Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

Science immunology - Tập 3 Số 26 - 2018
Gabriel Sollberger1, Axel Choidas2, Garth L. Burn1, Peter Habenberger2, Raffaella Di Lucrezia2, Susanne Kordes2, Sascha Menninger2, Jan Eickhoff2, Peter Nußbaumer2, Bert Klebl2, Renate Krüger3, Alf Herzig1, Arturo Zychlinsky1
1Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany
2Lead Discovery Center GmbH, Otto-Hahn-Str. 15, Dortmund, Germany.
3Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Department of Pediatric Pneumology, Immunology and Intensive Care, Berlin, Germany.

Tóm tắt

By screening a library of compounds that block NETosis, we have identified a gasdermin D inhibitor.

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Science immunology

Tập 3 Số 26

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