Science immunology

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Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
Science immunology - Tập 4 Số 40 - 2019
Sebastian Lorenz Knackstedt, Athina Georgiadou, Falko Apel, Ulrike Abu-Abed, Christopher A. Moxon, Aubrey J. Cunnington, Bärbel Raupach, Deirdre Cunningham, Jean Langhorne, Renate Krüger, Valentina Barrera, Simon Harding, Åse Berg, Sam Patel, Kari Otterdal, Benjamin Mordmüller, Evelin Schwarzer, Volker Brinkmann, Arturo Zychlinsky, Borko Amulic
NETs contribute to malaria by promoting emergency granulopoiesis and endothelial binding of parasitized erythrocytes.
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
Science immunology - Tập 3 Số 26 - 2018
Gabriel Sollberger, Axel Choidas, Garth L. Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nußbaumer, Bert Klebl, Renate Krüger, Alf Herzig, Arturo Zychlinsky
By screening a library of compounds that block NETosis, we have identified a gasdermin D inhibitor.
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Science immunology - Tập 5 Số 51 - 2020
Elizabeth R. Mann, Madhvi Menon, Sean Knight, Joanne E. Konkel, Christopher Brightling, Tovah N. Shaw, Siddharth Krishnan, Magnus Rattray, Andrew Ustianowski, Syed Murtuza Baker, Paul Dark, Graham M. Lord, Angela Simpson, Tim Felton, Ling‐Pei Ho, Marc Feldmann, John R. Grainger, Tracy Hussell
Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.
Comprehensive mapping of immune perturbations associated with severe COVID-19
Science immunology - Tập 5 Số 49 - 2020
Leticia Kuri-Cervantes, M. Betina Pampena, Wenzhao Meng, Aaron M. Rosenfeld, C.A.G. Ittner, Ariel R. Weisman, R.S. Agyekum, Divij Mathew, Amy E. Baxter, Laura A. Vella, Oliva Kuthuru, Sokratis A. Apostolidis, Luanne Bershaw, Jeanette Dougherty, Allison R. Greenplate, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sigrid Gouma, Madison E. Weirick, Claudia P. Arevalo, Marcus J. Bolton, Eileen C. Goodwin, Elizabeth M. Anderson, Scott E. Hensley, Tiffanie K. Jones, Nilam S. Mangalmurti, Eline T. Luning Prak, E. John Wherry, Nuala J. Meyer, Michael R. Betts
Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19.
Ketogenic diet activates protective γδ T cell responses against influenza virus infection
Science immunology - Tập 4 Số 41 - 2019
Emily L. Goldberg, Ryan D. Molony, Eriko Kudo, Sviatoslav Sidorov, Yong Kong, Vishwa Deep Dixit, Akiko Iwasaki
Ketogenic diet protects mice against influenza virus infection through γδ T cell expansion and metabolic adaptation.
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients
Science immunology - Tập 5 Số 52 - 2020
Anita Iyer, Forrest K. Jones, Ariana Nodoushani, Meagan Kelly, Margaret Becker, Damien Slater, Rachel Mills, Erica Teng, Mohammad Kamruzzaman, Wilfredo F. García-Beltrán, Michael G. Astudillo, Diane Yang, Tyler E. Miller, Elizabeth Oliver, Stephanie Fischinger, Caroline Atyeo, A. John Iafrate, Stephen B. Calderwood, Stephen A. Lauer, Jingyou Yu, Zhenfeng Li, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, John A. Branda, Sarah E. Turbett, Regina C. LaRocque, Guillaume Mellon, Dan H. Barouch, Aaron G. Schmidt, Andrew S. Azman, Galit Alter, Edward T. Ryan, Jason B. Harris, Richelle C. Charles
IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
Science immunology - Tập 5 Số 52 - 2020
Baweleta Isho, Kento T. Abe, Michelle Zuo, Alainna J Jamal, Bhavisha Rathod, Jenny H. Wang, Zhijie Li, Gary Chao, Olga L. Rojas, Yeo Myong Bang, Annie Pu, Natasha Christie-Holmes, Christian Gervais, Derek F. Ceccarelli, Payman Samavarchi‐Tehrani, Furkan Guvenc, Patrick Budylowski, Angel Li, Aimee Paterson, Feng Yun Yue, Lina M. Marin, Lauren Caldwell, Jeffrey L. Wrana, Karen Colwill, Frank Sicheri, Samira Mubareka, Scott D. Gray‐Owen, Steven J. Drews, Walter L. Siqueira, Miriam Barrios‐Rodiles, Mario Ostrowski, James M. Rini, Yves Durocher, Allison McGeer, Jennifer L. Gommerman, Anne‐Claude Gingras
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19.
The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients
Science immunology - Tập 5 Số 48 - 2020
Lakshmanane Premkumar, Bruno Segovia-Chumbez, Ramesh Jadi, David R. Martinez, Rajendra Raut, Alena J. Markmann, Caleb Cornaby, Luther A. Bartelt, Susan R. Weiss, Yara Park, Caitlin E. Edwards, Eric T. Weimer, Erin M. Scherer, Nadine Rouphael, Srilatha Edupuganti, Daniela Weiskopf, Longping V. Tse, Yixuan J. Hou, David M. Margolis, Alessandro Sette, Matthew H. Collins, John L. Schmitz, Ralph S. Baric, Aravinda M. de Silva
The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance.
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants
Science immunology - Tập 7 Số 68 - 2022
Timothy A. Bates, Savannah K. McBride, Hans C. Leier, Gaelen Guzman, Zoë L. Lyski, Devin Schoen, Bradie Winders, Joon‐Yong Lee, David Xthona Lee, William B. Messer, Marcel E. Curlin, Fikadu Tafesse
Current coronavirus disease 2019 (COVID-19) vaccines effectively reduce overall morbidity and mortality and are vitally important to controlling the pandemic. Individuals who previously recovered from COVID-19 have enhanced immune responses after vaccination (hybrid immunity) compared with their naïve-vaccinated peers; however, the effects of post-vaccination breakthrough infections on hum...... hiện toàn bộ
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct
Science immunology - Tập 7 Số 75 - 2022
Anna Z. Mykytyn, Melanie Rissmann, Adinda Kok, Miruna E. Rosu, Debby Schipper, Tim I. Breugem, Petra B. van den Doel, Felicity Chandler, Theo M. Bestebroer, Maurice de Wit, Martin E. van Royen, Richard Molenkamp, Bas B. Oude Munnink, Rory D. de Vries, Corine H. GeurtsvanKessel, Derek J. Smith, Marion Koopmans, Barry Rockx, Mart M. Lamers, Ron A. M. Fouchier, Bart L. Haagmans
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on genetic sequence, is currently replacing BA.1 in several countries, but its antigenic characteristics have not yet been assessed. Here, we used antigenic cartography to quantify and visualize antigenic differences b...... hiện toàn bộ
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