Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

Science immunology - Tập 5 Số 52 - 2020
Baweleta Isho1, Kento T. Abe2,3, Michelle Zuo1, Alainna J Jamal4,5, Bhavisha Rathod3, Jenny H. Wang3, Zhijie Li2, Gary Chao1, Olga L. Rojas1, Yeo Myong Bang1, Annie Pu1, Natasha Christie-Holmes6, Christian Gervais7, Derek F. Ceccarelli3, Payman Samavarchi‐Tehrani3, Furkan Guvenc2, Patrick Budylowski6,8, Angel Li4, Aimee Paterson4, Feng Yun Yue1, Lina M. Marin9, Lauren Caldwell3, Jeffrey L. Wrana2,3, Karen Colwill3, Frank Sicheri2,3, Samira Mubareka10,11,12,13, Scott D. Gray‐Owen6,2, Steven J. Drews14, Walter L. Siqueira9, Miriam Barrios‐Rodiles3, Mario Ostrowski1,15,16,17, James M. Rini18,2, Yves Durocher7, Allison McGeer4,5,3, Jennifer L. Gommerman1, Anne‐Claude Gingras2,3
1Department of Immunology, University of Toronto, Toronto, ON, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
3Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
4Department of Microbiology, at Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
5Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
6Combined Containment Level 3 Unit, University of Toronto,Toronto, ON, Canada
7Mammalian Cell Expression, Human Health Therapeutics Research Centre, National Research Council Canada, Montréal, QC, Canada.
8Institute of Medical Science, University of Toronto, Toronto, ON, Canada
9College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada
10Biological Sciences, Sunnybrook Research Institute
11Department of Laboratory Medicine and Molecular Diagnostics, Division of Microbiology, Sunnybrook Health Sciences Centre; Biological Sciences, Sunnybrook Research Institute; and Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada.
12Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada
13Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
14Canadian Blood Services, Edmonton, AB & Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
15Department of Medicine, University of Toronto, Toronto, ON, Canada
16Li Ka Shing Knowledge Institute
17St. Michael’s Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute.
18Department of Biochemistry, University of Toronto, Toronto, ON, Canada

Tóm tắt

Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19.

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Science immunology

Tập 5 Số 52

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