Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals

Cancer Letters - Tập 394 - Trang 1-12 - 2017
Kefeng Wang1,2, Yin Sun2, Wei Tao2, Xiang Fei1, Chawnshang Chang2,3
1Department of Urology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
2George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology and The Wilmot cancer Center, University of Rochester Medical Center, Rochester, NY, 14642, USA
3Sex Hormone Research Center, China Medical University/Hospital, Taichung 404, Taiwan

Tài liệu tham khảo

Kashyap, 2005, Biochemical and molecular markers in renal cell carcinoma: an update and future prospects, Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 10, 258, 10.1080/13547500500218534 Lee, 2012, Gender-specific clinicopathological features and survival in patients with renal cell carcinoma (RCC), BJU Int., 110, E28, 10.1111/j.1464-410X.2011.10667.x Ha, 2015, Increased expression of androgen receptor mRNA in human renal cell carcinoma cells is associated with poor prognosis in patients with localized renal cell carcinoma, J. Urol., 194, 1441 Noh, 2013, Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients, Pathology, 45, 574, 10.1097/PAT.0b013e3283652c7a Qu, 2015, Circular RNA: a new star of noncoding RNAs, Cancer Lett., 365, 141, 10.1016/j.canlet.2015.06.003 Hansen, 2013, Natural RNA circles function as efficient microRNA sponges, Nature, 495, 384, 10.1038/nature11993 Hansen, 2013, Circular RNA and miR-7 in cancer, Cancer Res., 73, 5609, 10.1158/0008-5472.CAN-13-1568 Wotschofsky, 2012, Identification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas, Int. J. Biol. Sci., 8, 1363, 10.7150/ijbs.5106 Wang, 2016, ASC-J9((R)) suppresses castration resistant prostate cancer progression via degrading the enzalutamide-induced androgen receptor mutant AR-F876L, Cancer Lett., 379, 154, 10.1016/j.canlet.2016.05.018 Ma, 2014, Androgen receptor enhances cell adhesion and decreases cell migration via modulating beta1-integrin-AKT signaling in hepatocellular carcinoma cells, Cancer Lett., 351, 64, 10.1016/j.canlet.2014.05.017 He, 2014, ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen receptor-dependent HIF2alpha/VEGF signaling pathway, Cancer Res., 74, 4420, 10.1158/0008-5472.CAN-13-2681 Liu, 2010, Biochemical principles of small RNA pathways, Annu. Rev. Biochem., 79, 295, 10.1146/annurev.biochem.052208.151733 Vincent, 2009, Insights into how RNase R degrades structured RNA: analysis of the nuclease domain, J. Mol. Biol., 387, 570, 10.1016/j.jmb.2009.01.068 Wilusz, 2015, Repetitive elements regulate circular RNA biogenesis, Mob. Genet. Elem., 5, 1, 10.1080/2159256X.2015.1045682 You, 2015, Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity, Nat. Neurosci., 18, 603, 10.1038/nn.3975 Rybak-Wolf, 2015, Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed, Mol. Cell, 58, 870, 10.1016/j.molcel.2015.03.027 Lasda, 2014, Circular RNAs: diversity of form and function, RNA, 20, 1829, 10.1261/rna.047126.114 Jones, 2005, Gene signatures of progression and metastasis in renal cell cancer, Clin. Cancer Res.: an Official Journal of the American Association for Cancer Research., 11, 5730, 10.1158/1078-0432.CCR-04-2225 Sun, 2014, microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma, Int. J. Clin. Exp. Pathol., 7, 6871 Wang, 2013, MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42, Hepatology, 58, 642, 10.1002/hep.26373 Fu, 2013, Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42, FEBS Lett., 587, 3471, 10.1016/j.febslet.2013.08.036 Park, 2009, miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42, Nat. Struct. Mol. Biol., 16, 23, 10.1038/nsmb.1533 Oh, 2013, The type III TGFbeta receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells, Biochem. J., 454, 79, 10.1042/BJ20121701 Fantin, 2015, NRP1 regulates CDC42 activation to promote filopodia formation in endothelial tip cells, Cell Rep., 11, 1577, 10.1016/j.celrep.2015.05.018 Ruiz-Lafuente, 2015, Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells, Biol. Open, 4, 627, 10.1242/bio.20149050 Nobes, 1995, Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, 81, 53, 10.1016/0092-8674(95)90370-4 Luo, 2015, Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2alpha/androgen receptor signals, Oncotarget, 6, 27555, 10.18632/oncotarget.4515 Lin, 2015, Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals, Oncotarget, 6, 43081, 10.18632/oncotarget.5638 Barton, 2015, Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo, Mol. Cancer Ther., 14, 769, 10.1158/1535-7163.MCT-14-0926 Tian, 2015, Androgen receptor in hepatocarcinogenesis: recent developments and perspectives, Oncol. Lett., 9, 1983, 10.3892/ol.2015.3025 Scher, 2005, Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis, J. Clin. Oncol.: Official Journal of the American Society of Clinical Oncology, 23, 8253, 10.1200/JCO.2005.03.4777 Qin, 2014, Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer, J. Clin. Invest., 124, 5013, 10.1172/JCI76412 Chen, 2015, Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status, Oncotarget, 6, 31203, 10.18632/oncotarget.4522 Langner, 2004, Steroid hormone receptor expression in renal cell carcinoma: an immunohistochemical analysis of 182 tumors, J. Urol., 171, 611 Zhu, 2014, The expression and evaluation of androgen receptor in human renal cell carcinoma, Urology, 83, e19 Williams, 2015, Androgen receptor immunohistochemistry in genitourinary neoplasms, Int. Urol. Nephrol., 47, 81, 10.1007/s11255-014-0834-7 Brown, 1998, Hormone receptor immunoreactivity in hemangioblastomas and clear cell renal cell carcinomas, Mod. Pathol.: an Official Journal of the United States and Canadian Academy of Pathology, Inc., 11, 55 Zhao, 2016, A protective role for androgen receptor in clear cell renal cell carcinoma based on mining TCGA data, PloS One, 11, e0146505, 10.1371/journal.pone.0146505 Memczak, 2013, Circular RNAs are a large class of animal RNAs with regulatory potency, Nature, 495, 333, 10.1038/nature11928 Wang, 2016, A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223, Eur. Heart J., 10.1093/eurheartj/ehv713 Li, 2015, Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/beta-catenin pathway, Oncotarget, 6, 6001, 10.18632/oncotarget.3469 Stengel, 2011, Cdc42 in oncogenic transformation, invasion, and tumorigenesis, Cell. Signal., 23, 1415, 10.1016/j.cellsig.2011.04.001 Guo, 2015, R-Ketorolac targets Cdc42 and Rac1 and alters ovarian cancer cell behaviors critical for invasion and metastasis, Mol. Cancer Ther., 14, 2215, 10.1158/1535-7163.MCT-15-0419 Lin, 2014, Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells, Carcinogenesis, 35, 2425, 10.1093/carcin/bgu139 Ni, 2013, Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer, Cancer Sci., 104, 817, 10.1111/cas.12157