Science immunology

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M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis
Science immunology - Tập 5 Số 46 - 2020
Sang Hun Lee, Mariana M. Chaves, Olena Kamenyeva, Pedro Henrique Gazzinelli-Guimarães, Byunghyun Kang, Gabriela Pessenda, Katiuska Passelli, Fabienne Tacchini‐Cottier, Juraj Kabát, Elizabeth A. Jacobsen, Thomas B. Nutman, David L. Sacks
IL-4/CCL24–mediated interaction with eosinophils maintains dermis-resident macrophages as replicative niches for Leishmania major .
Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response <i>to Mycobacterium tuberculosis</i> in vivo
Science immunology - Tập 4 Số 37 - 2019
Alissa C. Rothchild, Gregory S. Olson, Johannes Nemeth, Lynn M. Amon, Dat Mai, Elizabeth S. Gold, Alan H. Diercks, Alan Aderem
Induction of an NRF2-dependent cell-protective signature impairs alveolar macrophages from controlling M.tb. infection in vivo.
Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria
Science immunology - Tập 2 Số 18 - 2017
Kathryn A. Knoop, Jenny Gustafsson, Keely G. McDonald, Devesha H. Kulkarni, Paige E. Coughlin, Stephanie McCrate, Dongyeon Kim, Chyi‐Song Hsieh, Simon P. Hogan, Charles O. Elson, Phillip I. Tarr, Rodney D. Newberry
Bacterial antigen encounter in a preweaning interval is critical for developing antigen-specific tolerance to gut bacteria.
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct
Science immunology - Tập 7 Số 75 - 2022
Anna Z. Mykytyn, Melanie Rissmann, Adinda Kok, Miruna E. Rosu, Debby Schipper, Tim I. Breugem, Petra B. van den Doel, Felicity Chandler, Theo M. Bestebroer, Maurice de Wit, Martin E. van Royen, Richard Molenkamp, Bas B. Oude Munnink, Rory D. de Vries, Corine H. GeurtsvanKessel, Derek J. Smith, Marion Koopmans, Barry Rockx, Mart M. Lamers, Ron A. M. Fouchier, Bart L. Haagmans
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on genetic sequence, is currently replacing BA.1 in several countries, but its antigenic characteristics have not yet been assessed. Here, we used antigenic cartography to quantify and visualize antigenic differences between early SARS-CoV-2 variants (614G, Alpha, Beta, Gamma, Zeta, Delta, and Mu) using hamster antisera obtained after primary infection. We first verified that the choice of the cell line for the neutralization assay did not affect the topology of the map substantially. Antigenic maps generated using pseudo-typed SARS-CoV-2 on the widely used VeroE6 cell line and the human airway cell line Calu-3 generated similar maps. Maps made using authentic SARS-CoV-2 on Calu-3 cells also closely resembled those generated with pseudo-typed viruses. The antigenic maps revealed a central cluster of SARS-CoV-2 variants, which grouped on the basis of mutual spike mutations. Whereas these early variants are antigenically similar, clustering relatively close to each other in antigenic space, Omicron BA.1 and BA.2 have evolved as two distinct antigenic outliers. Our data show that BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics. Thus, antigenic cartography could be used to assess antigenic properties of future SARS-CoV-2 variants of concern that emerge and to decide on the composition of novel spike-based (booster) vaccines.
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration
Science immunology - Tập 3 Số 19 - 2018
Tobias Wertheimer, Enrico Velardi, Jennifer J. Tsai, Kenneth W. Cooper, Shiyun Xiao, Christopher C. Kloss, Katja J. Jarick, Zeinab Mokhtari, Christian Brede, Paul deRoos, Sinéad Kinsella, Brisa Palikuqi, Michael Ginsberg, Lauren Young, Fabiana M. Kreines, Sophie Lieberman, Amina Lazrak, Peipei Guo, Florent Malard, Odette M. Smith, Yusuke Shono, Robert R. Jenq, Alan M. Hanash, Daniel J. Nolan, Jason M. Butler, Andreas Beilhack, Nancy R. Manley, Shahin Rafii, Jarrod A. Dudakov, Marcel R.M. van den Brink
BMP4 produced by endothelial cells promotes thymic regeneration after acute damage by activating FOXN1 and its downstream targets.
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Science immunology - Tập 5 Số 51 - 2020
Elizabeth R. Mann, Madhvi Menon, Sean Knight, Joanne E. Konkel, Christopher Brightling, Tovah N. Shaw, Siddharth Krishnan, Magnus Rattray, Andrew Ustianowski, Syed Murtuza Baker, Paul Dark, Graham M. Lord, Angela Simpson, Tim Felton, Ling‐Pei Ho, Marc Feldmann, John R. Grainger, Tracy Hussell
Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.
Comprehensive mapping of immune perturbations associated with severe COVID-19
Science immunology - Tập 5 Số 49 - 2020
Leticia Kuri-Cervantes, M. Betina Pampena, Wenzhao Meng, Aaron M. Rosenfeld, C.A.G. Ittner, Ariel R. Weisman, R.S. Agyekum, Divij Mathew, Amy E. Baxter, Laura A. Vella, Oliva Kuthuru, Sokratis A. Apostolidis, Luanne Bershaw, Jeanette Dougherty, Allison R. Greenplate, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sigrid Gouma, Madison E. Weirick, Claudia P. Arevalo, Marcus J. Bolton, Eileen C. Goodwin, Elizabeth M. Anderson, Scott E. Hensley, Tiffanie K. Jones, Nilam S. Mangalmurti, Eline T. Luning Prak, E. John Wherry, Nuala J. Meyer, Michael R. Betts
Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19.
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy
Science immunology - Tập 6 Số 56 - 2021
Benedikt Strunz, Jonna Bister, Hanna Jönsson, Iva Filipovic, Ylva Crona Guterstam, Egle Kvedaraite, Natalie Sleiers, Bogdan Dumitrescu, Mats Brännström, Antonio Lentini, Björn Reinius, Martin Cornillet, Tim Willinger, Sebastian Gidlöf, Russell S. Hamilton, Martin A. Ivarsson, Niklas K. Björkström
Human uterine NK cells continuously differentiate in response to the monthly regeneration of the endometrium and during pregnancy.
Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells
Science immunology - Tập 4 Số 33 - 2019
Fella Tamzalit, Mitchell S. Wang, Weiyang Jin, María Tello‐Lafoz, Vitaly Boyko, John M. Heddleston, Charles T. Black, Lance C. Kam, Morgan Huse
Cytotoxic T cells use actin-rich protrusions at the immunological synapse to enhance perforin-mediated target cell killing.
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients
Science immunology - Tập 5 Số 52 - 2020
Anita Iyer, Forrest K. Jones, Ariana Nodoushani, Meagan Kelly, Margaret Becker, Damien Slater, Rachel Mills, Erica Teng, Mohammad Kamruzzaman, Wilfredo F. García-Beltrán, Michael G. Astudillo, Diane Yang, Tyler E. Miller, Elizabeth Oliver, Stephanie Fischinger, Caroline Atyeo, A. John Iafrate, Stephen B. Calderwood, Stephen A. Lauer, Jingyou Yu, Zhenfeng Li, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, John A. Branda, Sarah E. Turbett, Regina C. LaRocque, Guillaume Mellon, Dan H. Barouch, Aaron G. Schmidt, Andrew S. Azman, Galit Alter, Edward T. Ryan, Jason B. Harris, Richelle C. Charles
IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.
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