Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Science immunology - Tập 5 Số 49 - 2020
Jeong Seok Lee1, Seong-Wan Park2, Hye Won Jeong3, Jin Young Ahn4, Seong Jin Choi1, Hoyoung Lee1, Baekgyu Choi2, Su Kyung Nam2, Moa Sa1,5, Ji‐Soo Kwon6,1, Su Jin Jeong4, Heung Kyu Lee1,5, Sung Ho Park7, Su‐Hyung Park1,5, Jun Yong Choi4, Sung‐Han Kim6, Inkyung Jung2, Eui‐Cheol Shin1,5
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
2Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea
3Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea
4Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
5The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea
6Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
7School of Life Sciences, Ulsan National Institute of Science & Technology (UNIST), Ulsan 44919, Republic of Korea.

Tóm tắt

Single-cell RNA sequencing of blood immune cells reveals type I interferon–associated hyper-inflammation in severe COVID-19.

Từ khóa


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Science immunology

Tập 5 Số 49

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