Comprehensive mapping of immune perturbations associated with severe COVID-19

Science immunology - Tập 5 Số 49 - 2020
Leticia Kuri-Cervantes1,2, M. Betina Pampena1,2, Wenzhao Meng3, Aaron M. Rosenfeld3, C.A.G. Ittner4, Ariel R. Weisman4, R.S. Agyekum4, Divij Mathew1,5, Amy E. Baxter1,5, Laura A. Vella6,2, Oliva Kuthuru5,2, Sokratis A. Apostolidis5,7,2, Luanne Bershaw5,2, Jeanette Dougherty5,2, Allison R. Greenplate5,2, Ajinkya Pattekar8,2, Justin Kim5,2, Nicholas Han5,2, Sigrid Gouma1,2, Madison E. Weirick1,2, Claudia P. Arevalo1,2, Marcus J. Bolton1,2, Eileen C. Goodwin1,2, Elizabeth M. Anderson1,2, Scott E. Hensley1,2, Tiffanie K. Jones4, Nilam S. Mangalmurti4,2, Eline T. Luning Prak3, E. John Wherry5,2,9, Nuala J. Meyer4, Michael R. Betts1,2
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA.
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
6Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
7Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
8Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
9Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Tóm tắt

Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19.

Từ khóa


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Science immunology

Tập 5 Số 49

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