PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Tóm tắt
Từ khóa
Tài liệu tham khảo
Barretina, 2012, The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature, 483, 603, 10.1038/nature11003
Bertolotto, 2011, A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma, Nature, 480, 94, 10.1038/nature10539
Bogunovic, 2009, Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival, Proc. Natl. Acad. Sci. USA, 106, 20429, 10.1073/pnas.0905139106
Chang, 2011, The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer, Cancer Cell, 20, 500, 10.1016/j.ccr.2011.08.023
Choo, 2010, Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply, Mol. Cell, 38, 487, 10.1016/j.molcel.2010.05.007
Clark, 2000, Genomic analysis of metastasis reveals an essential role for RhoC, Nature, 406, 532, 10.1038/35020106
Cunningham, 2007, mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex, Nature, 450, 736, 10.1038/nature06322
Diehn, 2009, Association of reactive oxygen species levels and radioresistance in cancer stem cells, Nature, 458, 780, 10.1038/nature07733
Eichner, 2011, Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks, Mitochondrion, 11, 544, 10.1016/j.mito.2011.03.121
Fernandez-Marcos, 2011, Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis, Am. J. Clin. Nutr., 93, 884S, 10.3945/ajcn.110.001917
Gao, 2009, c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism, Nature, 458, 762, 10.1038/nature07823
Garraway, 2005, Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma, Nature, 436, 117, 10.1038/nature03664
Grabacka, 2008, PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91, Pigment Cell Melanoma Res., 21, 388, 10.1111/j.1755-148X.2008.00460.x
Handschin, 2007, Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals, J. Biol. Chem., 282, 30014, 10.1074/jbc.M704817200
Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131
Hoek, 2008, In vivo switching of human melanoma cells between proliferative and invasive states, Cancer Res., 68, 650, 10.1158/0008-5472.CAN-07-2491
Kelly, 2004, Transcriptional regulatory circuits controlling mitochondrial biogenesis and function, Genes Dev., 18, 357, 10.1101/gad.1177604
Knutti, 2001, PGC-1, a versatile coactivator, Trends Endocrinol. Metab., 12, 360, 10.1016/S1043-2760(01)00457-X
Lerin, 2006, GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha, Cell Metab., 3, 429, 10.1016/j.cmet.2006.04.013
Lin, 2002, Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres, Nature, 418, 797, 10.1038/nature00904
Lin, 2008, Modeling genomic diversity and tumor dependency in malignant melanoma, Cancer Res., 68, 664, 10.1158/0008-5472.CAN-07-2615
Moffat, 2006, A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen, Cell, 124, 1283, 10.1016/j.cell.2006.01.040
Mootha, 2003, PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, Nat. Genet., 34, 267, 10.1038/ng1180
Mootha, 2004, Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle, Proc. Natl. Acad. Sci. USA, 101, 6570, 10.1073/pnas.0401401101
Ohta, 2008, Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth, Cancer Res., 68, 1303, 10.1158/0008-5472.CAN-07-5003
Padmanabhan, 2006, Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer, Mol. Cell, 21, 689, 10.1016/j.molcel.2006.01.013
Puigserver, 2003, Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator, Endocr. Rev., 24, 78, 10.1210/er.2002-0012
Puigserver, 1998, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis, Cell, 92, 829, 10.1016/S0092-8674(00)81410-5
Raj, 2011, Selective killing of cancer cells by a small molecule targeting the stress response to ROS, Nature, 475, 231, 10.1038/nature10167
Rhee, 2003, Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis, Proc. Natl. Acad. Sci. USA, 100, 4012, 10.1073/pnas.0730870100
Riker, 2008, The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis, BMC Med. Genomics, 1, 13, 10.1186/1755-8794-1-13
Sahin, 2011, Telomere dysfunction induces metabolic and mitochondrial compromise, Nature, 470, 359, 10.1038/nature09787
Scarpulla, 2011, Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network, Biochim. Biophys. Acta, 1813, 1269, 10.1016/j.bbamcr.2010.09.019
Schreiber, 2004, The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis, Proc. Natl. Acad. Sci. USA, 101, 6472, 10.1073/pnas.0308686101
Sen, 2011, PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress, Mol. Cell, 44, 621, 10.1016/j.molcel.2011.08.044
Shibata, 2008, Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy, Proc. Natl. Acad. Sci. USA, 105, 13568, 10.1073/pnas.0806268105
Singh, 2006, Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer, PLoS Med., 3, e420, 10.1371/journal.pmed.0030420
St-Pierre, 2006, Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators, Cell, 127, 397, 10.1016/j.cell.2006.09.024
Strub, 2011, Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma, Oncogene, 30, 2319, 10.1038/onc.2010.612
Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. USA, 102, 15545, 10.1073/pnas.0506580102
Tait, 2010, Mitochondria and cell death: outer membrane permeabilization and beyond, Nature Rev. Mol. Cell Biol., 11, 621, 10.1038/nrm2952
Trachootham, 2006, Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate, Cancer Cell, 10, 241, 10.1016/j.ccr.2006.08.009
Trachootham, 2009, Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?, Nat. Rev. Drug Discov., 8, 579, 10.1038/nrd2803
Weinberg, 2009, Mitochondrial metabolism and cancer, Ann. N Y Acad. Sci., 1177, 66, 10.1111/j.1749-6632.2009.05039.x
Wende, 2005, PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism, Mol. Cell. Biol., 25, 10684, 10.1128/MCB.25.24.10684-10694.2005
Wise, 2008, Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction, Proc. Natl. Acad. Sci. USA, 105, 18782, 10.1073/pnas.0810199105
Yokoyama, 2011, A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma, Nature, 480, 99, 10.1038/nature10630