PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

Cancer Cell - Tập 23 Số 3 - Trang 287-301 - 2013
Francisca Vázquez1, Ji‐Hong Lim1, Helen Chim1, Kavita Bhalla2, Geoff Girnun2, Kerry A. Pierce3, Clary B. Clish3, Scott R. Granter4, Hans R. Widlund5, Bruce M. Spiegelman1, Pere Puigserver1
1Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
2Stewart Greenebaum Cancer Center, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
3Metabolite Profiling Initiative, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
4Department of Pathology, Harvard Skin Disease Research Center, Brigham and Women’s Hospital, Boston, MA 02115, USA
5Department of Dermatology/Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, MA 02115, USA

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