The application of retinal fundus camera imaging in dementia: A systematic review

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 6 Số 1 - Trang 91-107 - 2017
Sarah McGrory1, James R. Cameron2,1, Enrico Pellegrini1, Claire Warren3, Fergus Doubal1, Ian J. Deary4,5, Baljean Dhillon1, Joanna M. Wardlaw1,4,6, Emanuele Trucco7, Tom MacGillivray1,8
1Centre for Clinical Brain Sciences College of Medicine and Veterinary Medicine, University of Edinburgh Edinburgh UK
2Anne Rowling Regenerative Neurology Clinic College of Medicine and Veterinary Medicine, University of Edinburgh Edinburgh UK
3College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
4Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
5Department of Psychology, Centre for Cognitive Ageing and Cognitive EpidemiologyUniversity of EdinburghEdinburghUK
6Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK
7VAMPIRE Project and Computer Vision and Image Processing Group School of Science and Engineering (Computing), University of Dundee Dundee UK
8VAMPIRE Project and Edinburgh Clinical Research Facility University of Edinburgh Edinburgh UK

Tóm tắt

AbstractIntroductionThe ease of imaging the retinal vasculature, and the evolving evidence suggesting this microvascular bed might reflect the cerebral microvasculature, presents an opportunity to investigate cerebrovascular disease and the contribution of microvascular disease to dementia with fundus camera imaging.MethodsA systematic review and meta‐analysis was carried out to assess the measurement of retinal properties in dementia using fundus imaging.ResultsTen studies assessing retinal properties in dementia were included. Quantitative measurement revealed significant yet inconsistent pathologic changes in vessel caliber, tortuosity, and fractal dimension. Retinopathy was more prevalent in dementia. No association of age‐related macular degeneration with dementia was reported.DiscussionInconsistent findings across studies provide tentative support for the application of fundus camera imaging as a means of identifying changes associated with dementia. The potential of fundus image analysis in differentiating between dementia subtypes should be investigated using larger well‐characterized samples. Future work should focus on refining and standardizing methods and measurements.

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Tập 6 Số 1

91-107

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