisheng Qian1
1Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China
2Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China
3Ward of Cadres, General Hospital of Chengdu Military Region, Chengdu, 610083, China

Tóm tắt

Abstract

Energy metabolism is the foundation of survival for all organisms, and mitochondria are the most important energy‐supplying organelles in eukaryotic cells. However, the mitochondrial and energy/metabolism‐related properties of cancer stem cells (CSCs), the stem cell‐like subpopulation in tumor masses, remain unknown. In our study, we compared the masses of mitochondria and mitochondrial DNA (mtDNA), the mitochondrial membrane potential (Δψm), oxygen/glucose consumption, and the concentration of reactive oxygen species (ROS) and ATP between lung CSCs (LCSCs) and non‐LCSCs. In addition, the change in features during differentiation was examined. Some mitochondrial and energy metabolism‐related properties, such as perinuclear mitochondrial distribution, a lower quantity of mtDNA, higher Δψm, lower oxygen/glucose consumption, and lower intracellular concentrations of ROS and ATP, can be used as indicators of LCSCs.

Từ khóa


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Thông tin
Thông tin xuất bản

International Journal of Cancer

Tập 129 Số 4

820-831

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