Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

Science immunology - Tập 5 Số 52 - 2020
Anita Iyer1,2, Forrest K. Jones3, Ariana Nodoushani2, Meagan Kelly2, Margaret Becker2, Damien Slater2, Rachel Mills2, Erica Teng2, Mohammad Kamruzzaman2, Wilfredo F. García-Beltrán4, Michael G. Astudillo4, Diane Yang4, Tyler E. Miller4, Elizabeth Oliver2, Stephanie Fischinger5, Caroline Atyeo5, A. John Iafrate4, Stephen B. Calderwood1,6,2, Stephen A. Lauer3, Jingyou Yu7, Zhenfeng Li7, Jared Feldman5, Blake M. Hauser5, Timothy M. Caradonna5, John A. Branda4, Sarah E. Turbett1,4,2, Regina C. LaRocque1,2, Guillaume Mellon2, Dan H. Barouch7,5, Aaron G. Schmidt6,5, Andrew S. Azman3, Galit Alter5, Edward T. Ryan8,1,2, Jason B. Harris9,2, Richelle C. Charles1,2
1Department of Medicine, Harvard Medical School, Boston, MA USA
2Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
4Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
5Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA
6Department of Microbiology, Harvard Medical School, Boston, MA, USA
7Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
8Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA
9Department of Pediatrics, Harvard Medical School, Boston, MA, USA;

Tóm tắt

IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.

Từ khóa


Tài liệu tham khảo

10.1056/NEJMp2002125

WHO Coronavirus Disease (COVID-19) Dashboard. https://covid19.who.int/. Accessed 28th September 2020.

10.1038/s41577-020-0359-5

10.1016/j.puhe.2020.04.009

10.1038/s41467-020-18450-4

10.1126/sciimmunol.abc8413

10.1093/cid/ciaa1247

10.1172/jci.insight.142386

10.1056/NEJMoa2026116

F. A. Ania Wajnberg Adolfo Firpo Deena Altman Mark Bailey Mayce Mansour Meagan McMahon Philip Meade Damodara Rao Mendu Kimberly Muellers Daniel Stadlbauer Kimberly Stone Shirin Strohmeier Judith Aberg David Reich Florian Krammer Carlos Cordon-Cardo SARS-CoV-2 infection induces robust neutralizing antibody responses that are stable for at least three months. medRxiv (2020) https://www.medrxiv.org/content/10.1101/2020.07.14.20151126v1

F. Javier Ibarrondo, A. Jennifer, Fulcher, David Goodman-Meza, Julie Elliott, Christian Hofmann, Mary A. Hausner, Kathie G. Ferbas, Nicole H. Tobin, Grace M. Aldrovandi, Otto O. Yang, Rapid Decay of Anti-SARS-CoV-2 Antibodies in Persons with Mild Covid-19. N. Engl. J. Med. (2020).

10.1038/s41591-020-0965-6

10.7326/M20-1495

10.1093/cid/ciaa310

10.1016/S1473-3099(20)30273-5

Antibody Test Seen as Key to Reopening Country Does Not Yet Deliver in The New York Times (Published April 19 2020).

Antibody tests for Covid-19 wrong up to half the time CDC in CNN . (May 26 2020).

Q. B. Zhen Zhang M Shisong Fang Lan Wei Xin Wang Jianfan He Yongsheng Wu BS1 Xiaojian Liu MMed Wei Gao MMed Renli Zhang Wenfeng Gong Qiru Su Andrew S Azman Justin Lessler Xuan Zou. (2020). Insights into the practical effectiveness of RT-PCR testing for SARS-CoV-2 from serologic data a cohort study (2020). Published online September 08 2020. https://doi.org/10.1101/2020.09.01.20182469

10.1016/j.diagmicrobio.2017.07.006

10.1126/science.abc4776

R. A. D. Elena Criscuolo Marta Strollo Serena Rolla Alessandro Ambrosi Massimo Locatelli Roberto Burioni Nicasio Mancini Massimo Clementi Nicola Clementi Poor correlation between antibody titers and neutralizing activity in sera from SARS-CoV-2 infected subjects. medRxiv (2020) https://www.medrxiv.org/content/10.1101/2020.07.10.20150375v1

Centers for Disease Control and Prevention Interim Guidelines for COVID-19 Antibody Testing at https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html. (2020). (2020). Accessed 27th July 2020. (2020).

M. Norman T. Gilboa A. F. Ogata A. M. Maley L. Cohen Y. Cai J. Zhang J. E. Feldman B. M. Hauser T. M. Caradonna B. Chen A. G. Schmidt G. Alter R. C. Charles E. T. Ryan D. R. Walt Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients. medRxiv (2020) https://www.medrxiv.org/content/10.1101/2020.04.28.20083691v1 Published online May 02 2020.

10.1038/s41467-020-16256-y

10.1126/science.abc6284

10.1126/sciimmunol.abc6347

C. Anderson-Bergman icenReg: Regression Models for Interval Censored Data in R. (2017). https://www.jstatsoft.org/article/view/v081i12

Thông tin
Thông tin xuất bản

Science immunology

Tập 5 Số 52

Thông tin tác giả