Science immunology
2470-9468
2470-9468
Mỹ
Cơ quản chủ quản: AMER ASSOC ADVANCEMENT SCIENCE , American Association for the Advancement of Science
Phân tích ảnh hưởng
Thông tin về tạp chí
Lĩnh vực:
Immunology and AllergyImmunology
Science Immunology will publish original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques. The editors encourage submission of original research findings from all areas within the broad field of immunology from all model organisms, including humans. Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency). The editors and an international advisory group of scientists will hold Science Immunology articles to the same high-quality standard that is the hallmark of the Science family of journals.
M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis
IL-4/CCL24–mediated interaction with eosinophils maintains dermis-resident macrophages as replicative niches for
Leishmania major
.
Tập 5 Số 46 - 2020
Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response <i>to Mycobacterium tuberculosis</i> in vivo Induction of an NRF2-dependent cell-protective signature impairs alveolar macrophages from controlling M.tb. infection in vivo.
Tập 4 Số 37 - 2019
Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria Bacterial antigen encounter in a preweaning interval is critical for developing antigen-specific tolerance to gut bacteria.
Tập 2 Số 18 - 2017
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on genetic sequence, is currently replacing BA.1 in several countries, but its antigenic characteristics have not yet been assessed. Here, we used antigenic cartography to quantify and visualize antigenic differences between early SARS-CoV-2 variants (614G, Alpha, Beta, Gamma, Zeta, Delta, and Mu) using hamster antisera obtained after primary infection. We first verified that the choice of the cell line for the neutralization assay did not affect the topology of the map substantially. Antigenic maps generated using pseudo-typed SARS-CoV-2 on the widely used VeroE6 cell line and the human airway cell line Calu-3 generated similar maps. Maps made using authentic SARS-CoV-2 on Calu-3 cells also closely resembled those generated with pseudo-typed viruses. The antigenic maps revealed a central cluster of SARS-CoV-2 variants, which grouped on the basis of mutual spike mutations. Whereas these early variants are antigenically similar, clustering relatively close to each other in antigenic space, Omicron BA.1 and BA.2 have evolved as two distinct antigenic outliers. Our data show that BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics. Thus, antigenic cartography could be used to assess antigenic properties of future SARS-CoV-2 variants of concern that emerge and to decide on the composition of novel spike-based (booster) vaccines.
Tập 7 Số 75 - 2022
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration BMP4 produced by endothelial cells promotes thymic regeneration after acute damage by activating FOXN1 and its downstream targets.
Tập 3 Số 19 - 2018
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19 Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.
Tập 5 Số 51 - 2020
Comprehensive mapping of immune perturbations associated with severe COVID-19 Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19.
Tập 5 Số 49 - 2020
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy Human uterine NK cells continuously differentiate in response to the monthly regeneration of the endometrium and during pregnancy.
Tập 6 Số 56 - 2021
Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells Cytotoxic T cells use actin-rich protrusions at the immunological synapse to enhance perforin-mediated target cell killing.
Tập 4 Số 33 - 2019
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.
Tập 5 Số 52 - 2020