The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients Tập 5 Số 48 - 2020
Lakshmanane Premkumar, Bruno Segovia-Chumbez, Ramesh Jadi, David R. Martinez, Rajendra Raut, Alena J. Markmann, Caleb Cornaby, Luther A. Bartelt, Susan R. Weiss, Yara Park, Caitlin E. Edwards, Eric T. Weimer, Erin M. Scherer, Nadine Rouphael, Srilatha Edupuganti, Daniela Weiskopf, Longping V. Tse, Yixuan J. Hou, David M. Margolis, Alessandro Sette, Matthew H. Collins, John L. Schmitz, Ralph S. Baric, Aravinda M. de Silva
The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance.
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients Tập 5 Số 52 - 2020
Baweleta Isho, Kento T. Abe, Michelle Zuo, Alainna J Jamal, Bhavisha Rathod, Jenny H. Wang, Zhijie Li, Gary Chao, Olga L. Rojas, Yeo Myong Bang, Annie Pu, Natasha Christie-Holmes, Christian Gervais, Derek F. Ceccarelli, Payman Samavarchi‐Tehrani, Furkan Guvenc, Patrick Budylowski, Angel Li, Aimee Paterson, Feng Yun Yue, Lina M. Marin, Lauren Caldwell, Jeffrey L. Wrana, Karen Colwill, Frank Sicheri, Samira Mubareka, Scott D. Gray‐Owen, Steven J. Drews, Walter L. Siqueira, Miriam Barrios‐Rodiles, Mario Ostrowski, James M. Rini, Yves Durocher, Allison McGeer, Jennifer L. Gommerman, Anne‐Claude Gingras
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19.
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 Tập 5 Số 49 - 2020
Jeong Seok Lee, Seong-Wan Park, Hye Won Jeong, Jin Young Ahn, Seong Jin Choi, Hoyoung Lee, Baekgyu Choi, Su Kyung Nam, Moa Sa, Ji‐Soo Kwon, Su Jin Jeong, Heung Kyu Lee, Sung Ho Park, Su‐Hyung Park, Jun Yong Choi, Sung‐Han Kim, Inkyung Jung, Eui‐Cheol Shin
Single-cell RNA sequencing of blood immune cells reveals type I interferon–associated hyper-inflammation in severe COVID-19.
Comprehensive mapping of immune perturbations associated with severe COVID-19 Tập 5 Số 49 - 2020
Leticia Kuri-Cervantes, M. Betina Pampena, Wenzhao Meng, Aaron M. Rosenfeld, C.A.G. Ittner, Ariel R. Weisman, R.S. Agyekum, Divij Mathew, Amy E. Baxter, Laura A. Vella, Oliva Kuthuru, Sokratis A. Apostolidis, Luanne Bershaw, Jeanette Dougherty, Allison R. Greenplate, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sigrid Gouma, Madison E. Weirick, Claudia P. Arevalo, Marcus J. Bolton, Eileen C. Goodwin, Elizabeth M. Anderson, Scott E. Hensley, Tiffanie K. Jones, Nilam S. Mangalmurti, Eline T. Luning Prak, E. John Wherry, Nuala J. Meyer, Michael R. Betts
Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19.
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients Tập 5 Số 52 - 2020
Anita Iyer, Forrest K. Jones, Ariana Nodoushani, Meagan Kelly, Margaret Becker, Damien Slater, Rachel Mills, Erica Teng, Mohammad Kamruzzaman, Wilfredo F. García-Beltrán, Michael G. Astudillo, Diane Yang, Tyler E. Miller, Elizabeth Oliver, Stephanie Fischinger, Caroline Atyeo, A. John Iafrate, Stephen B. Calderwood, Stephen A. Lauer, Jingyou Yu, Zhenfeng Li, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, John A. Branda, Sarah E. Turbett, Regina C. LaRocque, Guillaume Mellon, Dan H. Barouch, Aaron G. Schmidt, Andrew S. Azman, Galit Alter, Edward T. Ryan, Jason B. Harris, Richelle C. Charles
IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps Tập 3 Số 26 - 2018
Gabriel Sollberger, Axel Choidas, Garth L. Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nußbaumer, Bert Klebl, Renate Krüger, Alf Herzig, Arturo Zychlinsky
By screening a library of compounds that block NETosis, we have identified a gasdermin D inhibitor.
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis Tập 3 Số 26 - 2018
Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George Dubyak, Tsan Sam Xiao, Xiaoxia Li, Derek W. Abbott
Necrosulfonamide inhibits pyroptosis through direct inhibition of gasdermin D.
Natural killer cell immunotypes related to COVID-19 disease severity Tập 5 Số 50 - 2020
Christopher Maucourant, Iva Filipovic, Andrea Ponzetta, Soo Aleman, Martin Cornillet, Laura M. Palma Medina, Benedikt Strunz, Antonio Lentini, Björn Reinius, Demi Brownlie, Angélica Cuapio, Eivind Heggernes Ask, Ryan M. Hull, Alvaro Haroun-Izquierdo, Marie Schaffer, Jonas Klingström, Elin Folkesson, Marcus Buggert, Johan K. Sandberg, Lars I. Eriksson, Olav Rooyackers, Hans‐Gustaf Ljunggren, Karl‐Johan Malmberg, Jakob Michaëlsson, Nicole Marquardt, Quirin Hammer, Kristoffer Strålin, Niklas K. Björkström
The NK cell activation landscape in acute SARS-CoV-2 infection is associated with COVID-19 disease severity.
