Science immunology
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ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathwaysZBP1 activates the NLRP3 inflammasome and programmed cell death.
Science immunology - Tập 1 Số 2 - 2016
Neutrophil extracellular traps drive inflammatory pathogenesis in malariaNETs contribute to malaria by promoting emergency granulopoiesis and endothelial binding of parasitized erythrocytes.
Science immunology - Tập 4 Số 40 - 2019
Gasdermin D plays a vital role in the generation of neutrophil extracellular trapsBy screening a library of compounds that block NETosis, we have identified a gasdermin D inhibitor.
Science immunology - Tập 3 Số 26 - 2018
Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmittersThe gallbladder stores bile between meals and empties into the duodenum upon demand and is thereby exposed to the intestinal microbiome. This exposure raises the need for antimicrobial factors, among them, mucins produced by cholangiocytes, the dominant epithelial cell type in the gallbladder. The role of the much less frequent biliary tuft cells is still unknown. We here show that propion... ... hiện toàn bộ
Science immunology - Tập 7 Số 69 - 2022
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia
The intestinal tract is a common site for various types of infections including viruses, bacteria, and helminths, each requiring specific modes of immune defense. The intestinal epithelium has a pivotal role in both immune initiation and effector stages, which are coordinated by lymphocyte cytokines such as IFNγ, IL-13, and IL-22. Here, we studied intestinal epithelial immune ... ... hiện toàn bộ
Science immunology - Tập 7 Số 71 - 2022
Ketogenic diet activates protective γδ T cell responses against influenza virus infectionKetogenic diet protects mice against influenza virus infection through γδ T cell expansion and metabolic adaptation.
Science immunology - Tập 4 Số 41 - 2019
M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis
IL-4/CCL24–mediated interaction with eosinophils maintains dermis-resident macrophages as replicative niches for
Leishmania major
.
Science immunology - Tập 5 Số 46 - 2020
Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivoInduction of an NRF2-dependent cell-protective signature impairs alveolar macrophages from controlling M.tb. infection in vivo.
Science immunology - Tập 4 Số 37 - 2019
Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteriaBacterial antigen encounter in a preweaning interval is critical for developing antigen-specific tolerance to gut bacteria.
Science immunology - Tập 2 Số 18 - 2017
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinctThe emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on genetic sequence, is currently replacing BA.1 in several countries, but its antigenic characteristics have not yet been assessed. Here, we used antigenic cartography to quantify and visualize antigenic differences b... ... hiện toàn bộ
Science immunology - Tập 7 Số 75 - 2022
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