Harmonization of neuroimaging biomarkers for neurodegenerative diseases: A survey in the imaging community of perceived barriers and suggested actions

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 11 - Trang 69-73 - 2019
Jorge Jovicich1, Frederik Barkhof2,3, Claudio Babiloni4,5, Karl Herholz6, Christoph Mulert7, Bart N.M. van Berckel8, Giovanni B. Frisoni9,10
1Center for Mind/Brain Sciences, University of Trento, Trento, Italy
2Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands
3Insititutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom
4Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Rome, Italy
5Department of Neuroscience, IRCCS-Hospital San Raffaele Pisana of Rome and Cassino, Rome and Cassino, Italy
6Division of Neuroscience & Experimental Psychology, University of Manchester, Manchester, United Kingdom
7Department of Psychiatry and Psychotherapy, University Medical Center Hamburg. Eppendorf, Hamburg, Germany
8Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
9Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Fatebenefratelli, Brescia, Italy
10Memory Clinic and LANVIE – Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland

Tóm tắt

AbstractIntroductionMolecular, functional, and structural neuroimaging biomarkers are largely used to study neurodegenerative diseases, but their benefits to patients/science might be greatly enhanced by improving standardization and cross‐validation. In this EU Joint Programme‐Neurodegenerative Diseases Research–funded project, we surveyed the neuroimaging community to assess perceived barriers in multicentric neuroimaging harmonization and actions to overcome them.MethodsAn anonymous survey addressed researchers, clinicians, pharma industry, and professional associations, inquiring about both general and modality‐specific harmonization barriers.ResultsSurvey participants (459) represented an international (37 countries) multidisciplinary community. We identified two sets of funding actions, one proposing the creation of an updated hub of documents to help researchers plan and execute multicentric neuroimaging studies capitalizing from previous studies, and the other focused on modality‐specific harmonization challenges in future neurodegenerative diseases clinical trials.DiscussionThis large survey of priorities and actions may help define harmonization calls launched by worldwide science funding agencies.

Tài liệu tham khảo

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Tập 11

69-73

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