The application of retinal fundus camera imaging in dementia: A systematic review Tập 6 Số 1 - Trang 91-107 - 2017
Sarah McGrory, James R. Cameron, Enrico Pellegrini, Claire Warren, Fergus Doubal, Ian J. Deary, Baljean Dhillon, Joanna M. Wardlaw, Emanuele Trucco, Tom MacGillivray
AbstractIntroductionThe ease of imaging the retinal vasculature, and the evolving evidence suggesting this microvascular bed might reflect the cerebral microvasculature, presents an opportunity to investigate cerebrovascular disease and the contribution of microvascular disease to dementia with fundus camera imaging.... hiện toàn bộ Harmonization of neuroimaging biomarkers for neurodegenerative diseases: A survey in the imaging community of perceived barriers and suggested actions Tập 11 - Trang 69-73 - 2019
Jorge Jovicich, Frederik Barkhof, Claudio Babiloni, Karl Herholz, Christoph Mulert, Bart N.M. van Berckel, Giovanni B. Frisoni
AbstractIntroductionMolecular, functional, and structural neuroimaging biomarkers are largely used to study neurodegenerative diseases, but their benefits to patients/science might be greatly enhanced by improving standardization and cross‐validation. In this EU Joint Programme‐Neurodegenerative Diseases Research–funded project, w...... hiện toàn bộ Development and validation of a salivary tau biomarker in Alzheimer's disease Tập 11 - Trang 53-60 - 2018
Heather Pekeles, Hamid Y. Qureshi, Hemant K. Paudel, Hyman M. Schipper, Mervyn Gornistky, Howard Chertkow
AbstractIntroductionTotal tau (t‐tau) and phosphorylated tau (p‐tau) are abnormally elevated in the brain and cerebrospinal fluid of individuals with Alzheimer's disease (AD). Tau is also present in the salivary gland tissue and saliva, and salivary measures might produce an accurate, accessible, and inexpensive biomarker.... hiện toàn bộ Evaluating combinations of diagnostic tests to discriminate different dementia types Tập 10 - Trang 509-518 - 2018
Marie Bruun, Hanneke F.M. Rhodius-Meester, Juha Koikkalainen, Marta Baroni, Le Gjerum, Afina W. Lemstra, Frederik Barkhof, Anne M. Remes, Timo Urhemaa, Antti Tolonen, Daniel Rueckert, Mark van Gils, Kristian S. Frederiksen, Gunhild Waldemar, Philip Scheltens, Patrizia Mecocci, Hilkka Soininen, Jyrki Lötjönen, Steen G. Hasselbalch, Wiesje M. van der Flier
AbstractIntroductionWe studied, using a data‐driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia.MethodsIn this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal deme...... hiện toàn bộ Computer mouse movement patterns: A potential marker of mild cognitive impairment Tập 1 - Trang 472-480 - 2015
Adriana Seelye, Stuart Hagler, Nora Mattek, Diane B. Howieson, Katherine Wild, Hiroko H. Dodge, Jeffrey A. Kaye
AbstractIntroductionSubtle changes in cognitively demanding activities occur in mild cognitive impairment (MCI) but are difficult to assess with conventional methods. In an exploratory study, we examined whether patterns of computer mouse movements obtained from routine home computer use discriminated between older adults with and...... hiện toàn bộ Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood‐based biomarkers Tập 3 - Trang 51-62 - 2016
Cassandra A. DeMarshall, Eric P. Nagele, Abhirup Sarkar, Nimish K. Acharya, George Godsey, Eric L. Goldwaser, Mary Kosciuk, Umashanger Thayasivam, Min Han, Benjamin Belinka, Robert G. Nagele
AbstractIntroductionThere is an urgent need to identify biomarkers that can accurately detect and diagnose Alzheimer's disease (AD). Autoantibodies are abundant and ubiquitous in human sera and have been previously demonstrated as disease‐specific biomarkers capable of accurately diagnosing mild‐moderate stages of AD and Parkinson...... hiện toàn bộ