Roles of circRNAs in the tumour microenvironment

Molecular Cancer - Tập 19 - Trang 1-16 - 2020
Qiuge Zhang1,2, Weiwei Wang3, Quanbo Zhou4, Chen Chen4,2, Weitang Yuan4, Jinbo Liu4, Xiaoli Li1, Zhenqiang Sun4,2
1Department of Geriatric Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
3Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
4Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Tóm tắt

The tumour microenvironment (TME) constitutes the area surrounding the tumour during its development and has been demonstrated to play roles in cancer-related diseases through crosstalk with tumour cells. Circular RNAs (circRNAs) are a subpopulation of endogenous noncoding RNAs (ncRNAs) that are ubiquitously expressed in eukaryotes and have multiple biological functions in the regulation of cancer onset and progression. An increasing number of studies have shown that circRNAs participate in the multifaceted biological regulation of the TME. However, details on the mechanisms involved have remained elusive until now. In this review, we analyse the effects of circRNAs on the TME from various perspectives, including immune surveillance, angiogenesis, hypoxia, matrix remodelling, exo-circRNAs and chemoradiation resistance. Currently, the enormous potential for circRNA use in targeted therapy and as noninvasive biomarkers have drawn our attention. We emphasize the prospect of targeting circRNAs as an essential strategy to regulate TME, overcome cancer resistance and improve therapeutic outcomes.

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