Circular RNA and miR-7 in Cancer

Cancer Research - Tập 73 Số 18 - Trang 5609-5612 - 2013
Thomas B. Hansen1, Jørgen Kjems1, Christian Kroun Damgaard1
1Authors' Affiliations: 1Department of Molecular Biology and Genetics; and 2Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark

Tóm tắt

Abstract MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often deregulated in cancer. The identification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA activity underscores the increasing complexity of ncRNA-mediated regulatory networks. Particularly, the recently identified circular RNA, ciRS-7, which acts as a designated miR-7 inhibitor/sponge, has conceptually changed the mechanistic understanding of miRNA networks. As miR-7 modulates the expression of several oncogenes, disclosing the regulation of miR-7 activity will likely advance the understanding of various cancer etiologies. Here, we review the current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways and discuss possible models explaining the relevance of coexpressing miR-7 along with a circRNA inhibitor. Cancer Res; 73(18); 5609–12. ©2013 AACR.

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Tài liệu tham khảo

Memczak, 2013, Circular RNAs are a large class of animal RNAs with regulatory potency, Nature, 495, 333, 10.1038/nature11928

Hansen, 2013, Natural RNA circles function as efficient microRNA sponges, Nature, 495, 384, 10.1038/nature11993

Salmena, 2011, A ceRNA hypothesis: the rosetta stone of a hidden RNA language?, Cell, 146, 353, 10.1016/j.cell.2011.07.014

Dropcho, 1987, Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration, Proc Natl Acad Sci U S A, 84, 4552, 10.1073/pnas.84.13.4552

Furneaux, 1989, Characterization of a cDNA encoding a 34-kDa purkinje neuron protein recognized by sera from patients with paraneoplastic cerebellar degeneration, Proc Natl Acad Sci U S A, 86, 2873, 10.1073/pnas.86.8.2873

Chen, 1990, Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse, Proc Natl Acad Sci U S A, 87, 3077, 10.1073/pnas.87.8.3077

Hansen, 2011, miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA, EMBO J, 30, 4414, 10.1038/emboj.2011.359

Satoh, 2004, Gene expression profile following stable expression of the cellular prion protein, Cell Mol Neurobiol, 24, 793, 10.1007/s10571-004-6920-0

Junn, 2009, Repression of alpha-synuclein expression and toxicity by microRNA-7, Proc Natl Acad Sci U S A, 106, 13052, 10.1073/pnas.0906277106

Wang, 2013, MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic beta-cells, Diabetes, 62, 887, 10.2337/db12-0451

Kefas, 2008, microRNA-7 inhibits the epidermal growth factor receptor and the akt pathway and is down-regulated in glioblastoma, Cancer Res, 68, 3566, 10.1158/0008-5472.CAN-07-6639

Reddy, 2008, MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions, Cancer Res, 68, 8195, 10.1158/0008-5472.CAN-08-2103

Webster, 2009, Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7, J Biol Chem, 284, 5731, 10.1074/jbc.M804280200

Saydam, 2011, miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways, Cancer Res, 71, 852, 10.1158/0008-5472.CAN-10-1219

Fang, 2012, miR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma, Hepatology, 55, 1852, 10.1002/hep.25576

Okuda, 2013, miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4, Cancer Res, 73, 1434, 10.1158/0008-5472.CAN-12-2037

Baccelli, 2012, The evolving concept of cancer and metastasis stem cells, J Cell Biol, 198, 281, 10.1083/jcb.201202014

Zhao, 2013, MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor, Oncogene, 32, 1363, 10.1038/onc.2012.156

Jiang, 2010, MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells, Biochem J, 432, 199, 10.1042/BJ20100859

Kong, 2012, MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression, PLoS ONE, 7, e41523, 10.1371/journal.pone.0041523

Wu, 2011, MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression, Chin Med J, 124, 2616

Zhang, 2012 3, microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis, Oncogene

Chou, 2010, EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF, Cancer Res, 70, 8822, 10.1158/0008-5472.CAN-10-0638

Cheng, 2005, Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis, Nucleic Acids Res, 33, 1290, 10.1093/nar/gki200

Duex, 2011, Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7, J Biol Chem, 286, 25377, 10.1074/jbc.M111.222760

Choudhury, 2013, Tissue-specific control of brain-enriched miR-7 biogenesis, Genes Dev, 27, 24, 10.1101/gad.199190.112

Lebedeva, 2011, Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR, Mol Cell, 43, 340, 10.1016/j.molcel.2011.06.008

Chen, 2010, miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro, Biochem Biophys Res Commun, 394, 921, 10.1016/j.bbrc.2010.03.076

Wu, 2010, A splicing-independent function of SF2/ASF in microRNA processing, Mol Cell, 38, 67, 10.1016/j.molcel.2010.02.021

Li, 2009, A microRNA imparts robustness against environmental fluctuation during development, Cell, 137, 273, 10.1016/j.cell.2009.01.058

Ebert, 2012, Roles for microRNAs in conferring robustness to biological processes, Cell, 149, 515, 10.1016/j.cell.2012.04.005

Gantier, 2011, Analysis of microRNA turnover in mammalian cells following Dicer1 ablation, Nucleic Acids Res, 39, 5692, 10.1093/nar/gkr148

Chatterjee, 2011, Target-mediated protection of endogenous microRNAs in C. elegans, Dev Cell, 20, 388, 10.1016/j.devcel.2011.02.008

Hutvagner, 2002, A microRNA in a multiple-turnover RNAi enzyme complex, Science, 297, 2056, 10.1126/science.1073827