Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

Science immunology - Tập 3 Số 26 - 2018
Joseph K. Rathkey1, Junjie Zhao2, Zhonghua Liu1, Yinghua Chen3, Jie Yang1,3, Hannah Kondolf1, Bryan L. Benson1, Steven M. Chirieleison1, Alex Y. Huang1,4, George Dubyak3, Tsan Sam Xiao1, Xiaoxia Li2, Derek W. Abbott1
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
4Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Tóm tắt

Necrosulfonamide inhibits pyroptosis through direct inhibition of gasdermin D.

Từ khóa


Tài liệu tham khảo

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Science immunology

Tập 3 Số 26

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