Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Science immunology - Tập 5 Số 51 - 2020
Elizabeth R. Mann1,2, Madhvi Menon1, Sean Knight1,3, Joanne E. Konkel1, Christopher Brightling1, Tovah N. Shaw1, Siddharth Krishnan1, Magnus Rattray4, Andrew Ustianowski5, Syed Murtuza Baker3, Paul Dark6,7, Graham M. Lord1, Angela Simpson6, Tim Felton6, Ling‐Pei Ho8, Marc Feldmann9, John R. Grainger1, Tracy Hussell1
1Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester M13 9PL, UK.
2Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 5th Floor St. Mary's Hospital, Oxford Road, Manchester M13 9WL, UK
3Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK
4Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
5Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK
6Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, UK
7Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
8MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
9Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford OX3 7LD, UK.

Tóm tắt

Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.

Từ khóa


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Science immunology

Tập 5 Số 51

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